Doxepin
123 interactions 6 explained in plain English
Also sold as:
Prudoxin
Zonalon
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Injection
Metoclopramide Nasal Spray
Linezolid Injection
Ketorolac Injection
Dacomitinib
Palonosetron Injection
Contraindicated
Doxepin Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Doxepin Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Doxepin Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Doxepin Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus, an increased risk of serotonin syndrome, an increased codeine exposure, reduced active metab... Details Doxepin Amitriptyline Elavil Explained An increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Doxepin Sertraline Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Doxepin Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Doxepin Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome, an increased risk of paralytic ileus and a... Details Doxepin Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Doxepin Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Doxepin Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Aripiprazole Injection Abilify An increased risk of CNS depression and an increased risk of QT interval prolongation Details Doxepin Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Asenapine Transdermal Patch Secuado Increased doxepin exposure, an increased asenapine exposure, an increased risk of CNS depression and an increased risk of QT inter... Details Doxepin Aspirin Acuprin® An increased risk of bleeding Details Doxepin Aspirin Rectal Aspirin An increased risk of bleeding Details Doxepin Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Doxepin Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Doxepin Alfuzosin UroXatral An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Anagrelide Agrylin Increased risk of QT interval prolongation Details Doxepin Bedaquiline Sirturo Increased risk of QT interval prolongation Details Doxepin Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Doxepin Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Doxepin Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Doxepin Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Doxepin Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Doxepin Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Doxepin Dacomitinib Vizimpro Increased doxepin exposure and an increased risk of doxepin-related adverse reactions Details Doxepin Dasatinib Phyrago An increased risk of QT interval prolongation Details Doxepin Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Doxepin Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Doxepin Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Doxepin Diazepam Rectal Diastat An increased risk of CNS depression Details Doxepin Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Doxepin Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Doxepin Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Doxepin Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Doxepin Diphenhydramine Injection Banophen An increased risk of CNS depression Details Doxepin Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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