Medication interaction hub

What Supplements Interact with Methyclothiazide, Pargyline?

Methyclothiazide, Pargyline brand name: Eutron. Every interaction below applies to the brands too.

227 Interactions 10 Major 192 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Methyclothiazide, Pargyline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Methyclothiazide, Pargyline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Few blood pressure medicines demand as much supplement caution as Eutron, which pairs methyclothiazide, a water pill, with pargyline, an older MAO inhibitor. Ten of the 227 ingredients on file rate major; learn those first. Most of the list either deepens the blood pressure drop (119 ingredients) or adds to the diuretic effect, draining more potassium or fluid. Tyramine stands out because pargyline blocks the enzyme that breaks it down, so it can push blood pressure the wrong way.

Activated charcoal can soak up the medication itself, so keep any charcoal product far from your dose. Twenty more can heighten sun sensitivity, which thiazides already cause, and the 192 moderate plus 25 minor entries are mostly gentler versions of the same additive effects. The one I would not shrug off is calcium. Dolomite and similar sources can push blood calcium dangerously high, since thiazides keep it from leaving the body.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 192 Minor 25 No known interaction 1,225

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Methyclothiazide, Pargyline: Top Interactions at a Glance

The Methyclothiazide, Pargyline supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 227 interacting ingredients — plus 1,225 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Methyclothiazide, Pargyline Combinations Today

The Methyclothiazide, Pargyline + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Goldenseal + Methyclothiazide, Pargylinei

Theoretically, goldenseal might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Cola Nut + Methyclothiazide, Pargylinei

Theoretically, using cola nut with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Possible Gentian + Methyclothiazide, Pargylinei

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Minor Likelihood Possible Birch + Methyclothiazide, Pargylinei

Theoretically, birch might interfere with diuretic therapy.

Read the full interaction Major Likelihood Likely American Hellebore + Methyclothiazide, Pargylinei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Methyclothiazide, Pargylinei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction
The complete list

Every Supplement Checked Against Methyclothiazide, Pargyline

All 1,452 ingredients in our database, ranked by severity — 227 with a Methyclothiazide, Pargyline interaction on file and 1,225 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Methyclothiazide, Pargyline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Goldenseal with Methyclothiazide, Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the risk of hypotension when taken with antihypertensive drugs.

Full Goldenseal + Methyclothiazide, Pargyline answer

Can you take Cola Nut with Methyclothiazide, Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using cola nut with diuretic drugs might increase the risk of hypokalemia.

Full Cola Nut + Methyclothiazide, Pargyline answer

Can you take Gentian with Methyclothiazide, Pargyline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.

Full Gentian + Methyclothiazide, Pargyline answer

Can you take Birch with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, birch might interfere with diuretic therapy.

Full Birch + Methyclothiazide, Pargyline answer

Can you take Humann Superbeets Heart Chews with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews).

Full Humann Superbeets Heart Chews + Methyclothiazide, Pargyline answer

Can you take Juniper with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Full Juniper + Methyclothiazide, Pargyline answer

Can you take Karaya Gum with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Methyclothiazide, Pargyline answer

Can you take Marshmallow with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Methyclothiazide, Pargyline answer

Can you take N-methyltyramine with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In animal research, N-methyltyramine increased blood pressure.

Full N-methyltyramine + Methyclothiazide, Pargyline answer

Can you take Nicotinamide Riboside with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.

Full Nicotinamide Riboside + Methyclothiazide, Pargyline answer

Can you take Pu-erh Tea with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, using pu-erh tea with diuretic drugs might increase the risk of hypokalemia.

Full Pu-erh Tea + Methyclothiazide, Pargyline answer

Can you take Puravive with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains quercetin, which has been found to slightly reduce blood pressure in individuals with mild hypertension (https://pubmed.nc...

Full Puravive + Methyclothiazide, Pargyline answer

Can you take Stevia with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.

Full Stevia + Methyclothiazide, Pargyline answer

Can you take Xanthan Gum with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Methyclothiazide, Pargyline answer

Can you take Asian Water Plantain with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Methyclothiazide, Pargyline answer

Can you take Equol with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, equol might cause additive diuretic effects when used with diuretic drugs.

Full Equol + Methyclothiazide, Pargyline answer

Can you take Hemp with Methyclothiazide, Pargyline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.

Full Hemp + Methyclothiazide, Pargyline answer

Can you take American Hellebore with Methyclothiazide, Pargyline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Full American Hellebore + Methyclothiazide, Pargyline answer

Can you take Siberian Cocklebur with Methyclothiazide, Pargyline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the kidney.

Full Siberian Cocklebur + Methyclothiazide, Pargyline answer

Can you take Tyramine with Methyclothiazide, Pargyline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Full Tyramine + Methyclothiazide, Pargyline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Methyclothiazide, Pargyline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Methyclothiazide, Pargyline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Methyclothiazide, Pargyline sits in 6 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Methyclothiazide, Pargyline through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Methyclothiazide, Pargyline through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Methyclothiazide, Pargyline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Methyclothiazide, Pargyline through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Methyclothiazide, Pargyline through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Methyclothiazide, Pargyline through this category.

Related: does Methyclothiazide, Pargyline deplete any nutrients?

Methyclothiazide, Pargyline has 9 reported nutrient associations in the research literature — see the Methyclothiazide, Pargyline nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Methyclothiazide, Pargyline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Methyclothiazide, Pargyline.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Methyclothiazide, Pargyline & Supplements: Common Questions

What supplements interact with Methyclothiazide, Pargyline?
In our interaction database, 227 supplement and herbal ingredients have an interaction with Methyclothiazide, Pargyline on file — 10 rated major, 192 moderate, and 25 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Methyclothiazide, Pargyline supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Methyclothiazide, Pargyline?
That depends entirely on which supplement. The honest answer for Methyclothiazide, Pargyline is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Eutron have the same supplement interactions as Methyclothiazide, Pargyline?
Yes — Eutron all contain Methyclothiazide, Pargyline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Methyclothiazide, Pargyline deplete any vitamins or nutrients?
It might — Methyclothiazide, Pargyline has 9 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Methyclothiazide, Pargyline nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Methyclothiazide, Pargyline and my other medications?
This page covers Methyclothiazide, Pargyline against supplements and herbal ingredients. Checking Methyclothiazide, Pargyline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.