Medication interaction hub

What Supplements Interact with Deflazacort?

Deflazacort brand name: Emflaza. Every interaction below applies to the brands too.

180 Interactions 3 Major 139 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Deflazacort? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Deflazacort against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Deflazacort (Emflaza) is a corticosteroid, best known for treating Duchenne muscular dystrophy, and the liver clears it through the CYP3A4 enzyme, so supplements that block or speed up that enzyme can genuinely shift how much of the drug reaches the blood. That earns this page real caution. Three of the 180 ingredients on file rate major: grapefruit can push deflazacort levels up, St. John's wort can drain them down, and activated charcoal can keep a dose from absorbing at all. Understand those three before anything else on the list.

Most of the 139 moderate entries replay that enzyme story at lower stakes, while a group of 53 immune-stimulating herbs may work against the immune-calming effect that makes this steroid useful in the first place. The remaining 38 rate minor, but with three major entries in play, grapefruit is the everyday item I would drop first.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 139 Minor 38 No known interaction 1,272

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Deflazacort: Top Interactions at a Glance

The Deflazacort supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 180 interacting ingredients — plus 1,272 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Deflazacort Combinations Today

The Deflazacort + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Shark Cartilage + Deflazacorti

Theoretically, shark cartilage might interfere with immunosuppressive therapy.

Read the full interaction Minor Likelihood Possible Yohimbe + Deflazacorti

Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Glyconutrients + Deflazacorti

Evidence from in vitro research suggests that glyconutrients stimulate certain immune responses.

Read the full interaction Minor Likelihood Unlikely Milk Thistle + Deflazacorti

It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Read the full interaction Moderate Likelihood Possible Umckaloabo + Deflazacorti

Theoretically, Pelargonium sidoides might decrease the effectiveness of immunosuppressant therapy.

Read the full interaction Major Likelihood Likely Grapefruit + Deflazacorti

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Deflazacort

All 1,452 ingredients in our database, ranked by severity — 180 with a Deflazacort interaction on file and 1,272 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Deflazacort?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Shark Cartilage with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, shark cartilage might interfere with immunosuppressive therapy.

Full Shark Cartilage + Deflazacort answer

Can you take Yohimbe with Deflazacort?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Deflazacort answer

Can you take Glyconutrients with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that glyconutrients stimulate certain immune responses.

Full Glyconutrients + Deflazacort answer

Can you take Milk Thistle with Deflazacort?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Deflazacort answer

Can you take Umckaloabo with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Pelargonium sidoides might decrease the effectiveness of immunosuppressant therapy.

Full Umckaloabo + Deflazacort answer

Can you take Propolis with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.

Full Propolis + Deflazacort answer

Can you take Quercetin with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Deflazacort answer

Can you take Quillaia with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of quillaia with immunosuppressant drugs might decrease the effectiveness of these drugs.

Full Quillaia + Deflazacort answer

Can you take Rabdosia Rubescens with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Deflazacort answer

Can you take Resveratrol with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Deflazacort answer

Can you take Rhodiola with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Full Rhodiola + Deflazacort answer

Can you take Rice Bran Arabinoxylan Compound with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Full Rice Bran Arabinoxylan Compound + Deflazacort answer

Can you take Rooibos with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Full Rooibos + Deflazacort answer

Can you take Sage with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Sage + Deflazacort answer

Can you take Schizonepeta with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Deflazacort answer

Can you take Selenium with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.

Full Selenium + Deflazacort answer

Can you take Shiitake Mushroom with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.

Full Shiitake Mushroom + Deflazacort answer

Can you take Slippery Elm with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Deflazacort answer

Can you take Sulforaphane with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Deflazacort answer

Can you take Sweet Annie with Deflazacort?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Deflazacort answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Deflazacort is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Deflazacort, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Deflazacort sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Deflazacort through this category.

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Deflazacort through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Deflazacort through this category.

About Deflazacort

Deflazacort is a corticosteroid used to treat Duchenne muscular dystrophy (DMD) in eligible pediatric patients, available across multiple brand products in tablet and oral suspension forms.

Generic name: Deflazacort  ·  Brand name: Emflaza.

See the full Deflazacort drug information
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Take a Supplement Product? Check the Whole Bottle Against Deflazacort

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Deflazacort.

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Pharmacist Counseling Corner

Deflazacort & Supplements: Common Questions

What supplements interact with Deflazacort?
In our interaction database, 180 supplement and herbal ingredients have an interaction with Deflazacort on file — 3 rated major, 139 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Deflazacort supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Deflazacort?
That depends entirely on which supplement. The honest answer for Deflazacort is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Emflaza have the same supplement interactions as Deflazacort?
Yes — Emflaza all contain Deflazacort, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Deflazacort and my other medications?
This page covers Deflazacort against supplements and herbal ingredients. Checking Deflazacort against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Deflazacort drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.