Medication interaction hub

What Supplements Interact with Ozanimod Hydrochloride?

Ozanimod Hydrochloride brand name: Zeposia. Every interaction below applies to the brands too.

159 Interactions 20 Major 127 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated September 27, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ozanimod Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ozanimod Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People taking ozanimod (Zeposia) for multiple sclerosis or ulcerative colitis often reach for immune boosters, protein powders, or herbal energy blends, and that is where this list demands real attention. Twenty of the 159 supplements on file carry a major rating, and the loudest theme is blood pressure. Ozanimod acts like an MAO inhibitor in the body, so tyramine-rich products such as fermented soy and brewer's yeast can trigger a dangerous pressure spike. A second major-rated cluster, grapefruit among them, can stretch the heart's electrical rhythm and raise the risk of serious arrhythmias.

Alcohol and a run of liver-stressing herbs add strain to an organ this drug can already tax, and among the 127 moderate and 12 minor entries sit 53 ingredients that deepen immune suppression from a medication built to quiet the immune system. Start with the major-rated names below and check them against every bottle you take.

— , Clinical Pharmacist · July 18, 2026

Major 20 Moderate 127 Minor 12 No known interaction 1,293

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ozanimod Hydrochloride: Top Interactions at a Glance

The Ozanimod Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 159 interacting ingredients — plus 1,293 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ozanimod Hydrochloride Combinations Today

The Ozanimod Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Cowhage + Ozanimod Hydrochloridei

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Likely Yohimbe + Ozanimod Hydrochloridei

Concomitant use of MAOIs with yohimbe can result in additive effects.

Read the full interaction Major Likelihood Likely Brewer's Yeast + Ozanimod Hydrochloridei

Theoretically, taking brewer's yeast with MAOIs might increase the risk of hypertension.

Read the full interaction Moderate Likelihood Possible Phenylalanine + Ozanimod Hydrochloridei

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Read the full interaction Major Likelihood Probable Bitter Orange + Ozanimod Hydrochloridei

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to...

Read the full interaction Major Likelihood Likely Soy + Ozanimod Hydrochloridei

Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.

Read the full interaction
The complete list

Every Supplement Checked Against Ozanimod Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 159 with a Ozanimod Hydrochloride interaction on file and 1,293 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ozanimod Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cowhage with Ozanimod Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Cowhage + Ozanimod Hydrochloride answer

Can you take Yohimbe with Ozanimod Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of MAOIs with yohimbe can result in additive effects.

Full Yohimbe + Ozanimod Hydrochloride answer

Can you take Brewer's Yeast with Ozanimod Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking brewer's yeast with MAOIs might increase the risk of hypertension.

Full Brewer's Yeast + Ozanimod Hydrochloride answer

Can you take Phenylalanine with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.

Full Phenylalanine + Ozanimod Hydrochloride answer

Can you take Bitter Orange with Ozanimod Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, pot...

Full Bitter Orange + Ozanimod Hydrochloride answer

Can you take Black Cohosh with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Ozanimod Hydrochloride answer

Can you take Black Hoof Mushroom with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might reduce the effects of immunosuppressant medications.

Full Black Hoof Mushroom + Ozanimod Hydrochloride answer

Can you take Black Seed with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black seed might interfere with immunosuppressive therapy.

Full Black Seed + Ozanimod Hydrochloride answer

Can you take Black Tea with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Full Black Tea + Ozanimod Hydrochloride answer

Can you take Blood Irradiation Therapy with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that blood irradiation therapy may stimulate immune function in some patients.

Full Blood Irradiation Therapy + Ozanimod Hydrochloride answer

Can you take Blue-green Algae with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.

Full Blue-green Algae + Ozanimod Hydrochloride answer

Can you take Boldo with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Ozanimod Hydrochloride answer

Can you take Boswellia Serrata with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.

Full Boswellia Serrata + Ozanimod Hydrochloride answer

Can you take Breadfruit with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Breadfruit might increase the levels of drugs metabolized by cytochrome P450 2C8 (CYP2C8) enzymes.

Full Breadfruit + Ozanimod Hydrochloride answer

Can you take Buchu with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Ozanimod Hydrochloride answer

Can you take Bupleurum with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might decrease the effects of immunosuppressants.

Full Bupleurum + Ozanimod Hydrochloride answer

Can you take Caffeine with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of a hypertensive crisis.

Full Caffeine + Ozanimod Hydrochloride answer

Can you take Calamus with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, calamus might potentiate the effects and adverse effects of MAOIs.

Full Calamus + Ozanimod Hydrochloride answer

Can you take Camphor with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Ozanimod Hydrochloride answer

Can you take Cannabidiol (cbd) with Ozanimod Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might increase levels of drugs metabolized by CYP2C8.

Full Cannabidiol (cbd) + Ozanimod Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ozanimod Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ozanimod Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ozanimod Hydrochloride sits in 6 interaction categories. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Ozanimod Hydrochloride through this category.

Monoamine Oxidase Inhibitors (Maois) 42 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

42 of the supplement ingredients on this page reach Ozanimod Hydrochloride through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Ozanimod Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ozanimod Hydrochloride through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Ozanimod Hydrochloride through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Ozanimod Hydrochloride through this category.

About Ozanimod Hydrochloride

Ozanimod is an oral immunomodulating medicine used to treat relapsing forms of multiple sclerosis and moderately to severely active ulcerative colitis in adults.

Generic name: Ozanimod Hydrochloride  ·  Brand name: Zeposia.

See the full Ozanimod drug information
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Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ozanimod Hydrochloride.

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Pharmacist Counseling Corner

Ozanimod Hydrochloride & Supplements: Common Questions

What supplements interact with Ozanimod Hydrochloride?
In our interaction database, 159 supplement and herbal ingredients have an interaction with Ozanimod Hydrochloride on file — 20 rated major, 127 moderate, and 12 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Brewer's Yeast, Fever Bark, Siberian Cocklebur.
Which Ozanimod Hydrochloride supplement interactions are the most serious?
Focus on the major group: Brewer's Yeast, Fever Bark, Siberian Cocklebur, Soy and Tyramine, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ozanimod Hydrochloride?
That depends entirely on which supplement. The honest answer for Ozanimod Hydrochloride is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zeposia have the same supplement interactions as Ozanimod Hydrochloride?
Yes — Zeposia all contain Ozanimod Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ozanimod Hydrochloride and my other medications?
This page covers Ozanimod Hydrochloride against supplements and herbal ingredients. Checking Ozanimod Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ozanimod drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 27, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.