Doxepin

Name: Doxepin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

123 interactions 6 explained in plain English

Also sold as: Prudoxin Zonalon

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Linezolid Injection Ketorolac Injection Dacomitinib Palonosetron Injection

3 Contraindicated 114 Major 3 Moderate 3 Minor

All (123) Contraindicated (3) Major (114) Moderate (3) Minor (3)

Contraindicated

Doxepin Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Doxepin Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Doxepin Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.