Dextromethorphan

20 interactions 4 explained in plain English
Also sold as: Delsym
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Hydromorphone Rectal Amitriptyline Fentanyl Transdermal Patch Buprenorphine Memantine
1 Contraindicated 18 Major 1 Moderate
All (20) Contraindicated (1) Major (18) Moderate (1)

Contraindicated

Dextromethorphan Linezolid Injection Zyvox An increased risk of serotonin syndrome Details

Major

Dextromethorphan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Dextromethorphan Amitriptyline Elavil Explained Increased risk of serotonin syndrome Details Dextromethorphan Sertraline Explained Increased dextromethorphan exposure and an increased risk of serotonin syndrome Details Dextromethorphan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Dextromethorphan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Dextromethorphan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Dextromethorphan Dolasetron Anzemet Increased risk of serotonin syndrome Details Dextromethorphan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Dextromethorphan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Dextromethorphan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Dextromethorphan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Dextromethorphan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Dextromethorphan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Dextromethorphan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Dextromethorphan Memantine Namenda Increased adverse events of N-methyl-D-aspartate antagonists Details Dextromethorphan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Dextromethorphan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Dextromethorphan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Dextromethorphan Abiraterone Abirtega Increased dextromethorphan exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.