Doxepin
123 interactions 6 explained in plain English
Also sold as:
Prudoxin
Zonalon
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Injection
Metoclopramide Nasal Spray
Linezolid Injection
Ketorolac Injection
Dacomitinib
Palonosetron Injection
Major
Doxepin Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Dolasetron Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Doxepin Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Doxepin Encorafenib Braftovi Increased risk of QT interval prolongation Details Doxepin Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Doxepin Eribulin Injection Halaven An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Doxepin Etodolac Lodine An increased risk of bleeding Details Doxepin Famotidine Calmicid An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Famotidine Injection Calmicid An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Felbamate Felbatol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Fenoprofen Fenopron An increased risk of bleeding Details Doxepin Fentanyl Transdermal Patch Duragesic® An increased risk of paralytic ileus, an increased risk of serotonin syndrome and an increased risk of CNS depression Details Doxepin Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Flurbiprofen Ansaid An increased risk of bleeding Details Doxepin Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Doxepin Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Fostemsavir Rukobia Increased risk of torsade de pointes Details Doxepin Galantamine Razadyne An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Glasdegib Daurismo Increased risk of QT interval prolongation Details Doxepin Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Doxepin Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Doxepin Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Doxepin Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Doxepin Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Doxepin Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome and QT-interval prolongation Details Doxepin Granisetron Injection Granisol Increased risk of serotonin syndrome and QT-interval prolongation Details Doxepin Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Doxepin Hydromorphone Injection Dilaudid An increased risk of paralytic ileus, an increased risk of serotonin syndrome and an increased risk of CNS depression Details Doxepin Hydromorphone Rectal available generically An increased risk of paralytic ileus, an increased risk of serotonin syndrome and an increased risk of CNS depression Details Doxepin Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Doxepin Ibuprofen Addaprin An increased risk of bleeding Details Doxepin Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Doxepin Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Ivabradine Corlanor Increased risk of QT prolongation Details Doxepin Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Doxepin Ketoprofen Actron® An increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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