Doxepin

123 interactions 6 explained in plain English
Also sold as: Prudoxin Zonalon
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Doxepin Ketorolac Acular An increased risk of bleeding Details Doxepin Ketorolac Injection Acular An increased risk of bleeding Details Doxepin Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Doxepin Ketorolac Ophthalmic Acular An increased risk of bleeding Details Doxepin Lefamulin Xenleta Increased risk of QT interval prolongation Details Doxepin Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Doxepin Levofloxacin Levaquin Increased risk of QT interval prolongation Details Doxepin Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Doxepin Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Doxepin Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Doxepin Meclofenamate Meclodium® An increased risk of bleeding Details Doxepin Mefenamic Acid Ponstel® An increased risk of bleeding Details Doxepin Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Meloxicam Alloxate An increased risk of bleeding Details Doxepin Meloxicam Injection Alloxate An increased risk of bleeding Details Doxepin Metronidazole Flagyl An increased risk of QT interval prolongation Details Doxepin Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Doxepin Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Doxepin Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Doxepin Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Doxepin Midazolam Injection Nayzilam An increased risk of CNS depression Details Doxepin Morphine Injection Astramorph® PF An increased risk of urinary retention, severe constipation, paralytic ileus, an increased risk of serotonin syndrome and an incre... Details Doxepin Moxifloxacin Avelox Increased risk of QT interval prolongation Details Doxepin Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Doxepin Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Doxepin Nabumetone Relafen An increased risk of bleeding Details Doxepin Nalbuphine Injection Nubain® An increased risk of paralytic ileus, an increased risk of serotonin syndrome and an increased risk of CNS depression Details Doxepin Naproxen Aleve An increased risk of bleeding Details Doxepin Nebivolol Bystolic Increased exposure to nebivolol Details Doxepin Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Ofloxacin Floxin® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Ofloxacin Ophthalmic Ocuflox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Ofloxacin Otic Floxin® Otic An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Doxepin Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation, an increased risk of ventricular arrhythmias and potentiated cardiovascular effects Details Doxepin Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Doxepin Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.