Drug & supplement interaction

Danshen + Hethylphenidate HCl

Hethylphenidate HCl brand name: Hethylphenidate HCl.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Danshen and Hethylphenidate HCl in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Danshen and Hethylphenidate HCl

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hethylphenidate HCl and Danshen in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Danshen safety at a glance

Danshen overall Use caution May be used short-term by some adults, but it can affect blood clotting and quality varies between products.

Pregnancy Avoid Not enough safety information; best avoided during pregnancy.

Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hethylphenidate HCl and Danshen? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Hethylphenidate HCl

Interactions in our licensed database are recorded against drug classes, not just single drug names. Hethylphenidate HCl is filed under 3 classifications — amphetamines, stimulant drugs, oral drugs. Danshen has documented interactions with 16 drug classes — the most serious being anticoagulant/antiplatelet drugs (major), digoxin (lanoxin) (major) and amlodipine (norvasc) (moderate) — and none of Hethylphenidate HCl’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Danshen Does Interact With Other Medications

Danshen has 123 major, 936 moderate known drug interactions in our database — Hethylphenidate HCl isn’t one of them. If you take anything else, check it against the full list below.

Major 123 Moderate 936 No known interaction 1,771 (incl. Hethylphenidate HCl)

Taking anything else?

Check Another of Your Medications Against Danshen

Covers the 2,830 medications we’ve checked against Danshen. Pick one to open its full report.

What to actually watch for

What Danshen Itself Has Been Linked To

This is not an interaction — nothing below involves Hethylphenidate HCl. It is the side-effect record for Danshen on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Danshen, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

A low platelet count Worth acting on Additional detail
“Orally or intravenously, side effects of danshen preparations reported in clinical trials include thrombocytopenia; however, it is not known if this effect was due to danshen or other drugs.”

Danshen · Natural Medicines adverse-effect record, reported in thrombocytopenia.
1 source cited

15538. Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. PubMed
Drowsiness / Dizziness / Headache Additional detail
“Orally or intravenously, in clinical trials, side effects of danshen preparations include drowsiness, dizziness, or headache; however, it is not known if these effects were due to danshen or other drugs.”

Danshen · Natural Medicines adverse-effect record, reported in cluster headache.
2 sources cited

15538. Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. PubMed

109370. Ma XJ, Duan WH, Zhang Y, et al. Combination of activating blood circulation and detoxifying Chinese medicines played an anti-inflammatory role in unstable angina patients after percutaneous coronary intervention: A multicenter, open-labeled, randomized co
Reduced appetite / Stomach upset Additional detail

“Orally, danshen seems to be well tolerated. There is limited reliable information available about the adverse effects of danshen when used intravenously.

Most Common Adverse Effects:

Orally or intravenously: Upset stomach, pruritus, and reduced appetite.”

Danshen · Natural Medicines adverse-effect record, reported in pruritus.
Itching Additional detail
“Orally or intravenously, danshen can cause pruritus (12,96440).”

Danshen · Natural Medicines adverse-effect record, reported in pruritus.
2 sources cited

12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

96440. Yin QS, Chen L, Mi RH, Ai H, Yin JJ, Liu XJ, Wei XD. Efficacy and safety of danshen compound tablets in preventing thalidomide-associated thromboembolism in patients with multiple myeloma: a multicenter retrospective study. Med Sci Monit. 2016 Oct 20;22:3 PubMed

Everything above comes from the Natural Medicines adverse-effect record for Danshen — expand a row for the licensed statement it rests on. We haven’t matched Hethylphenidate HCl to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Hethylphenidate HCl.

Everything else you take

See Every Supplement That Interacts With Hethylphenidate HCl

This page covers Danshen only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hethylphenidate HCl page lists 65 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 47 moderate · 13 minor.

From our pharmacist’s overview on the Hethylphenidate HCl page

“Hethylphenidate HCl is a stimulant medication, which is exactly why this list deserves genuine care rather than a quick skim. Of the 65 supplement and herbal ingredients with an interaction on file, 44 pile more stimulant effect on top of the drug, raising blood pressure, heart rate, and cardiovascular risk.”

Reviewed by 2 · Jul 18, 2026

Open the Hethylphenidate HCl interaction page

One more smart check

Taking Danshen as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Danshen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Danshen. Even though Danshen itself has no known interaction with Hethylphenidate HCl, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Danshen and Hethylphenidate HCl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Danshen

Top half

#599 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Hethylphenidate HCl

Top 5%

#95 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Danshen reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Danshen and Hethylphenidate HCl records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Danshen

What is Danshen?

Heart and circulation support
Angina (chest pain)
High blood pressure
Anxiety and stress
Liver health

Danshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems. Some early research is promising, but the evidence is not strong enough to confirm it works for any condition, and it may affect blood clotting. Talk to a pharmacist or doctor before using it, especially if you take other medicines or have a health condition.

Salvia miltiorrhiza · Lamiaceae · Root · Capsules, tablets, dried root, teas, tinctures, and injectable forms used in some Asian countries

An interaction check asks whether these two react with each other — it does not ask whether Danshen is a good idea for someone in your situation. Here is what our Danshen record says about it on its own.

Danshen: dosing

There is no well-established standard dose of Danshen for any condition. Studies have used different forms, strengths, and preparations, which makes it hard to recommend a single dose.If you choose to use a Danshen product, follow the directions on the product label and do not take more than recommended.

From our Danshen monograph — the full record covers uses, side effects and every documented interaction.

Read the full Danshen monograph & all interactions

Keep checking

Other Drugs & Danshen

Browse every other medication we’ve checked against Danshen — both the ones with a known interaction and the ones without. Select any drug for the full detail.

123Major

936Moderate

0Minor

1,770No known interaction

123 Major 936 Moderate 1,770 No interaction

Major

123 interactions

Showing 60 of 123 major interactions — see all 123 on the Danshen page.

Moderate

936 interactions

Showing 60 of 936 moderate interactions — see all 936 on the Danshen page.

No interaction 1,770 drugs checked — show the list

We also checked Danshen against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,770 medications checked with no known interaction — see the full Danshen list.

See the full Danshen interactions page

See every supplement checked against Hethylphenidate HCl, ranked by severity

Evidence & sources

Danshen References

The 28 references that drive our Danshen monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Yu CM, Chan JC, Sanderson JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337-9. PubMed
Tam LS, et al. Warfarin interacions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust N Z J Med 1995;25:258.
Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 2001;35:501-4. DOI
Chan TY. Drug interactions as a cause of overanticoagulation and bleedings in Chinese patients receiving warfarin. Int J Clin Pharmacol Ther 1998;36:403-5.
Izzat MB, Yim APC, El-Zufari MH. A taste of Chinese medicine! Ann Thorac Surg 1998;66:941-2. PubMed
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
Wahed A, Dasgupta A. Positive and negative in vitro interference of Chinese medicine dan shen in serum digoxin measurement. Elimination of interference by monitoring free digoxin concentration. Am J Clin Pathol 2001;116:403-408. PubMed
Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. PubMed
Qiu F, Wang G, Zhang R, Sun J, et al. Effect of danshen extract on the activity of CYP3A4 in healthy volunteers. Br J Clin Pharmacol 2010;69:656-62. PubMed
Li CP, Yung KH, and Chiu KW. Hypotensive action of Salvia miltiorrhiza cell culture extract. American Journal of Chinese Medicine 1990;18(3-4):157-166.
Chu Y, Zhang L, Wang XY, Guo JH, Guo ZX, Ma XH. The effect of Compound Danshen Dripping Pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Ethnopharmacol. 2011 Oct 11;137(3):1457-61. PubMed
Ma S, Ju W, Dai G, Zhao W, Cheng X, Fang Z, Tan H, Wang X. Synergistic effects of clopidogrel and fufang danshen dripping pills by modulation of the metabolism target and pharmacokinetics. Evid Based Complement Alternat Med. 2014;2014:789142. PubMed
Qiu F, Jiang J, Ma Y, Wang G, Gao C, Zhang X, Zhang L, Liu S, He M, Zhu L, Ye Y, Li Q, Miao P. Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers. Evid Based Complement Alternat Me PubMed
Qiu F, Zeng J, Liu S, He M, Zhu L, Ye Y, Miao P, Shen S, Jiang J. Effects of danshen ethanol extract on the pharmacokinetics of fexofenadine in healthy volunteers. Evid Based Complement Alternat Med. 2014;2014:473213. PubMed
Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine. 2010 Sep;17(11):868-75. PubMed
Wang X, Yeung JH. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine. 2012 Feb 15;19(3-4):348-54. PubMed
Wen JH, Xiong YQ. The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. Eur J Drug Metab Pharmacokinet. 2011 Dec;36(4):205-11. PubMed
Zhang Z, Ge B, Zhou L, Lam TN, Zuo Z. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. J Ethnopharmacol. 2014 Jul 3;154(3):672-86. PubMed
Zhou X, Chan K, Yeung JH. Herb-drug interactions with Danshen (Salvia miltiorrhiza): a review on the role of cytochrome P450 enzymes. Drug Metabol Drug Interact. 2012 Mar 2;27(1):9-18.
Zhou L, Wang S, Zhang Z, Lau BS, Fung KP, Leung PC, Zuo Z. Pharmacokinetic and pharmacodynamic interaction of Danshen-Gegen extract with warfarin and aspirin. J Ethnopharmacol. 2012 Sep 28;143(2):648-55. PubMed
Lv C, Liu C, Yao Z, et al. The clinical pharmacokinetics and pharmacodynamics of warfarin when combined with compound danshen: a case study for combined treatment of coronary heart diseases with atrial fibrillation. Front Pharmacol. 2017 Nov 21;8:826. PubMed
Yin QS, Chen L, Mi RH, Ai H, Yin JJ, Liu XJ, Wei XD. Efficacy and safety of danshen compound tablets in preventing thalidomide-associated thromboembolism in patients with multiple myeloma: a multicenter retrospective study. Med Sci Monit. 2016 Oct 20;22:3 PubMed
Zhang H, Han X, Li Y, Li H, Guo X. Effects of danshen tablets on pharmacokinetics of amlodipine in rats. Pharm Biol. 2019;57(1):306-309. PubMed
Zhang Y, Yang M, Ho NJ, et al. Is it safe to take Radix Salvia Miltiorrhiza - Radix Pueraria Lobate product with warfarin and aspirin? A pilot study in healthy human subjects. J Ethnopharmacol. 2020 Nov 15;262:113151. PubMed
Ma XJ, Duan WH, Zhang Y, et al. Combination of activating blood circulation and detoxifying Chinese medicines played an anti-inflammatory role in unstable angina patients after percutaneous coronary intervention: A multicenter, open-labeled, randomized co
Liu J, Shi Y, Wu C, et al. Comparison of sweated and non-sweated ethanol extracts of Salvia miltiorrhiza Bge. (Danshen) effects on human and rat hepatic UDP-glucuronosyltransferase and preclinic herb-drug interaction potential evaluation. Curr Drug Metab
Zheng D, Zhang W, Hou M, et al. Evaluation of herb-drug interactions between compound Danshen dripping pills and clopidogrel based on the pharmacokinetics and pharmacodynamics in rats. Biomed Chromatogr. 2023;37(9):e5684. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Danshen and Hethylphenidate HCl Together: Common Questions

Is it safe to take Danshen with Hethylphenidate HCl?

We do not list a known interaction between Danshen and Hethylphenidate HCl. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Danshen and Hethylphenidate HCl combination checked?

Interactions in our licensed database are recorded against drug classes. Hethylphenidate HCl is filed under 3 classifications, and Danshen has documented interactions with 16 drug classes — none of Hethylphenidate HCl's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Danshen interact with any other medications?

Yes. Danshen has 1,059 documented drug interactions in our database — Hethylphenidate HCl is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Hethylphenidate HCl interact with any supplements?

Yes. Hethylphenidate HCl has documented interactions with 65 supplements in our database — Danshen is not one of them. The Hethylphenidate HCl interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Danshen monograph Uses, safety profile, and every drug interaction in one place Hethylphenidate HCl supplement interactions Every supplement checked against Hethylphenidate HCl, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 28 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.