Medication interaction hub

What Supplements Interact with Atenolol, Chlorthalidone?

Atenolol, Chlorthalidone brand name: Tenoretic. Every interaction below applies to the brands too.

229 Interactions 9 Major 197 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Atenolol, Chlorthalidone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Atenolol, Chlorthalidone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tenoretic combines two blood pressure drugs, the beta-blocker atenolol and the diuretic chlorthalidone, which gives supplements two separate ways to interfere, and I would treat this list with genuine care. Of the 229 ingredients on file, the bulk either add to its blood-pressure-lowering effect or pile onto what the diuretic does to fluid and minerals, and nine carry a major rating. Those nine are the ones to understand first.

Some herbs drive potassium down further than the diuretic does, while calcium sources like dolomite can push blood calcium dangerously high because chlorthalidone slows how the kidneys clear it. Activated charcoal can bind the medication in the gut and block it from getting in, so keep the two well spaced. Most of the rest, 197 moderate and 23 minor, echo the additive blood pressure theme, plus about 20 ingredients that raise sun sensitivity, worth remembering in strong sun.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 197 Minor 23 No known interaction 1,223

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Atenolol, Chlorthalidone: Top Interactions at a Glance

The Atenolol, Chlorthalidone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 229 interacting ingredients — plus 1,223 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Atenolol, Chlorthalidone Combinations Today

The Atenolol, Chlorthalidone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Calcium + Atenolol, Chlorthalidonei

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Read the full interaction Moderate Likelihood Probable Vitamin D + Atenolol, Chlorthalidonei

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Read the full interaction Moderate Likelihood Probable Fish Oil + Atenolol, Chlorthalidonei

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Atenolol, Chlorthalidonei

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Sodium + Atenolol, Chlorthalidonei

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Agmatine + Atenolol, Chlorthalidonei

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Atenolol, Chlorthalidone

All 1,452 ingredients in our database, ranked by severity — 229 with a Atenolol, Chlorthalidone interaction on file and 1,223 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Atenolol, Chlorthalidone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Full Calcium + Atenolol, Chlorthalidone answer

Can you take Vitamin D with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Full Vitamin D + Atenolol, Chlorthalidone answer

Can you take Fish Oil with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Atenolol, Chlorthalidone answer

Can you take Coenzyme Q10 with Atenolol, Chlorthalidone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Atenolol, Chlorthalidone answer

Can you take Sodium with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Atenolol, Chlorthalidone answer

Can you take Malic Acid with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.

Full Malic Acid + Atenolol, Chlorthalidone answer

Can you take Manna with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, manna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Manna + Atenolol, Chlorthalidone answer

Can you take Melatonin with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Full Melatonin + Atenolol, Chlorthalidone answer

Can you take N-acetyl Cysteine (nac) with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.

Full N-acetyl Cysteine (nac) + Atenolol, Chlorthalidone answer

Can you take Nattokinase with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.

Full Nattokinase + Atenolol, Chlorthalidone answer

Can you take Niacin with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Atenolol, Chlorthalidone answer

Can you take Noni with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.

Full Noni + Atenolol, Chlorthalidone answer

Can you take Octopamine with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In humans, octopamine 450-600 mg daily increases blood pressure in hypotensive patients.

Full Octopamine + Atenolol, Chlorthalidone answer

Can you take Oolong Tea with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.

Full Oolong Tea + Atenolol, Chlorthalidone answer

Can you take Oregon Grape with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.

Full Oregon Grape + Atenolol, Chlorthalidone answer

Can you take Parsley with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.

Full Parsley + Atenolol, Chlorthalidone answer

Can you take Pheasant's Eye with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pheasant's eye with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Full Pheasant's Eye + Atenolol, Chlorthalidone answer

Can you take Phellodendron with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might have additive effects with antihypertensive drugs.

Full Phellodendron + Atenolol, Chlorthalidone answer

Can you take Pleurisy Root with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to...

Full Pleurisy Root + Atenolol, Chlorthalidone answer

Can you take Pomegranate with Atenolol, Chlorthalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Full Pomegranate + Atenolol, Chlorthalidone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Atenolol, Chlorthalidone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Atenolol, Chlorthalidone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Atenolol, Chlorthalidone sits in 8 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Atenolol, Chlorthalidone through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Atenolol, Chlorthalidone through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Atenolol, Chlorthalidone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Atenolol, Chlorthalidone through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Atenolol, Chlorthalidone through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Atenolol, Chlorthalidone through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Atenolol, Chlorthalidone through this category.

Atenolol (Tenormin) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Atenolol, Chlorthalidone through this category.

Related: does Atenolol, Chlorthalidone deplete any nutrients?

Atenolol, Chlorthalidone has 8 reported nutrient associations in the research literature — see the Atenolol, Chlorthalidone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Atenolol, Chlorthalidone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Atenolol, Chlorthalidone.

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Products that contain Atenolol, Chlorthalidone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Atenolol, Chlorthalidone.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Atenolol, Chlorthalidone & Supplements: Common Questions

What supplements interact with Atenolol, Chlorthalidone?
More than you might expect — 229 in total, though they are far from equal: 9 are rated major, 197 moderate, and 23 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Atenolol, Chlorthalidone supplement interactions are the most serious?
Focus on the major group: American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Dolomite, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Atenolol, Chlorthalidone?
Usually yes — most people on Atenolol, Chlorthalidone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Tenoretic have the same supplement interactions as Atenolol, Chlorthalidone?
Yes — Tenoretic all contain Atenolol, Chlorthalidone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Atenolol, Chlorthalidone deplete any vitamins or nutrients?
It might — Atenolol, Chlorthalidone has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Atenolol, Chlorthalidone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Atenolol, Chlorthalidone and my other medications?
This page covers Atenolol, Chlorthalidone against supplements and herbal ingredients. Checking Atenolol, Chlorthalidone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.