Medication interaction hub

What Supplements Interact with Rabeprazole Sodium?

Rabeprazole Sodium brand names: Aciphex, Aciphex Sprinkle. Every interaction below applies to the brands too.

169 Interactions 3 Major 116 Moderate 50 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Rabeprazole Sodium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Rabeprazole Sodium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Three entries on this rabeprazole (Aciphex) list call for real vigilance before you read further: grapefruit, St. John's wort, and activated charcoal, all rated major. Rabeprazole is a proton pump inhibitor that shuts off stomach acid so reflux calms and ulcers heal, and the majors pull in opposite directions. Grapefruit can raise its blood levels, St. John's wort revs the enzymes that clear it, and charcoal can soak up a dose before it absorbs, letting acid trouble creep back.

Most of what remains is the same enzyme story at lower stakes, herbs sharing the liver pathways rabeprazole uses and nudging its level either way. About 20 can add to sun sensitivity, and a few fibers and charcoals can blunt absorption of any oral pill, so space those well apart from your dose. All told, the list runs 169 ingredients, splitting past the three majors into 116 moderate and 50 minor.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 116 Minor 50 No known interaction 1,283

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Rabeprazole Sodium: Top Interactions at a Glance

The Rabeprazole Sodium supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 169 interacting ingredients — plus 1,283 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Rabeprazole Sodium Combinations Today

The Rabeprazole Sodium + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Grapefruit + Rabeprazole Sodiumi

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Probable Melatonin + Rabeprazole Sodiumi

Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.

Read the full interaction Minor Likelihood Possible Quassia + Rabeprazole Sodiumi

Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of PPIs.

Read the full interaction Minor Likelihood Unlikely Milk Thistle + Rabeprazole Sodiumi

It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Read the full interaction Major Likelihood Probable Activated Charcoal + Rabeprazole Sodiumi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable St. John's Wort + Rabeprazole Sodiumi

St.

Read the full interaction
The complete list

Every Supplement Checked Against Rabeprazole Sodium

All 1,452 ingredients in our database, ranked by severity — 169 with a Rabeprazole Sodium interaction on file and 1,283 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Rabeprazole Sodium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grapefruit with Rabeprazole Sodium?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Rabeprazole Sodium answer

Can you take Melatonin with Rabeprazole Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.

Full Melatonin + Rabeprazole Sodium answer

Can you take Quassia with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of PPIs.

Full Quassia + Rabeprazole Sodium answer

Can you take Milk Thistle with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Rabeprazole Sodium answer

Can you take Calumba with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calumba might decrease the effectiveness of H2-blockers.

Full Calumba + Rabeprazole Sodium answer

Can you take Carob with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Rabeprazole Sodium answer

Can you take Cascara Sagrada with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.

Full Cascara Sagrada + Rabeprazole Sodium answer

Can you take Celery with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.

Full Celery + Rabeprazole Sodium answer

Can you take Cinchona with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking cinchona might decrease the effectiveness of PPIs.

Full Cinchona + Rabeprazole Sodium answer

Can you take Eurycoma Longifolia with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.

Full Eurycoma Longifolia + Rabeprazole Sodium answer

Can you take Fucus Vesiculosus with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Rabeprazole Sodium answer

Can you take Hemp with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.

Full Hemp + Rabeprazole Sodium answer

Can you take Hercules Club with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hercules club may decrease the clinical effects of PPIs.

Full Hercules Club + Rabeprazole Sodium answer

Can you take Hibiscus Sabdariffa with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP2C19 substrates.

Full Hibiscus Sabdariffa + Rabeprazole Sodium answer

Can you take Honey with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Full Honey + Rabeprazole Sodium answer

Can you take Hops with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Rabeprazole Sodium answer

Can you take Karaya Gum with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Rabeprazole Sodium answer

Can you take Marshmallow with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Rabeprazole Sodium answer

Can you take Northern Prickly Ash with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, northern prickly ash might decrease the effectiveness of PPIs.

Full Northern Prickly Ash + Rabeprazole Sodium answer

Can you take Passion Flower with Rabeprazole Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Rabeprazole Sodium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Rabeprazole Sodium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Rabeprazole Sodium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Rabeprazole Sodium sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Rabeprazole Sodium through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Rabeprazole Sodium through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Rabeprazole Sodium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Rabeprazole Sodium through this category.

Proton Pump Inhibitors (Ppis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Rabeprazole Sodium through this category.

About Rabeprazole Sodium

Rabeprazole is a proton-pump inhibitor used to treat acid reflux, stomach ulcers, and conditions involving excess stomach acid.

Generic name: Rabeprazole Sodium  ·  Brand names: Aciphex, Aciphex Sprinkle.

See the full Rabeprazole drug information

Related: does Rabeprazole Sodium deplete any nutrients?

Rabeprazole Sodium has 18 reported nutrient associations in the research literature — see the Rabeprazole Sodium nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Rabeprazole Sodium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Rabeprazole Sodium.

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Pharmacist Counseling Corner

Rabeprazole Sodium & Supplements: Common Questions

What supplements interact with Rabeprazole Sodium?
More than you might expect — 169 in total, though they are far from equal: 3 are rated major, 116 moderate, and 50 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Rabeprazole Sodium supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Rabeprazole Sodium?
Usually yes — most people on Rabeprazole Sodium can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Aciphex have the same supplement interactions as Rabeprazole Sodium?
Yes — Aciphex, Aciphex Sprinkle all contain Rabeprazole Sodium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Rabeprazole Sodium deplete any vitamins or nutrients?
It might — Rabeprazole Sodium has 18 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Rabeprazole Sodium nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Rabeprazole Sodium and my other medications?
This page covers Rabeprazole Sodium against supplements and herbal ingredients. Checking Rabeprazole Sodium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Rabeprazole drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.