Medication interaction hub

What Supplements Interact with Urea?

Urea brand name: Ureaphil. Every interaction below applies to the brands too.

200 Interactions 7 Major 169 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated September 27, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Urea? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Urea against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Urea (Ureaphil) is an osmotic diuretic, a drug that pulls fluid out of the body to relieve pressure inside the skull or the eye. Because it works by shifting fluid and blood pressure, this is a list to read with genuine care. Most of the interactions either add to or work against its effect on blood pressure, or compound the fluid and potassium shifts a diuretic already causes, and a few, lithium supplements and yellow dock among them, carry major ratings worth understanding first.

The sharpest risks cluster around the diuretic side. Yellow dock can deepen potassium loss, oleander turns more toxic when potassium runs low, and lithium can build up when its excretion slows. A smaller group, activated charcoal especially, can bind medicines taken by mouth, so keep those spaced well apart from oral doses. For scale, the other 193 entries split into 169 moderate and 24 minor.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 169 Minor 24 No known interaction 1,252

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Urea: Top Interactions at a Glance

The Urea supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 200 interacting ingredients — plus 1,252 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Urea Combinations Today

The Urea + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Asparagus Racemosus + Ureai

Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Read the full interaction Moderate Likelihood Possible Apple Cider Vinegar + Ureai

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Probable Eicosapentaenoic Acid (epa) + Ureai

Theoretically, taking EPA with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Black Seed + Ureai

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Hedge Mustard + Ureai

Theoretically, taking hedge mustard with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Read the full interaction Moderate Likelihood Possible Pleurisy Root + Ureai

Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion...

Read the full interaction
The complete list

Every Supplement Checked Against Urea

All 1,452 ingredients in our database, ranked by severity — 200 with a Urea interaction on file and 1,252 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Urea?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Asparagus Racemosus with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Full Asparagus Racemosus + Urea answer

Can you take Apple Cider Vinegar with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.

Full Apple Cider Vinegar + Urea answer

Can you take Eicosapentaenoic Acid (epa) with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking EPA with antihypertensive drugs might increase the risk of hypotension.

Full Eicosapentaenoic Acid (epa) + Urea answer

Can you take Black Seed with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Urea answer

Can you take Hedge Mustard with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hedge mustard with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Full Hedge Mustard + Urea answer

Can you take Oolong Tea with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.

Full Oolong Tea + Urea answer

Can you take Oregon Grape with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.

Full Oregon Grape + Urea answer

Can you take Parsley with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.

Full Parsley + Urea answer

Can you take Pheasant's Eye with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pheasant's eye with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Full Pheasant's Eye + Urea answer

Can you take Phellodendron with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might have additive effects with antihypertensive drugs.

Full Phellodendron + Urea answer

Can you take Pleurisy Root with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to...

Full Pleurisy Root + Urea answer

Can you take Pomegranate with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Full Pomegranate + Urea answer

Can you take Quassia with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of quassia might compound diuretic-induced potassium loss.

Full Quassia + Urea answer

Can you take Quercetin with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.

Full Quercetin + Urea answer

Can you take Rauvolfia Vomitoria with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Rauvolfia vomitoria might increase the risk of hypotension.

Full Rauvolfia Vomitoria + Urea answer

Can you take Rehmannia with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.

Full Rehmannia + Urea answer

Can you take Reishi Mushroom with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Full Reishi Mushroom + Urea answer

Can you take Rhodiola with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Full Rhodiola + Urea answer

Can you take Rhubarb with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.

Full Rhubarb + Urea answer

Can you take Royal Jelly with Urea?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.

Full Royal Jelly + Urea answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Urea is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Urea, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Urea sits in 3 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Urea through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Urea through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Urea through this category.

Related: does Urea deplete any nutrients?

Urea has 7 reported nutrient associations in the research literature — see the Urea nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Urea

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Urea.

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Products that contain Urea-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Urea.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Urea & Supplements: Common Questions

What supplements interact with Urea?
In our interaction database, 200 supplement and herbal ingredients have an interaction with Urea on file — 7 rated major, 169 moderate, and 24 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Urea supplement interactions are the most serious?
Focus on the major group: American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Lithium, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Urea?
That depends entirely on which supplement. The honest answer for Urea is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Ureaphil have the same supplement interactions as Urea?
Yes — Ureaphil all contain Urea, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Urea deplete any vitamins or nutrients?
It might — Urea has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Urea nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Urea and my other medications?
This page covers Urea against supplements and herbal ingredients. Checking Urea against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 27, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.