Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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Desoximetasone Topical 29 Desvenlafaxine 68 Deucravacitinib 18 Deuruxolitinib 50 Deutetrabenazine 262 Deutivacaftor 35 Dexamethasone 74 Dexamethasone Injection 308 Dexamethasone Ophthalmic 308 Dexbrompheniramine 1 Dexchlorpheniramine 1 Dexfenfluramine 3 Dexibuprofen 87 Dexketoprofen 91 Dexlansoprazole 77 Dexmedetomidine 81 Dexmethylphenidate 6 Dexmethylphenidate Hydrochloride 1 Dextran 2 Dextroamphetamine 56 Dextromethorphan 20 Dezocine 11 Diacetylmorphine 20 Diatrizoate 1 Diazepam 40 Diazepam Nasal Spray 281 Diazepam Rectal 281 Diazoxide 47 Dibekacin 11 Dibenzepin 57 Dichloralphenazone 19 Dichlorphenamide 8 Diclofenac 99 Diclofenac Ophthalmic 268 Diclofenac Topical (Actinic Keratosis) 268 Diclofenac Topical (Arthritis Pain) 268 Diclofenac Transdermal Patch 268 Dicloxacillin 31 Dicumarol 61 Dicyclomine 12 Didanosine 68 Dienestrol 4 Dienogest 47 Diethylpropion 21 Diethylstilbestrol 4 Difenoxin 31 Diflorasone 6 Diflorasone Topical 29 Diflucortolone 5 Diflunisal 100 Difluprednate 6 Difluprednate Ophthalmic 29 Digitalis 1 Digitoxin 14 Digoxin 453 Dihydroartemisinin 2 Dihydrocodeine 54 Dihydroergotamine 30 Dihydroergotamine Injection 157 Dihydroergotamine Nasal Spray 157 Dihydrotachysterol 1 Dihydroxyaluminum Aminoacetate 57 Dihydroxyaluminum Sodium Carbonate 57 Dilevalol 10 Diltiazem 92 Dimenhydrinate 11 Dimethindene 1 Dinoprostone 8 Dinutuximab Injection 15 Diosmin 12 Diphenhydramine 28 Diphenhydramine Injection 123 Diphenhydramine Topical 123 Diphenoxylate 31 Diphenylpyraline 1 Diphtheria Toxoid, Adsorbed 2 Dipivefrin Ophthalmic 2 Dipyridamole 191 Dipyrone 116 Dirithromycin 3 Disopyramide 284 Distigmine 2 Disulfiram 45 Divalproex Sodium 6 Dixyrazine 4 Dobutamine 14 Docetaxel 129 Docetaxel Injection 122 Docusate 1 Dofetilide 454 Dolasetron 332 Dolasetron Injection 296 Dolutegravir 51 Domperidone 75 Donanemab-Azbt 19 Donepezil 105 Dong Quai 13 Dopamine 19 Doravirine 57 Dordaviprone 69 Doripenem Injection 3 Dorzolamide 4 Dorzolamide Ophthalmic 4 Dostarlimab-Gxly Injection 15 Dothiepin 32 Doxacurium 16 Doxazosin 47 Doxepin 123 Doxercalciferol 7 Doxercalciferol Injection 5 Doxifluridine 36 Doxofylline 1 Doxorubicin 237 Doxorubicin Hydrochloride Liposome 40 Doxycycline 40 Doxycycline Injection 118 Doxylamine 24 Dronabinol 23 Dronedarone 146 Droperidol 91