Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

D
Drospirenone 48 Drotrecogin Alfa 12 Droxicam 92 Droxidopa 23 Dulaglutide 43 Dulaglutide Injection 86 Duloxetine 77 Dupilumab Injection 22 Durvalumab Injection 15 Dutasteride 10 Duvelisib 51
E
Ebastine 41 Ebola Zaire Vaccine, Live 194 Ebrotidine 7 Echinacea 23 Echothiophate 1 Eculizumab 1 Edoxaban 244 Efavirenz 137 Efgartigimod Alfa-Fcab Injection 19 Elacestrant 123 Elafibranor 21 Elagolix 57 Elbasvir 10 Eletriptan 30 Elexacaftor 22 Eliglustat 17 Elinzanetant 35 Elivaldogene Autotemcel Injection 43 Elotuzumab Injection 15 Eltrombopag 20 Eluxadoline 26 Elvitegravir 19 Emapalumab-Lzsg Injection 16 Emedastine 1 Empagliflozin 104 Emtricitabine 106 Enalapril 198 Enalapril Maleate 7 Enalaprilat 66 Enasidenib 168 Encainide 9 Enclomiphene 1 Encorafenib 468 Enflurane 37 Enfortumab Vedotin 1 Enfortumab Vedotin-Ejfv 2 Enfuvirtide 1 Enfuvirtide Injection 4 Enoxacin 34 Enoxaparin 201 Enoxaparin Injection 177 Enoximone 1 Ensartinib 26 Ensitrelvir 126 Entacapone 57 Entecavir 5 Entrectinib 361 Enzalutamide 120 Ephedrine 8 Ephedrine Hydrochloride 1 Ephedrine Sulfate 1 Epinastine 1 Epinastine Ophthalmic 7 Epinephrine 31 Epirubicin 37 Eplerenone 55 Epoprostenol 152 Eprosartan 122 Eptifibatide 52 Eravacycline 19 Eravacycline Injection 60 Erdafitinib 152 Ergocalciferol 2 Ergoloid Mesylates 11 Ergonovine 14 Ergotamine 26 Eribulin 41 Eribulin Injection 169 Erlotinib 83 Ertapenem Injection 4 Ertugliflozin 89 Erythrityl Tetranitrate 1 Erythromycin 186 Escitalopram 136 Esketamine 29 Esketamine Nasal Spray 194 Eslicarbazepine Acetate 39 Esmolol 191 Esomeprazole 106 Esomeprazole Injection 95 Estazolam 22 Esterified Estrogens 5 Estetrol 26 Estradiol 216 Estradiol Topical 194 Estradiol Transdermal Patch 194 Estramustine 34 Estriol 5 Estrone 2 Estropipate 4 Eszopiclone 24 Etanercept 8 Eterobarb 5 Ethacrynic Acid 57 Ethambutol 12 Ethanol 3 Ethchlorvynol 22 Ethinyl Estradiol 102 Ethiodized Oil 1 Ethopropazine 26 Ethosuximide 14 Ethotoin 2 Ethylestrenol 1 Ethylmorphine 29 Ethynodiol 46 Etidronate 12 Etodolac 290 Etofenamate 92 Etomidate 5