Herb & supplement monograph

Inositol Nicotinate Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Inositol Nicotinate interacts with medications. The heart of this page is the interaction list — every drug Inositol Nicotinate is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Inositol Nicotinate is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Inositol Nicotinate Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Inositol Nicotinate drug interaction is moderate for most people, with concerns that call for awareness rather than alarm. None of the listed interactions are rated major, but all are rated moderate, and only a few are backed by solid human evidence.

Interactions deserving the most attention

The best-supported concern involves diabetes medications. Because the body converts inositol nicotinate to niacin, which can raise blood sugar, it may partly blunt the effect of glucose-lowering drugs, and closer blood sugar checks may be needed early on. There is also a theoretical bleeding concern with anticoagulant and antiplatelet drugs, since inositol nicotinate may help break down clots. With statins, niacin has been linked in case reports to muscle problems, though clinical studies have not confirmed a meaningfully higher risk.

What the rest of the list means

Although the list of interacting medications is long, most of these concerns trace back to a single fact: the body turns inositol nicotinate into niacin. Many predicted effects are theoretical, and some, like the statin muscle concern, have not produced clinically meaningful problems in studies. A long list does not mean every combination is harmful.

Check your medications against Inositol Nicotinate

Based on HelloPharmacist’s Inositol Nicotinate interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Inositol Nicotinate

223 medications have a known interaction with Inositol Nicotinate, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AbciximabReoPro
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Abciximab interaction
AbrocitinibCibinqo
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Inositol Nicotinate + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcenocoumarolSintrom
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Acenocoumarol interaction
Acetaminophen, AspirinGemnisyn
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, IbuprofenCombogesic
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Acetaminophen, Ibuprofen interaction
AcetohexamideDymelor
Moderate Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Inositol Nicotinate + Acetohexamide interaction
Acetylsalicylic AcidEntrophen
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Acetylsalicylic Acid interaction Acetylsalicylic Acid drug page: uses, dosage & side effects
AlbiglutideTanzeum
Moderate Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Inositol Nicotinate + Albiglutide interaction
AlogliptinNesina
Moderate Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Inositol Nicotinate + Alogliptin interaction Alogliptin drug page: uses, dosage & side effects
Alogliptin, MetforminKazano
Moderate Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Inositol Nicotinate + Alogliptin, Metformin interaction
Alogliptin, PioglitazoneOseni
Moderate Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Inositol Nicotinate + Alogliptin, Pioglitazone interaction
Alteplase, TpaActilyse, Activase
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Alteplase, Tpa interaction
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interaction
Aluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interaction Aluminum Hydroxide, Aspirin, Magnesium Hydroxide drug page: uses, dosage & side effects
Anacaulase-bcdbNexoBrid
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Anacaulase-bcdb interaction
AnagrelideAgrylin
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Anagrelide interaction Anagrelide drug page: uses, dosage & side effects
AnisindioneMiradon
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Anisindione interaction
Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Moderate Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Read the full Inositol Nicotinate + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interaction
Antithrombin IiiThrombate III
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Antithrombin Iii interaction
ApixabanEliquis
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Apixaban interaction Apixaban drug page: uses, dosage & side effects
ArgatrobanArgatroban
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Argatroban interaction
AspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aspirin interaction Aspirin drug page: uses, dosage & side effects
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interaction
Aspirin, ButalbitalAxotal
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aspirin, Butalbital interaction
Aspirin, Butalbital, CaffeineFiorinal
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aspirin, Butalbital, Caffeine interaction Aspirin, Butalbital, Caffeine drug page: uses, dosage & side effects
Aspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction
Aspirin, Butalbital, Caffeine, PhenacetinMarnal
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aspirin, Butalbital, Caffeine, Phenacetin interaction
Aspirin, CaffeineAnacin
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full Inositol Nicotinate + Aspirin, Caffeine interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Inositol Nicotinate combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Inositol Nicotinate affects

Every type of medication (drug category) Inositol Nicotinate is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 4 drug categories Inositol Nicotinate interacts with
Anticoagulant/antiplatelet DrugsAntidiabetes DrugsHmg-coa Reductase Inhibitors ("statins")Transdermal Nicotine (nicoderm)
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of inositol nicotinate with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Inositol nicotinate has fibrinolytic effects, which may increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Inositol nicotinate is metabolized to niacin in the body. Niacin can cause hyperglycemia, abnormal glucose tolerance, and glycosuria. Increased blood glucose monitoring may be necessary, particularly early in the course of treatment.

Likelihood Probable Evidence B
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of inositol nicotinate and statins might increase the risk of myopathy and rhabdomyolysis.
Inositol nicotinate is metabolized to niacin in the body. Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins However, a significantly increased risk of myopathy has not been demonstrated in clinical trials.

Likelihood Possible Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of inositol nicotinate and transdermal nicotine might increase the risk of flushing and dizziness.
Inositol nicotinate is metabolized to niacin in the body. Inositol nicotinate and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Monograph

Inositol Nicotinate: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Inositol nicotinate is a 'no-flush' form of niacin marketed for cholesterol and circulation. Evidence that it works as well as regular niacin is weak and inconsistent, and it is not a proven replacement for prescription cholesterol treatment. Talk to your pharmacist or doctor before using it, especially if you have liver problems or take other medicines.

Inositol Nicotinate
Part used
Synthetic compound (inositol bound to niacin/nicotinic acid)
Common forms
Tablets, capsules
People commonly use it for
  • Cholesterol support
  • Improving circulation
  • Raynaud's phenomenon
  • Intermittent claudication (leg pain with walking)
  • A 'no-flush' niacin alternative

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally tolerated short-term but evidence is limited and high-dose niacin compounds can affect the liver.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Inositol nicotinate (also called inositol hexaniacinate or inositol hexanicotinate) is a man-made compound that joins inositol with several molecules of niacin (nicotinic acid, a B vitamin). It is not a plant or herb — it is a chemical combination made in a lab.

It is often sold as a "no-flush niacin" because, unlike regular niacin, it tends to cause less of the warm, red flushing feeling on the skin. The idea is that the body slowly breaks it down to release niacin and inositol over time.

People commonly take it as a supplement for cholesterol, circulation, and conditions involving poor blood flow.

How it works

Once swallowed, inositol nicotinate is thought to slowly break down in the body to release niacin (nicotinic acid) and inositol. Niacin can affect how the body handles fats and may widen small blood vessels, which is the basis for the cholesterol and circulation claims.

Because the niacin is released slowly, blood levels rise more gently — which is why it causes less flushing. However, this same slow release may also mean it delivers less of niacin's cholesterol-changing effect.

These mechanisms are based largely on what is known about niacin in general and on limited human research. Much remains uncertain.

Effectiveness

Does Inositol Nicotinate work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 12 uses evaluated
1 Possibly effective 11 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Raynaud syndrome
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral inositol nicotinate may modestly improve symptoms in patients with Raynaud syndrome.

Also studied for 11 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for acne, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Anxiety
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for anxiety, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Cerebrovascular disease
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for cerebrovascular disease, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for hyperlipidemia, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for hypertension, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Intermittent claudication
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol nicotinate is beneficial in patients with intermittent claudication.

Insufficient Reliable Evidence To Rate Migraine headache
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for migraine headache, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Psoriasis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for psoriasis, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Restless legs syndrome (RLS)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for RLS, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Schizophrenia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for schizophrenia, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Insufficient Reliable Evidence To Rate Scleroderma
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol nicotinate for scleroderma, there is insufficient reliable information about the clinical effects of inositol nicotinate for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Inositol nicotinate is generally tolerated in the short term, but it has not been thoroughly studied for long-term safety. Because it is a niacin compound, high doses could potentially affect the liver, blood sugar, and uric acid levels.

Use caution and talk to a healthcare provider if you have liver disease, diabetes, gout, low blood pressure, a bleeding disorder, or active stomach ulcers. Stop use and seek care if you notice signs of liver trouble such as unusual tiredness, dark urine, or yellowing of the skin or eyes.

Pregnancy and breastfeeding: There is not enough reliable safety information, so it is best to avoid inositol nicotinate during pregnancy and while breastfeeding unless your doctor specifically recommends it.

Always tell your pharmacist or doctor about any supplement you take, especially before surgery.

Side effects

This form is marketed as causing less flushing than regular niacin, but some people may still notice mild warmth, itching, or skin redness.

Other possible side effects include upset stomach, nausea, headache, or low blood pressure (feeling dizzy or lightheaded).

Rarely, niacin-containing products taken in high doses can cause liver problems or raise blood sugar and uric acid. If you have any unusual symptoms, stop taking it and contact a healthcare provider.

Inositol Nicotinate: Reported Adverse Effects

Documented safety reports on Inositol Nicotinate from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, inositol nicotinate is generally well tolerated.

Most Common Adverse Effects:

Orally: Abdominal pain, constipation, diarrhea, flushing, heartburn, liver enzyme elevation, nausea, vomiting.

Reports by condition
Constipation Gastrointestinal

Orally, inositol nicotinate is converted to niacin and is therefore likely to cause similar side effects as niacin, including gastrointestinal complaints such as nausea, vomiting, bloating, heartburn, diarrhea, and constipation. These adverse effects from niacin may be reduced by taking it with meals or antacids, and usually disappear within two weeks of continued therapy.

  1. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  2. Gibbons LW, Gonzalez V, Gordon N, Grundy S. The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 1995;99:378-85.
  3. Figge HL, Figge J, Souney PF, et al. Nicotinic acid: a review of its clinical use in the treatment of lipid disorders. Pharmacotherapy 1988;8:287-94.
  4. Brown WV. Niacin for lipid disorders. Indications, effectiveness, and safety. Postgrad Med. 1995 Aug;98(2):185-9, 192-3.
Diabetes Endocrine

Orally, inositol nicotinate is converted to niacin and is therefore likely to cause similar side effects as niacin. Niacin can impair glucose tolerance in a dose-dependent manner. Dosages of niacin 3-5 grams daily appear to increase blood glucose in patients with or without diabetes, while dosages of 1.5 grams or less have minimal effects. Because inositol nicotinate is converted to niacin, it may also impair glucose tolerance.

  1. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  2. McKenney J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med 2004;164:697-705.
Dyslipidemia Cardiovascular

Orally, inositol nicotinate is converted to niacin and is therefore likely to cause similar side effects as niacin. A prostaglandin-mediated flushing reaction is a common adverse effect of oral niacin. A large pooled analysis of clinical studies shows that up to 70% of people may experience flushing with oral niacin. Although flushing can occur with doses of niacin as low as 30 mg daily, it is more common with the larger doses of 500-2000 mg used for treatment of dyslipidemia. Inositol nicotinate is often promoted as a "no-flush" niacin; however, this benefit has not been demonstrated in clinical trials.

  1. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  2. Schandelmaier S, Briel M, Saccilotto R, Olu KK, Arpagaus A, Hemkens LG, Nordmann AJ. Niacin for primary and secondary prevention of cardiovascular events. Cochrane Database Syst Rev. 2017 Jun 14;6:CD009744.
  3. Guyton JR, Goldberg AC, Kreisberg RA, et al. Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol 1998;82:737-43.
  4. Andersson RG, Aberg G, Brattsand R, Ericsson E, Lundholm L. Studies on the mechanism of flush induced by nicotinic acid. Acta Pharmacol Toxicol (Copenh). 1977 Jul;41(1):1-10.
  5. Aramwit P, Srisawadwong R, Supasyndh O. Effectiveness and safety of extended-release nicotinic acid for reducing serum phosphorus in hemodialysis patients. J Nephrol. 2012 May-Jun;25(3):354-62.
  6. He YM, Feng L, Huo DM, Yang ZH, Liao YH. Benefits and harm of niacin and its analog for renal dialysis patients: a systematic review and meta-analysis. Int Urol Nephrol. 2014 Feb;46(2):433-42.
Neonatal jaundice Hepatic

Orally, inositol nicotinate is converted to niacin and is therefore likely to cause similar side effects as niacin. Niacin is associated with elevated liver function tests and jaundice, especially with doses of 3 grams daily or more, and when doses are rapidly increased. Because inositol nicotinate is converted to niacin, it may also cause hepatotoxicity

  1. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  2. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32.
  3. American Society of Health-System Pharmacists. ASHP Therapeutic Position Statement on the safe use of niacin in the management of dyslipidemias. Am J Health Syst Pharm 1997;54:2815-9.
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  5. Figge HL, Figge J, Souney PF, et al. Nicotinic acid: a review of its clinical use in the treatment of lipid disorders. Pharmacotherapy 1988;8:287-94.
Pruritus Dermatologic

Orally, inositol nicotinate is converted to niacin and is therefore likely to cause similar side effects as niacin, including pruritus.

  1. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established standard dose for inositol nicotinate, and products vary widely. Studies have used different amounts, so there is no single proven dose.

The safest approach is to follow the directions on the product label and check with your pharmacist or doctor before starting, especially if you take other medicines or have a health condition. Do not assume a higher dose is safer or more effective.

Pregnancy & Breastfeeding

Inositol Nicotinate & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Inositol Nicotinate & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 21 references that drive our Inositol Nicotinate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  2. Holti G. An experimentally controlled evaluation of the effect of inositol nicotinate upon the digital blood flow in patients with Raynaud's phenomenon. J Int Med Res 1979;7:473-83. PubMed
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Gibbons LW, Gonzalez V, Gordon N, Grundy S. The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 1995;99:378-85. PubMed
  5. Crouse JR III. New developments in the use of niacin for treatment of hyperlipidemia: new considerations in the use of an old drug. Coron Artery Dis 1996;7:321-6. PubMed
  6. Garg A, Grundy SM. Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. JAMA 1990;264:723-6. DOI
  7. American Society of Health-System Pharmacists. ASHP Therapeutic Position Statement on the safe use of niacin in the management of dyslipidemias. Am J Health Syst Pharm 1997;54:2815-9. DOI
  8. Guyton JR, Goldberg AC, Kreisberg RA, et al. Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol 1998;82:737-43.
  9. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  10. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  11. Bays HE, Dujovne CA. Drug interactions of lipid-altering drugs. Drug Saf 1998;19:355-71. PubMed
  12. Figge HL, Figge J, Souney PF, et al. Nicotinic acid: a review of its clinical use in the treatment of lipid disorders. Pharmacotherapy 1988;8:287-94. PubMed
  13. McKenney J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med 2004;164:697-705. PubMed
  14. Reaven P, Witztum JL. Lovastatin, nicotinic acid and rhabdomyolysis (letter). Ann Int Med 1988;109:597-8. PubMed
  15. Ito MK. Advances in the understanding and management of dyslipidemia: using niacin-based therapies. Am J Health-Syst Pharm 2003;60(suppl 2):s15-21. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Inositol Nicotinate

75 brands in our database make a supplement containing Inositol Nicotinate.

Product directory

Supplement products with Inositol Nicotinate

206 products in our database contain Inositol Nicotinate. Open any to see its full ingredient list and every drug interaction we check.

Flush-free Niacin 500 mg by Nature Made Softgel Capsule 120 Softgel(s) View ingredients & interactions Flush-Free Niacin 500 mg by Nature Made Softgel Capsule 60 Softgel(s) View ingredients & interactions Flush-Free Niacin 500 mg by Protocol For Life Balance Capsule 90 Veg Capsule(s) View ingredients & interactions Flush-Free Niacin 500 mg by Protocol For Life Balance Capsule 90 Veg Capsule(s) View ingredients & interactions Flush-Free Niacin 500 mg by Patient One 1 MediNutritionals Capsule 120 Vegetable Capsule(s) View ingredients & interactions Flush-Free Niacin 500 mg by Patient One 1 MediNutritionals Capsule 60 Vegetable Capsule(s) View ingredients & interactions Full Focus by Neurobiologix Capsule 120 Vegetable Capsule(s) View ingredients & interactions Glyco Results by Physician's Signature Other (e.g. Tea Bag) 60 Caplet(s) View ingredients & interactions Gugu Lipo by Priority One Nutritional Supplements Capsule 120 Vegetarian Capsule(s) View ingredients & interactions Hair Skin Nail Essentials by 1st Phorm Capsule 90 Vegan Capsule(s) View ingredients & interactions Heart Savior by New Health Capsule 120 Capsule(s) View ingredients & interactions Heart Savior by New Health Capsule 120 Capsule(s) View ingredients & interactions Heart Savior by New Health Corp. Capsule 120 Capsule(s) View ingredients & interactions Higher Mind by Source Naturals Tablet Or Pill 90 Tablet(s) View ingredients & interactions Higher Mind With Phosphatidylserine by Source Naturals Tablet Or Pill 30 Tablet(s) View ingredients & interactions Inositol Hexanicotinate by SuperSmart Capsule 90 Vegetarian Capsule(s) View ingredients & interactions Inositol Hexanicotinate 1500 mg by SuperSmart Capsule 90 Vegetarian Capsule(s) View ingredients & interactions Inositol Nicotinate + Cr by Genestra Brands Capsule 60 Vegetable Capsule(s) View ingredients & interactions Inositol Nicotinate + Cr by Genestra Brands Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Isotropin Rejuvenation Tangerine Flavor by NewtonEverett Other (e.g. Tea Bag) 20 Effervescent Sachet(s) · 15.6 Oz(s) · 441.4 Gram(s) View ingredients & interactions Isotropin Rejuvenation Tangerine Flavor Effervescent Packets by NewtonEverett Powder 20 Effervescent Packet(s) · 15.6 Ounce(s) · 441.4 Gram(s) View ingredients & interactions Lipid Balance by Progressive Professional from Progressive Laboratories Capsule 180 Vegetable Capsule(s) View ingredients & interactions Lipid Results by Physician's Signature Other (e.g. Tea Bag) 180 Caplet(s) View ingredients & interactions LipidOptimal by Karuna Capsule 180 Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Inositol Nicotinate: Common Questions

What is Inositol Nicotinate used for, and does it work?
People use Inositol Nicotinate for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Inositol Nicotinate for Raynaud syndrome. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Inositol Nicotinate interact with prescription medications?
Yes. We list 223 medications with a known interaction with Inositol Nicotinate. Use the checker above to see how Inositol Nicotinate interacts with a specific drug.
How are Inositol Nicotinate interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Inositol Nicotinate with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Inositol Nicotinate interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Inositol Nicotinate the same as regular niacin?
Not exactly. It is a compound that slowly releases niacin in the body, which is why it is sold as a 'no-flush' niacin. Because of this slow release, it may not work the same way regular or prescription niacin does for cholesterol.
Does Inositol Nicotinate really cause less flushing?
It is marketed as 'no-flush' because the niacin is released slowly, so most people get less of the warm, red flushing. However, some people may still notice mild skin warmth or redness.
Can I use it instead of my prescription cholesterol medicine?
No. The evidence that it lowers cholesterol is weak, and it should not replace a proven, prescribed treatment. Talk to your doctor before changing any cholesterol medication.
Is it safe during pregnancy or breastfeeding?
There is not enough safety information, so it is best to avoid it during pregnancy and breastfeeding unless your doctor specifically advises otherwise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Inositol Nicotinate

A rotating sample of real supplements in our database that list Inositol Nicotinate — open any to see its full ingredients and every drug interaction we check.

See all 206 products with Inositol Nicotinate →
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