Medication interaction hub

What Supplements Interact with Atenolol, Chlortalidone?

Atenolol, Chlortalidone brand names: AtenixCo, Totaretic, Tenoret 50. Every interaction below applies to the brands too.

229 Interactions 9 Major 197 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Atenolol, Chlortalidone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Atenolol, Chlortalidone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

229 supplements and herbal ingredients have interactions with Atenolol, Chlortalidone on file in the HelloPharmacist interaction database — 9 rated major, 197 moderate, and 23 minor. The most serious involve American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Dolomite.

Our assessment: with 9 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Atenolol, Chlortalidone.

Major 9 Moderate 197 Minor 23 No known interaction 1,223

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Atenolol, Chlortalidone: Top Interactions at a Glance

The Atenolol, Chlortalidone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 229 interacting ingredients — plus 1,223 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Atenolol, Chlortalidone Combinations Today

The Atenolol, Chlortalidone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Calcium + Atenolol, Chlortalidonei

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Read the full interaction Moderate Likelihood Probable Vitamin D + Atenolol, Chlortalidonei

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Atenolol, Chlortalidonei

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Fish Oil + Atenolol, Chlortalidonei

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Sodium + Atenolol, Chlortalidonei

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Vitamin B6 + Atenolol, Chlortalidonei

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Atenolol, Chlortalidone

All 1,452 ingredients in our database, ranked by severity — 229 with a Atenolol, Chlortalidone interaction on file and 1,223 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Atenolol, Chlortalidone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Full Calcium + Atenolol, Chlortalidone answer

Can you take Vitamin D with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Full Vitamin D + Atenolol, Chlortalidone answer

Can you take Coenzyme Q10 with Atenolol, Chlortalidone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Atenolol, Chlortalidone answer

Can you take Fish Oil with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Atenolol, Chlortalidone answer

Can you take Sodium with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Atenolol, Chlortalidone answer

Can you take Malic Acid with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.

Full Malic Acid + Atenolol, Chlortalidone answer

Can you take Manna with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, manna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Manna + Atenolol, Chlortalidone answer

Can you take Melatonin with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Full Melatonin + Atenolol, Chlortalidone answer

Can you take N-acetyl Cysteine (nac) with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.

Full N-acetyl Cysteine (nac) + Atenolol, Chlortalidone answer

Can you take Nattokinase with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.

Full Nattokinase + Atenolol, Chlortalidone answer

Can you take Niacin with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Atenolol, Chlortalidone answer

Can you take Noni with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.

Full Noni + Atenolol, Chlortalidone answer

Can you take Octopamine with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In humans, octopamine 450-600 mg daily increases blood pressure in hypotensive patients.

Full Octopamine + Atenolol, Chlortalidone answer

Can you take Oolong Tea with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.

Full Oolong Tea + Atenolol, Chlortalidone answer

Can you take Oregon Grape with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.

Full Oregon Grape + Atenolol, Chlortalidone answer

Can you take Parsley with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.

Full Parsley + Atenolol, Chlortalidone answer

Can you take Pheasant's Eye with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pheasant's eye with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Full Pheasant's Eye + Atenolol, Chlortalidone answer

Can you take Phellodendron with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might have additive effects with antihypertensive drugs.

Full Phellodendron + Atenolol, Chlortalidone answer

Can you take Pleurisy Root with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to...

Full Pleurisy Root + Atenolol, Chlortalidone answer

Can you take Pomegranate with Atenolol, Chlortalidone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Full Pomegranate + Atenolol, Chlortalidone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Atenolol, Chlortalidone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Atenolol, Chlortalidone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Atenolol, Chlortalidone sits in 8 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Atenolol, Chlortalidone through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Atenolol, Chlortalidone through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Atenolol, Chlortalidone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Atenolol, Chlortalidone through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Atenolol, Chlortalidone through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Atenolol, Chlortalidone through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Atenolol, Chlortalidone through this category.

Atenolol (Tenormin) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Atenolol, Chlortalidone through this category.

Related: does Atenolol, Chlortalidone deplete any nutrients?

Atenolol, Chlortalidone has 24 reported nutrient associations in the research literature — see the Atenolol, Chlortalidone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Atenolol, Chlortalidone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Atenolol, Chlortalidone.

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Products that contain Atenolol, Chlortalidone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Atenolol, Chlortalidone.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Atenolol, Chlortalidone & Supplements: Common Questions

What supplements interact with Atenolol, Chlortalidone?
In our interaction database, 229 supplement and herbal ingredients have an interaction with Atenolol, Chlortalidone on file — 9 rated major, 197 moderate, and 23 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Atenolol, Chlortalidone supplement interactions are the most serious?
The 9 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Dolomite — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Atenolol, Chlortalidone?
That depends entirely on which supplement. The honest answer for Atenolol, Chlortalidone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like AtenixCo have the same supplement interactions as Atenolol, Chlortalidone?
Yes — AtenixCo, Totaretic, Tenoret 50 all contain Atenolol, Chlortalidone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Atenolol, Chlortalidone deplete any vitamins or nutrients?
It might — Atenolol, Chlortalidone has 24 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Atenolol, Chlortalidone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Atenolol, Chlortalidone and my other medications?
This page covers Atenolol, Chlortalidone against supplements and herbal ingredients. Checking Atenolol, Chlortalidone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.