Medication interaction hub

What Supplements Interact with Irinotecan Hydrochloride?

135 Interactions 4 Major 100 Moderate 31 Minor
Curated & coded by · Clinical Pharmacist · Updated September 30, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Irinotecan Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Irinotecan Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Irinotecan hydrochloride is chemotherapy, most often used against colorectal cancer, so the 135 supplements and foods on this page call for genuine care rather than a shrug. Four entries rate major, and St. John's wort is the one to understand first, since human research shows it cuts irinotecan levels by at least half, quietly weakening the treatment itself. Grapefruit pushes the opposite way, blocking the CYP3A4 enzyme so drug levels climb and side effects along with them.

Most of the rest works through the same machinery. Some 121 ingredients affect CYP3A4, another 17 involve OATP, a gut transporter that controls how much of an oral drug is absorbed (apple juice sits in that group at major severity), and a dozen speed elimination through glucuronidation. The 100 moderate and 31 minor entries carry lower stakes one by one, but chemotherapy leaves little room for a dose running weak or hot, so review this page with your oncology team before starting anything on it.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 100 Minor 31 No known interaction 1,317

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Irinotecan Hydrochloride: Top Interactions at a Glance

The Irinotecan Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 135 interacting ingredients — plus 1,317 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Irinotecan Hydrochloride Combinations Today

The Irinotecan Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Apple + Irinotecan Hydrochloridei

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Read the full interaction Moderate Likelihood Possible Glucosamine + Irinotecan Hydrochloridei

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.

Read the full interaction Minor Likelihood Possible Black Cohosh + Irinotecan Hydrochloridei

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.

Read the full interaction Major Likelihood Likely Sweet Orange + Irinotecan Hydrochloridei

Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Read the full interaction Moderate Likelihood Possible Oregon Grape + Irinotecan Hydrochloridei

Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Ginkgo + Irinotecan Hydrochloridei

Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Irinotecan Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 135 with a Irinotecan Hydrochloride interaction on file and 1,317 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Irinotecan Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Apple with Irinotecan Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Full Apple + Irinotecan Hydrochloride answer

Can you take Glucosamine with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.

Full Glucosamine + Irinotecan Hydrochloride answer

Can you take Black Cohosh with Irinotecan Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.

Full Black Cohosh + Irinotecan Hydrochloride answer

Can you take Sweet Orange with Irinotecan Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Full Sweet Orange + Irinotecan Hydrochloride answer

Can you take Oregon Grape with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Irinotecan Hydrochloride answer

Can you take Fennel with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Irinotecan Hydrochloride answer

Can you take Feverfew with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Irinotecan Hydrochloride answer

Can you take Fo-ti with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Irinotecan Hydrochloride answer

Can you take Garlic with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Irinotecan Hydrochloride answer

Can you take German Chamomile with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Irinotecan Hydrochloride answer

Can you take Ginger with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Irinotecan Hydrochloride answer

Can you take Ginkgo with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Irinotecan Hydrochloride answer

Can you take Goji with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Irinotecan Hydrochloride answer

Can you take Goldenseal with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Irinotecan Hydrochloride answer

Can you take Goldthread with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Irinotecan Hydrochloride answer

Can you take Grape with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Irinotecan Hydrochloride answer

Can you take Higenamine with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Irinotecan Hydrochloride answer

Can you take Horny Goat Weed with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Irinotecan Hydrochloride answer

Can you take Hu Zhang with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.

Full Hu Zhang + Irinotecan Hydrochloride answer

Can you take Indian Long Pepper with Irinotecan Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + Irinotecan Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Irinotecan Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Irinotecan Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Irinotecan Hydrochloride sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Irinotecan Hydrochloride through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Irinotecan Hydrochloride through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Irinotecan Hydrochloride through this category.

Irinotecan (Camptosar) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Irinotecan Hydrochloride through this category.

Topoisomerase I Inhibitors 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Irinotecan Hydrochloride through this category.

Topoisomerase Ii Inhibitors 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Irinotecan Hydrochloride through this category.

About Irinotecan Hydrochloride

Irinotecan Hydrochloride is a prescription medication. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

See the full Irinotecan Lipid Complex Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Irinotecan Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Irinotecan Hydrochloride.

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Pharmacist Counseling Corner

Irinotecan Hydrochloride & Supplements: Common Questions

What supplements interact with Irinotecan Hydrochloride?
Our database currently documents 135 ingredients with a known Irinotecan Hydrochloride interaction (4 major, 100 moderate, 31 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 135. The highest-ranked right now: Apple, Grapefruit, St. John's Wort.
Which Irinotecan Hydrochloride supplement interactions are the most serious?
The 4 major-rated combinations — led by Apple, Grapefruit, St. John's Wort and Sweet Orange — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Irinotecan Hydrochloride?
Plenty of supplements coexist fine with Irinotecan Hydrochloride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Irinotecan Hydrochloride and my other medications?
This page covers Irinotecan Hydrochloride against supplements and herbal ingredients. Checking Irinotecan Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Irinotecan Lipid Complex Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 30, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.