Drug & supplement interaction

Danshen + Secukinumab

Secukinumab brand name: Cosentyx.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Danshen and Secukinumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Danshen and Secukinumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Secukinumab and Danshen in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Danshen safety at a glance

Danshen overall Use caution May be used short-term by some adults, but it can affect blood clotting and quality varies between products.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Secukinumab and Danshen? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Danshen Does Interact With Other Medications

Danshen has 123 major, 936 moderate known drug interactions in our database — Secukinumab isn’t one of them. If you take anything else, check it against the full list below.

Major 123 Moderate 936 No known interaction 1,771 (incl. Secukinumab)
Taking anything else?

Check Another of Your Medications Against Danshen

Covers the 2,830 medications we’ve checked against Danshen. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Danshen and Secukinumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset Additional detail

    Danshen

    “Orally, danshen seems to be well tolerated. There is limited reliable information available about the adverse effects of danshen when used intravenously.

    Most Common Adverse Effects:

    Orally or intravenously: Upset stomach, pruritus, and reduced appetite.”

    Danshen · Natural Medicines adverse-effect record, reported in pruritus.

    Secukinumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Secukinumab. Read the label on DailyMed ›

  • Headache Additional detail

    Danshen

    “Orally or intravenously, in clinical trials, side effects of danshen preparations include drowsiness, dizziness, or headache; however, it is not known if these effects were due to danshen or other drugs.”

    Danshen · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 15538. Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. PubMed
    2. 109370. Ma XJ, Duan WH, Zhang Y, et al. Combination of activating blood circulation and detoxifying Chinese medicines played an anti-inflammatory role in unstable angina patients after percutaneous coronary intervention: A multicenter, open-labeled, randomized co

    Secukinumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Secukinumab. Read the label on DailyMed ›

Reported for Danshen but not commonly for Secukinumab: reduced appetite, a low platelet count, drowsiness and dizziness.

Effects for Secukinumab come from the ADVERSE REACTIONS section of its FDA label; effects for Danshen come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 158,767 voluntary FDA FAERS reports for Secukinumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Secukinumab Is Prescribed For, and What Danshen Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Secukinumab is a prescription medicine with approved uses on its FDA label. Danshen is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Secukinumab is prescribed for: Cosentyx is used to treat several immune-related conditions. In adults and children 6 and older, it treats moderate to severe plaque psoriasis. In adults and children 2 and older, it treats active psoriatic arthritis. For ankylosing spondylitis (spinal inflammation), it is approved for adults and children 12 and older.

Read the rest of what Secukinumab is prescribed for

It also treats active non-radiographic axial spondyloarthritis (early spinal inflammation without visible joint damage on X-ray) in adults, and enthesitis-related arthritis (inflammation where tendons attach to bone) in children 4 and older. Moderate to severe hidradenitis suppurativa (a painful skin condition with recurring boils) is also an approved use for adults and children 12 and older. Cosentyx intravenous (IV) infusion is approved only for adults with psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. Subcutaneous (under-the-skin) injection covers the full range of approved uses for both adults and children.

Danshen has been studied for:

  • Psoriasis studied, not established Danshen has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Danshen for psoriasis

    Although there is interest in using oral danshen for psoriasis, there is insufficient reliable information about the clinical effects of danshen for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Secukinumab on your own; if you are taking Danshen for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Danshen as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Danshen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Danshen. Even though Danshen itself has no known interaction with Secukinumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Danshen and Secukinumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Danshen
Top half

#593 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Secukinumab
Steady interest

#2,704 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Danshen reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Danshen and Secukinumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Danshen

What is Danshen?

Danshen
  • Heart and circulation support
  • Angina (chest pain)
  • High blood pressure
  • Anxiety and stress
  • Liver health

Danshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems. Some early research is promising, but the evidence is not strong enough to confirm it works for any condition, and it may affect blood clotting. Talk to a pharmacist or doctor before using it, especially if you take other medicines or have a health condition.

Salvia miltiorrhiza · Lamiaceae · Root · Capsules, tablets, dried root, teas, tinctures, and injectable forms used in some Asian countries

An interaction check asks whether these two react with each other — it does not ask whether Danshen is a good idea for someone in your situation. Here is what our Danshen record says about it on its own.

Danshen: dosing

There is no well-established standard dose of Danshen for any condition. Studies have used different forms, strengths, and preparations, which makes it hard to recommend a single dose.If you choose to use a Danshen product, follow the directions on the product label and do not take more than recommended.

From our Danshen monograph — the full record covers uses, side effects and every documented interaction.

Read the full Danshen monograph & all interactions
Medication

About Secukinumab Injection

What Is Secukinumab Injection Used For?

Brand name: Cosentyx

Cosentyx is used to treat several immune-related conditions. In adults and children 6 and older, it treats moderate to severe plaque psoriasis. In adults and children 2 and older, it treats active psoriatic arthritis. For ankylosing spondylitis (spinal inflammation), it is approved for adults and children 12 and older. It also treats active non-radiographic axial spondyloarthritis (early spinal inflammation without visible joint damage on X-ray) in adults, and enthesitis-related arthritis (inflammation where tendons attach to bone) in children 4 and older. Moderate to severe hidradenitis suppurativa (a painful skin condition with recurring boils) is also an approved use for adults and children 12 and older.

Cosentyx intravenous (IV) infusion is approved only for adults with psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. Subcutaneous (under-the-skin) injection covers the full range of approved uses for both adults and children.

Most-Reported Side Effects for Secukinumab

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Psoriasis 22,826 reports
Arthralgia 14,911 reports
Fatigue 10,590 reports
Psoriatic arthropathy 10,208 reports
Malaise 9,466 reports
See full Secukinumab Injection drug information
Keep checking

Other Drugs & Danshen

Browse every other medication we’ve checked against Danshen — both the ones with a known interaction and the ones without. Select any drug for the full detail.

123Major
936Moderate
0Minor
1,770No known interaction
123 Major 936 Moderate 1,770 No interaction
Major

123 interactions

Showing 60 of 123 major interactions — see all 123 on the Danshen page.

Moderate

936 interactions

Showing 60 of 936 moderate interactions — see all 936 on the Danshen page.

No interaction 1,770 drugs checked — show the list

We also checked Danshen against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,770 medications checked with no known interaction — see the full Danshen list.

See the full Danshen interactions page
See every supplement checked against Secukinumab, ranked by severity
Evidence & sources

Danshen References

The 28 references that drive our Danshen monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Yu CM, Chan JC, Sanderson JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337-9. PubMed
  3. Tam LS, et al. Warfarin interacions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust N Z J Med 1995;25:258.
  4. Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 2001;35:501-4. DOI
  5. Chan TY. Drug interactions as a cause of overanticoagulation and bleedings in Chinese patients receiving warfarin. Int J Clin Pharmacol Ther 1998;36:403-5.
  6. Izzat MB, Yim APC, El-Zufari MH. A taste of Chinese medicine! Ann Thorac Surg 1998;66:941-2. PubMed
  7. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  8. Wahed A, Dasgupta A. Positive and negative in vitro interference of Chinese medicine dan shen in serum digoxin measurement. Elimination of interference by monitoring free digoxin concentration. Am J Clin Pathol 2001;116:403-408. PubMed
  9. Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. PubMed
  10. Qiu F, Wang G, Zhang R, Sun J, et al. Effect of danshen extract on the activity of CYP3A4 in healthy volunteers. Br J Clin Pharmacol 2010;69:656-62. PubMed
  11. Li CP, Yung KH, and Chiu KW. Hypotensive action of Salvia miltiorrhiza cell culture extract. American Journal of Chinese Medicine 1990;18(3-4):157-166.
  12. Chu Y, Zhang L, Wang XY, Guo JH, Guo ZX, Ma XH. The effect of Compound Danshen Dripping Pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Ethnopharmacol. 2011 Oct 11;137(3):1457-61. PubMed
  13. Ma S, Ju W, Dai G, Zhao W, Cheng X, Fang Z, Tan H, Wang X. Synergistic effects of clopidogrel and fufang danshen dripping pills by modulation of the metabolism target and pharmacokinetics. Evid Based Complement Alternat Med. 2014;2014:789142. PubMed
  14. Qiu F, Jiang J, Ma Y, Wang G, Gao C, Zhang X, Zhang L, Liu S, He M, Zhu L, Ye Y, Li Q, Miao P. Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers. Evid Based Complement Alternat Me PubMed
  15. Qiu F, Zeng J, Liu S, He M, Zhu L, Ye Y, Miao P, Shen S, Jiang J. Effects of danshen ethanol extract on the pharmacokinetics of fexofenadine in healthy volunteers. Evid Based Complement Alternat Med. 2014;2014:473213. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Danshen and Secukinumab Together: Common Questions

Is it safe to take Danshen with Secukinumab?
We do not list a known interaction between Danshen and Secukinumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Danshen and Secukinumab have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Danshen and Secukinumab used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Danshen in each. That is a conversation for your prescriber, especially if Secukinumab is being adjusted to a target.
Does Danshen interact with any other medications?
Yes. Danshen has 1,059 documented drug interactions in our database — Secukinumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Danshen monograph Uses, safety profile, and every drug interaction in one place Secukinumab Injection drug information The full plain-English guide to this medication Secukinumab supplement interactions Every supplement checked against Secukinumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 28 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.