Medication interaction hub

What Supplements Interact with Aspirin, Caffeine?

Aspirin, Caffeine brand name: Anacin. Every interaction below applies to the brands too.

347 Interactions 13 Major 285 Moderate 49 Minor
Curated & coded by · Clinical Pharmacist · Updated October 8, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Caffeine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Caffeine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anacin combines aspirin with caffeine, so supplements can hit it from two directions, and a few of the 347 on this list deserve real respect. The biggest group, over 200 ingredients, can raise bleeding risk on top of aspirin's blood-thinning effect; beer and wine carry major ratings because alcohol plus an aspirin-type drug makes stomach bleeding more likely. Another 44, ephedra among them, stack extra stimulation onto the caffeine and can push heart rate and blood pressure up.

Thirteen entries rate major, and those are worth understanding first; the 285 moderate and 49 minor ones mostly echo the same two themes at lower volume. Grapefruit and St. John's wort work differently, changing how your body handles the drug rather than adding side effects. Watch for unusual bruising or black stools, and bring your supplement bottles to the counter so your pharmacist can flag the ones that matter.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 285 Minor 49 No known interaction 1,105

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Caffeine: Top Interactions at a Glance

The Aspirin, Caffeine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 347 interacting ingredients — plus 1,105 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Caffeine Combinations Today

The Aspirin, Caffeine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Jequirity + Aspirin, Caffeinei

Evidence from in vitro research suggests that constituents of jequirity beans can inhibit platelet aggregation.

Read the full interaction Moderate Likelihood Possible Sea Buckthorn + Aspirin, Caffeinei

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Red Clover + Aspirin, Caffeinei

Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.

Read the full interaction Moderate Likelihood Possible Ashitaba + Aspirin, Caffeinei

In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.

Read the full interaction Major Likelihood Probable Wine + Aspirin, Caffeinei

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Read the full interaction Moderate Likelihood Possible Safflower + Aspirin, Caffeinei

High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Caffeine

All 1,452 ingredients in our database, ranked by severity — 347 with a Aspirin, Caffeine interaction on file and 1,105 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Caffeine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Jequirity with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that constituents of jequirity beans can inhibit platelet aggregation.

Full Jequirity + Aspirin, Caffeine answer

Can you take Sea Buckthorn with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Sea Buckthorn + Aspirin, Caffeine answer

Can you take Red Clover with Aspirin, Caffeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.

Full Red Clover + Aspirin, Caffeine answer

Can you take Ashitaba with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.

Full Ashitaba + Aspirin, Caffeine answer

Can you take Wine with Aspirin, Caffeine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Wine + Aspirin, Caffeine answer

Can you take Cannabis with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Aspirin, Caffeine answer

Can you take Caprylic Acid with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.

Full Caprylic Acid + Aspirin, Caffeine answer

Can you take Capsicum with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Capsicum + Aspirin, Caffeine answer

Can you take Carrageenan with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.

Full Carrageenan + Aspirin, Caffeine answer

Can you take Cat's Claw with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Aspirin, Caffeine answer

Can you take Catechu with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.

Full Catechu + Aspirin, Caffeine answer

Can you take Cauliflower with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabba...

Full Cauliflower + Aspirin, Caffeine answer

Can you take Celery with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery might increase levels of drugs metabolized by CYP1A2.

Full Celery + Aspirin, Caffeine answer

Can you take Ceylon Leadwort with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.

Full Ceylon Leadwort + Aspirin, Caffeine answer

Can you take Chaga with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Chaga + Aspirin, Caffeine answer

Can you take Chanca Piedra with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.

Full Chanca Piedra + Aspirin, Caffeine answer

Can you take Chokeberry with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Aspirin, Caffeine answer

Can you take Chrysin with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chrysin might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Chrysin + Aspirin, Caffeine answer

Can you take Cilantro with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that extracts of cilantro can inhibit platelet aggregation.

Full Cilantro + Aspirin, Caffeine answer

Can you take Cinchona with Aspirin, Caffeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona might increase the drug effects and risk of bleeding with anticoagulant and antiplatelet drugs.

Full Cinchona + Aspirin, Caffeine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Caffeine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Caffeine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Caffeine sits in 13 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Caffeine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Aspirin, Caffeine through this category.

Related: does Aspirin, Caffeine deplete any nutrients?

Aspirin, Caffeine has 5 reported nutrient associations in the research literature — see the Aspirin, Caffeine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Caffeine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Caffeine.

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Pharmacist Counseling Corner

Aspirin, Caffeine & Supplements: Common Questions

What supplements interact with Aspirin, Caffeine?
In our interaction database, 347 supplement and herbal ingredients have an interaction with Aspirin, Caffeine on file — 13 rated major, 285 moderate, and 49 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Aspirin, Caffeine supplement interactions are the most serious?
The 13 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Danshen — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Caffeine?
That depends entirely on which supplement. The honest answer for Aspirin, Caffeine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Anacin have the same supplement interactions as Aspirin, Caffeine?
Yes — Anacin all contain Aspirin, Caffeine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Caffeine deplete any vitamins or nutrients?
It might — Aspirin, Caffeine has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Caffeine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Caffeine and my other medications?
This page covers Aspirin, Caffeine against supplements and herbal ingredients. Checking Aspirin, Caffeine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 8, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.