Medication interaction hub

What Supplements Interact with Estradiol, Progesterone?

Estradiol, Progesterone brand name: Bijuvanda. Every interaction below applies to the brands too.

206 Interactions 3 Major 165 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Estradiol, Progesterone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Estradiol, Progesterone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Bijuvanda combines estradiol and progesterone, a hormone therapy usually prescribed for menopause symptoms, and its interaction list warrants real care. Three of the 206 supplement ingredients on file carry a major rating, and those deserve your attention first. Grapefruit blocks the enzyme that breaks these hormones down and can push levels higher than intended, St. John's wort does the reverse and can drain the therapy of its effect, and activated charcoal can soak up the dose before your body ever absorbs it.

The 165 moderate entries mostly echo those patterns in gentler form. Some herbs nudge the enzymes that handle these hormones, a few plant extracts act like weak estrogens and compete with the therapy, and because estrogen slows caffeine breakdown, caffeinated drinks and supplements can hit harder than usual. Bulky fiber products can blunt absorption, so space them well apart from your dose; the remaining 38 entries are minor.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 165 Minor 38 No known interaction 1,246

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Estradiol, Progesterone: Top Interactions at a Glance

The Estradiol, Progesterone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 206 interacting ingredients — plus 1,246 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Estradiol, Progesterone Combinations Today

The Estradiol, Progesterone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Rhodiola + Estradiol, Progesteronei

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Read the full interaction Moderate Likelihood Possible Berberine + Estradiol, Progesteronei

Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Saw Palmetto + Estradiol, Progesteronei

Saw palmetto might reduce the effectiveness of estrogens.

Read the full interaction Moderate Likelihood Possible Bitter Melon + Estradiol, Progesteronei

Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Read the full interaction Minor Likelihood Possible Hibiscus Sabdariffa + Estradiol, Progesteronei

Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Goji + Estradiol, Progesteronei

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Estradiol, Progesterone

All 1,452 ingredients in our database, ranked by severity — 206 with a Estradiol, Progesterone interaction on file and 1,246 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Estradiol, Progesterone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Rhodiola with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Full Rhodiola + Estradiol, Progesterone answer

Can you take Berberine with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Estradiol, Progesterone answer

Can you take Saw Palmetto with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Saw palmetto might reduce the effectiveness of estrogens.

Full Saw Palmetto + Estradiol, Progesterone answer

Can you take Bitter Melon with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Estradiol, Progesterone answer

Can you take Hibiscus Sabdariffa with Estradiol, Progesterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP1A2 substrates.

Full Hibiscus Sabdariffa + Estradiol, Progesterone answer

Can you take Terminalia with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Estradiol, Progesterone answer

Can you take Thunder God Vine with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.

Full Thunder God Vine + Estradiol, Progesterone answer

Can you take Thyme with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.

Full Thyme + Estradiol, Progesterone answer

Can you take Tinospora Cordifolia with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.

Full Tinospora Cordifolia + Estradiol, Progesterone answer

Can you take Tragacanth with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Estradiol, Progesterone answer

Can you take Turmeric with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Estradiol, Progesterone answer

Can you take Uva Ursi with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Estradiol, Progesterone answer

Can you take Vitamin E with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Estradiol, Progesterone answer

Can you take Wheatgrass with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Full Wheatgrass + Estradiol, Progesterone answer

Can you take White Pepper with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Estradiol, Progesterone answer

Can you take Wild Cherry with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Estradiol, Progesterone answer

Can you take Wild Yam with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wild yam might increase or decrease the effects of estrogen.

Full Wild Yam + Estradiol, Progesterone answer

Can you take Zedoary with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Estradiol, Progesterone answer

Can you take Zizyphus with Estradiol, Progesterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Estradiol, Progesterone answer

Can you take Thyroid Extract with Estradiol, Progesterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Estradiol, Progesterone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Estradiol, Progesterone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Estradiol, Progesterone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Estradiol, Progesterone sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Estradiol, Progesterone through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Estradiol, Progesterone through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Estradiol, Progesterone through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Estradiol, Progesterone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Estradiol, Progesterone through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Estradiol, Progesterone through this category.

Progesterone 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Estradiol, Progesterone through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Estradiol, Progesterone through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Estradiol, Progesterone through this category.

Related: does Estradiol, Progesterone deplete any nutrients?

Estradiol, Progesterone has 5 reported nutrient associations in the research literature — see the Estradiol, Progesterone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Estradiol, Progesterone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Estradiol, Progesterone.

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Pharmacist Counseling Corner

Estradiol, Progesterone & Supplements: Common Questions

What supplements interact with Estradiol, Progesterone?
Our database currently documents 206 ingredients with a known Estradiol, Progesterone interaction (3 major, 165 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 206. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Estradiol, Progesterone supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Estradiol, Progesterone?
Plenty of supplements coexist fine with Estradiol, Progesterone; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Bijuvanda have the same supplement interactions as Estradiol, Progesterone?
Yes — Bijuvanda all contain Estradiol, Progesterone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Estradiol, Progesterone deplete any vitamins or nutrients?
It might — Estradiol, Progesterone has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Estradiol, Progesterone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Estradiol, Progesterone and my other medications?
This page covers Estradiol, Progesterone against supplements and herbal ingredients. Checking Estradiol, Progesterone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.