Medication interaction hub

What Supplements Interact with Segesterone Acetate, Ethinyl Estradiol?

Segesterone Acetate, Ethinyl Estradiol brand name: Annovera. Every interaction below applies to the brands too.

229 Interactions 5 Major 193 Moderate 31 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Segesterone Acetate, Ethinyl Estradiol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Segesterone Acetate, Ethinyl Estradiol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

St. John's wort is the interaction I would explain first to anyone using Annovera (segesterone acetate with ethinyl estradiol, a vaginal ring for birth control). It speeds the liver's clearance of these hormones, which can drop their levels enough to put the ring's contraceptive protection at risk. It is one of five major-rated entries among the 229 supplements and herbs on file here, and those five make this a page worth reading closely rather than skimming.

Grapefruit pulls the other way, raising hormone levels and side effect risk, while heavy drinking adds to a cluster of liver-stressing ingredients. Many of the 193 moderate entries involve estrogen slowing how the body clears caffeine, so caffeinated drinks and stimulant supplements may hit harder and linger longer than expected. A few herbs act on estrogen receptors themselves. The 31 minor entries carry less weight, but read the full entry on any product you take often.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 193 Minor 31 No known interaction 1,223

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Segesterone Acetate, Ethinyl Estradiol: Top Interactions at a Glance

The most significant Segesterone Acetate, Ethinyl Estradiol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 229 interacting ingredients — plus 1,223 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Segesterone Acetate, Ethinyl Estradiol + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Segesterone Acetate, Ethinyl Estradioli

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Segesterone Acetate, Ethinyl Estradioli

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Beer + Segesterone Acetate, Ethinyl Estradioli

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable St. John's Wort + Segesterone Acetate, Ethinyl Estradioli

St.

Read the full interaction Major Likelihood Probable Wine + Segesterone Acetate, Ethinyl Estradioli

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Segesterone Acetate, Ethinyl Estradiol

All 1,452 ingredients in our database, ranked by severity — 229 with a Segesterone Acetate, Ethinyl Estradiol interaction on file and 1,223 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Segesterone Acetate, Ethinyl Estradiol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bacopa with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.

Full Bacopa + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Baikal Skullcap with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.

Full Baikal Skullcap + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Beet with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Berberine with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Beta-methylphenethylamine (bmpea) with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Bishop's Weed with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Bitter Melon with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Bitter Orange with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Black Cohosh with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Black Hoof Mushroom with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.

Full Black Hoof Mushroom + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Black Pepper with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Bog Labrador Tea with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Boldo with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Boswellia Serrata with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.

Full Boswellia Serrata + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Bridelia with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animals, Bridelia ferruginea extract has estrogenic effects, although the magnitude of these effects is less than that of ethinylestradio...

Full Bridelia + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Broccoli with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.

Full Broccoli + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Brussels Sprout with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Brussels sprout can induce cytochrome P450 1A2 (CYP1A2) activity.

Full Brussels Sprout + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Buchu with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Bulbine Natalensis with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP1A2 substrates.

Full Bulbine Natalensis + Segesterone Acetate, Ethinyl Estradiol answer

Can you take Cabbage with Segesterone Acetate, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.

Full Cabbage + Segesterone Acetate, Ethinyl Estradiol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Segesterone Acetate, Ethinyl Estradiol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Segesterone Acetate, Ethinyl Estradiol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Segesterone Acetate, Ethinyl Estradiol sits in 13 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Segesterone Acetate, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Segesterone Acetate, Ethinyl Estradiol through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Segesterone Acetate, Ethinyl Estradiol through this category.

Related: does Segesterone Acetate, Ethinyl Estradiol deplete any nutrients?

Segesterone Acetate, Ethinyl Estradiol has 7 reported nutrient associations in the research literature — see the Segesterone Acetate, Ethinyl Estradiol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Segesterone Acetate, Ethinyl Estradiol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Segesterone Acetate, Ethinyl Estradiol.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Segesterone Acetate, Ethinyl Estradiol & Supplements: Common Questions

What supplements interact with Segesterone Acetate, Ethinyl Estradiol?
Our database currently documents 229 ingredients with a known Segesterone Acetate, Ethinyl Estradiol interaction (5 major, 193 moderate, 31 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 229. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Beer.
Which Segesterone Acetate, Ethinyl Estradiol supplement interactions are the most serious?
The 5 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Beer, St. John's Wort and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Segesterone Acetate, Ethinyl Estradiol?
Plenty of supplements coexist fine with Segesterone Acetate, Ethinyl Estradiol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Annovera have the same supplement interactions as Segesterone Acetate, Ethinyl Estradiol?
Yes — Annovera all contain Segesterone Acetate, Ethinyl Estradiol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Segesterone Acetate, Ethinyl Estradiol deplete any vitamins or nutrients?
It might — Segesterone Acetate, Ethinyl Estradiol has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Segesterone Acetate, Ethinyl Estradiol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Segesterone Acetate, Ethinyl Estradiol and my other medications?
This page covers Segesterone Acetate, Ethinyl Estradiol against supplements and herbal ingredients. Checking Segesterone Acetate, Ethinyl Estradiol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.