Danshen - Hydralazine, Hydrochlorothiazide, Reserpine Interaction
Herbal: Danshen
Also Known As: Salvia bowleyana, Ch'ih Shen, Chinese Red Sage, Chinese Sage, Chinese Salvia, Dan Shen, Dan-Shen, Huang Ken, Racine de Salvia, Red Root Sage, Red Rooted Sage, Red Sage, Salvia Przewalskii Mandarinorum, Salvia Root, Shu-Wei Ts'ao, Tan Seng, Tan-Shen, Tzu Tan-Ken
Drug: Hydralazine, Hydrochlorothiazide, Reserpine
Brand names:
Ser-Ap-Es, Unipres, Uniserp
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Hydralazine, Hydrochlorothiazide, Reserpine is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that danshen can produce dose-dependent hypotensive effects. Furthermore, concomitant use with captopril appears to potentiate this effect.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Li CP, Yung KH, and Chiu KW. Hypotensive action of Salvia miltiorrhiza cell culture extract. American Journal of Chinese Medicine 1990;18(3-4):157-166.
Danshen Overview
Danshen, also known as Salvia miltiorrhiza, is a herb native to China and other parts of Asia. It is a member of the mint family and has been used for centuries in traditional Chinese medicine based on its purported anti-inflammatory and blood-thinning properties. It has historically been used to treat cardiovascular diseases, such as angina, and improve circulation. It has also been used to treat anxiety and stress, as it is thought to have calming and relaxing effects. The root of Danshen is what is utilized in dietary supplements.
Danshen - More Interactions
Danshen interacts with 1031 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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