Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

C
Clovoxamine 2 Cloxacillin 18 Cloxazolam 7 Clozapine 114 Cobicistat 129 Cobimetinib 123 Cocaine 19 Codeine 55 Coenzyme Q10 5 Colchicine 223 Colesevelam 49 Colestipol 50 Colistimethate Injection 24 Colistimethate Sodium 5 Collagenase, Clostridium Histolyticum 10 Conivaptan 125 Conjugated / Estrogens 5 Conjugated Estrogens Synthetic A 2 Conjugated Estrogens Synthetic B 3 Copanlisib 3 Copper 1 Copper Cu 64 Dotatate 3 Corticotropin 12 Cortisone 21 Cosyntropin 50 Coumarin 1 Cranberry 1 Cranberry Juice 1 Crinecerfont 2 Crizotinib 138 Curcumin 22 Cyanocobalamin 7 Cyanocobalamin Injection 5 Cyanocobalamin Nasal Gel 5 Cyclacillin 11 Cyclizine 2 Cyclobenzaprine 97 Cyclopenthiazide 44 Cyclopentolate 12 Cyclopentolate Ophthalmic 46 Cyclophosphamide 88 Cyclophosphamide Injection 84 Cycloserine 1 Cyclosporine 174 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Cyclothiazide 46 Cyproheptadine 30 Cysteamine 2 Cytarabine 22 Cytarabine Liposome 1
D
Dabigatran 284 Dabigatran Etexilate 314 Dabigatran Etexilate Mesylate 6 Dabrafenib 133 Dacarbazine 17 Daclatasvir 26 Dacomitinib 56 Dactinomycin 20 Dalfampridine 11 Dalfopristin 20 Dalteparin 55 Dalteparin Injection 177 Danaparoid 57 Danazol 28 Dandelion 26 Danicopan 12 Dantrolene 21 Dapagliflozin 98 Dapiprazole 5 Daprodustat 12 Dapsone 15 Dapsone Topical 14 Daptomycin 8 Daptomycin Injection 8 Daratumumab Injection 15 Daridorexant 66 Darifenacin 23 Darolutamide 105 Darunavir 115 Dasabuvir 21 Dasatinib 342 Daunorubicin 21 Daunorubicin Citrate Liposome 1 Daunorubicin Liposome 1 Decamethonium 5 Decitabine Injection 15 Defactinib 16 Deferasirox 43 Deferiprone 19 Deferoxamine 5 Deferoxamine Mesylate 1 Defibrotide 22 Defibrotide Injection 87 Deflazacort 228 Degarelix 62 Degarelix Injection 226 Dehydroepiandrosterone 5 Delafloxacin 52 Delafloxacin Injection 45 Delamanid 64 Delapril 5 Delavirdine 50 Delorazepam 7 Demecarium 1 Demeclocycline 63 Dengue Tetravalent Vaccine, Live 204 Dermatan Sulfate 4 Desflurane 76 Desipramine 114 Desirudin 50 Deslanoside 12 Desloratadine 9 Deslorelin 18 Desmopressin 73 Desmopressin Nasal 196 Desogestrel 46 Desonide 33 Desonide Topical 30 Desoximetasone 32