Medication interaction hub

What Supplements Interact with Insulin Lispro-Aabc?

Insulin Lispro-Aabc brand name: Lyumjev. Every interaction below applies to the brands too.

239 Interactions 1 Major 208 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin Lispro-Aabc? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin Lispro-Aabc against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Lyumjev (insulin lispro-aabc) is an ultra rapid mealtime insulin, built to drop blood sugar quickly, which is why its 239 interacting supplements call for genuine care. Nearly all of them work on the same axis. Most lower glucose on their own and can stack with the insulin to cause a low, while a smaller group, niacin among them, pushes blood sugar up and can weaken the dose you counted on. The one major-rated entry, Siberian cocklebur, has caused severe, dangerous drops in blood sugar in people and should not be taken with insulin at all.

The remaining 208 moderate and 30 minor entries mostly rest on small studies or theory, but a fast insulin leaves little margin, and a low can arrive within the hour of a dose. Learn the cocklebur warning first, then treat any glucose-lowering herb as part of your mealtime dosing math.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 208 Minor 30 No known interaction 1,213

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Insulin Lispro-Aabc: Top Interactions at a Glance

The Insulin Lispro-Aabc supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 239 interacting ingredients — plus 1,213 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Insulin Lispro-Aabc Combinations Today

The Insulin Lispro-Aabc + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Papaya + Insulin Lispro-Aabci

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.

Read the full interaction Moderate Likelihood Possible Winter Cherry + Insulin Lispro-Aabci

In animal diabetic models, winter cherry extract decreases blood glucose.

Read the full interaction Moderate Likelihood Possible Chirata + Insulin Lispro-Aabci

Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Kousso + Insulin Lispro-Aabci

Theoretically, kousso might have an additive effect with antidiabetes drugs and cause hypoglycemia.

Read the full interaction Minor Likelihood Unlikely Glucosamine + Insulin Lispro-Aabci

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.

Read the full interaction Minor Likelihood Possible Stevia + Insulin Lispro-Aabci

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin Lispro-Aabc

All 1,452 ingredients in our database, ranked by severity — 239 with a Insulin Lispro-Aabc interaction on file and 1,213 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin Lispro-Aabc?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Papaya with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.

Full Papaya + Insulin Lispro-Aabc answer

Can you take Winter Cherry with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal diabetic models, winter cherry extract decreases blood glucose.

Full Winter Cherry + Insulin Lispro-Aabc answer

Can you take Chirata with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Full Chirata + Insulin Lispro-Aabc answer

Can you take Kousso with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kousso might have an additive effect with antidiabetes drugs and cause hypoglycemia.

Full Kousso + Insulin Lispro-Aabc answer

Can you take Glucosamine with Insulin Lispro-Aabc?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.

Full Glucosamine + Insulin Lispro-Aabc answer

Can you take Oolong Tea with Insulin Lispro-Aabc?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking oolong tea with antidiabetes drugs might interfere with blood glucose control.

Full Oolong Tea + Insulin Lispro-Aabc answer

Can you take Pu-erh Tea with Insulin Lispro-Aabc?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking pu-erh tea with antidiabetes drugs might interfere with blood glucose control.

Full Pu-erh Tea + Insulin Lispro-Aabc answer

Can you take Yerba Mate with Insulin Lispro-Aabc?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking yerba mate with antidiabetes drugs might interfere with blood glucose control.

Full Yerba Mate + Insulin Lispro-Aabc answer

Can you take Siberian Cocklebur with Insulin Lispro-Aabc?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Full Siberian Cocklebur + Insulin Lispro-Aabc answer

Can you take American Ginseng with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Full American Ginseng + Insulin Lispro-Aabc answer

Can you take Astragalus with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Astragalus + Insulin Lispro-Aabc answer

Can you take Banaba with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.

Full Banaba + Insulin Lispro-Aabc answer

Can you take Beer with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Beer + Insulin Lispro-Aabc answer

Can you take Bitter Melon with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.

Full Bitter Melon + Insulin Lispro-Aabc answer

Can you take Branched-chain Amino Acids (bcaa) with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BCAAs might alter the effects of antidiabetes medications.

Full Branched-chain Amino Acids (bcaa) + Insulin Lispro-Aabc answer

Can you take Cumin with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cumin + Insulin Lispro-Aabc answer

Can you take Ephedra with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ephedra with antidiabetes drugs might interfere with blood glucose control.

Full Ephedra + Insulin Lispro-Aabc answer

Can you take Fenugreek with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.

Full Fenugreek + Insulin Lispro-Aabc answer

Can you take Fig with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.

Full Fig + Insulin Lispro-Aabc answer

Can you take Flaxseed with Insulin Lispro-Aabc?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.

Full Flaxseed + Insulin Lispro-Aabc answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin Lispro-Aabc is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin Lispro-Aabc, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin Lispro-Aabc sits in 1 interaction category. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin Lispro-Aabc through this category.

Related: does Insulin Lispro-Aabc deplete any nutrients?

Insulin Lispro-Aabc has 1 reported nutrient association in the research literature — see the Insulin Lispro-Aabc nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Insulin Lispro-Aabc

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin Lispro-Aabc.

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Pharmacist Counseling Corner

Insulin Lispro-Aabc & Supplements: Common Questions

What supplements interact with Insulin Lispro-Aabc?
More than you might expect — 239 in total, though they are far from equal: 1 are rated major, 208 moderate, and 30 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, American Ginseng, Astragalus.
Which Insulin Lispro-Aabc supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin Lispro-Aabc?
Usually yes — most people on Insulin Lispro-Aabc can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Lyumjev have the same supplement interactions as Insulin Lispro-Aabc?
Yes — Lyumjev all contain Insulin Lispro-Aabc, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin Lispro-Aabc deplete any vitamins or nutrients?
It might — Insulin Lispro-Aabc has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin Lispro-Aabc nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin Lispro-Aabc and my other medications?
This page covers Insulin Lispro-Aabc against supplements and herbal ingredients. Checking Insulin Lispro-Aabc against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.