Herb & supplement monograph

Sida Cordifolia Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Sida Cordifolia interacts with medications. The heart of this page is the interaction list — every drug Sida Cordifolia is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Sida Cordifolia is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Sida Cordifolia Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the risk of clinically significant Sida Cordifolia drug interactions is real and worth taking seriously, because this herb contains ephedrine, a stimulant with well-documented effects on the heart and blood pressure. Most of the listed interactions are rated major, and none are minor.

Interactions deserving the most attention

The strongest concerns involve QT interval-prolonging drugs, since human research shows ephedrine can affect heart rhythm, and stimulant drugs, including caffeine, where combined use raises the risk of high blood pressure and other cardiovascular effects. Sida cordifolia may also raise blood pressure when combined with MAOIs or ergot medicines. People taking diabetes medications should know ephedrine can raise blood sugar and may work against those drugs.

What the rest of the list means

The long list here reflects one shared mechanism rather than hundreds of separate problems: nearly every interaction traces back to the ephedrine this plant contains. Many entries are extrapolated from studies of ephedrine or ephedra rather than Sida cordifolia itself, so not every combination has been directly tested. Still, ephedrine's stimulant effects in people are well established, which is why so many of these interactions carry a serious rating.

Check your medications against Sida Cordifolia

Based on HelloPharmacist’s Sida Cordifolia interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Sida Cordifolia

445 medications have a known interaction with Sida Cordifolia, graded by severity. Select any drug for the full evidence-based detail.

337 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Sida Cordifolia.

2,830 drugs
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG› Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid› Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR› Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus› Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more› Acetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus› Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil› Acetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A› Acetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss› Acetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough› Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps› Acetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength› Acetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine› Acetaminophen, Dichloralphenazone, IsomethepteneMidrin› Acetaminophen, Dichlorophenazone, IsometheptaneIsocom›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Sida Cordifolia combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Sida Cordifolia affects

Every type of medication (drug category) Sida Cordifolia is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 7 drug categories Sida Cordifolia interacts with
MethylxanthinesQt Interval-prolonging DrugsStimulant DrugsAntidiabetes DrugsDexamethasone (decadron)Ergot DerivativesMonoamine Oxidase Inhibitors (maois)
Methylxanthines

Theoretically, Sida cordifolia might increase the risk of serious adverse effects when taken with methylxanthines.
Sida cordifolia contains ephedrine. Use of ephedrine-containing herbs with caffeine or other methylxanthines such as theophylline might increase the risk of stimulatory adverse effects. Some clinical research and case reports suggest that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction (MI), stroke, seizures, and death.

Likelihood Probable Evidence D
Qt Interval-Prolonging Drugs

Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.
Sida cordifolia contains ephedrine. Clinical research shows that ephedrine from another herb, ephedra, can prolong the QT interval.

Likelihood Probable Evidence B
Stimulant Drugs

Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.
Sida cordifolia contains ephedrine. Drugs with CNS stimulant properties, such as phenylpropanolamine, pseudoephedrine, and diethylpropion, and many others can increase the risk of hypertension and adverse cardiovascular effects when taken with ephedrine.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, Sida cordifolia might reduce the effectiveness of antidiabetes drugs.
Sida cordifolia contains ephedrine. Clinical research shows that ephedrine can increase blood glucose levels.

Likelihood Probable Evidence B
Dexamethasone (Decadron)

Theoretically, Sida cordifolia might reduce the effectiveness of dexamethasone.
Sida cordifolia contains ephedrine. Clinical research shows that ephedrine can increase the clearance rate of dexamethasone.

Likelihood Possible Evidence B
Ergot Derivatives

Theoretically, Sida cordifolia might increase the risk of additive hypertension when taken with ergot derivatives.
Sida cordifolia contains ephedrine, which can cause vasoconstriction. This can lead to significant elevations in blood pressure when taken with ergot derivatives.

Likelihood Probable Evidence B
Monoamine Oxidase Inhibitors (Maois)

Theoretically, Sida cordifolia might increase the risk of hypertension when taken with MAOIs.
Sida cordifolia contains ephedrine. Clinical research shows that ephedrine can increase blood pressure.

Likelihood Probable Evidence B
Monograph

Sida Cordifolia: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Sida cordifolia (bala or country mallow) is a traditional Ayurvedic plant that naturally contains ephedrine, a powerful stimulant. Because of this, many supplements containing it have been banned or restricted, and it carries real risks to the heart and blood pressure. There is little reliable human evidence that it works, so most people should avoid it and talk with a pharmacist or doctor first.

Sida Cordifolia
Scientific name
Sida cordifolia
Family
Malvaceae
Part used
Whole plant, including roots, seeds, leaves, and stems
Common forms
Capsules, powders, dried herb, teas, and traditional Ayurvedic preparations
People commonly use it for
  • Weight loss and energy
  • Asthma and breathing problems
  • Joint and muscle pain
  • Fever and cough
  • General fatigue or 'tonic'

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

It contains ephedrine, a stimulant linked to serious heart and blood pressure risks, and is banned in many products.

PregnancyLikely Unsafe

When used orally. The ephedrine constituent of Sida cordifolia has been linked to several cases of severe side effects.

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When used orally. The ephedrine constituent of Sida cordifolia has been linked to several cases of severe side effects.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Sida cordifolia is a flowering plant in the mallow family (Malvaceae). It is native to India and now grows in many warm, tropical parts of the world. In Ayurvedic medicine it is often called bala, and it has also been marketed as 'country mallow' or 'Indian ephedra.'

Traditionally, the whole plant has been used for many purposes, including fever, cough, asthma, joint pain, and as a general strengthening 'tonic.' More recently, it has been added to weight-loss, energy, and athletic supplements because it naturally contains ephedrine, a stimulant.

It is important to know that ephedrine and ephedra-containing supplements are banned or heavily restricted in many countries because of safety concerns. This makes Sida cordifolia a plant to approach with real caution.

Uses & effectiveness

People have used Sida cordifolia for a long list of conditions, but strong human evidence is largely missing for nearly all of them.

  • Weight loss and energy: The ephedrine in the plant can act as a stimulant, but ephedrine for weight loss is linked to serious safety problems and is not recommended.
  • Asthma and breathing: Ephedrine can open airways, which is part of the traditional logic, but using a raw, unstandardized plant for asthma is risky and not supported by good studies.
  • Joint and muscle pain, fever, cough: These traditional uses come mainly from Ayurvedic practice and laboratory or animal studies, not solid clinical trials in people.

Overall, the available evidence is weak and mostly preliminary. Much of what we know comes from test-tube and animal research, which does not prove the plant is safe or effective in humans.

How it works

Sida cordifolia contains several plant compounds, but the most notable is ephedrine (and related alkaloids). Ephedrine is a stimulant that can speed up the heart, raise blood pressure, widen airways, and slightly increase how many calories the body burns. This is why the plant has been used for energy, weight loss, and breathing problems.

The plant also contains other compounds that, in laboratory studies, have shown possible anti-inflammatory and antioxidant activity. However, these effects have mostly been seen in cells or animals, not in well-designed human trials.

Because the amount of ephedrine in any given product can vary a lot, the effects—and the risks—can be unpredictable.

Safety & precautions

The biggest safety concern is the ephedrine content. Ephedrine and ephedra-type ingredients have been linked to heart attacks, stroke, dangerous heart rhythms, very high blood pressure, and even deaths, especially in weight-loss and energy products. Because of this, the U.S. FDA banned dietary supplements containing ephedrine alkaloids, and Sida cordifolia falls into this category of concern.

People who should avoid this plant include anyone with high blood pressure, heart disease, an irregular heartbeat, anxiety, thyroid problems, diabetes, glaucoma, or a history of seizures. It should also be avoided before surgery.

Pregnancy and breastfeeding: Avoid Sida cordifolia if you are pregnant or breastfeeding. Stimulants like ephedrine can be harmful to a developing baby and can pass into breast milk.

Always talk with a pharmacist or doctor before using any product that contains Sida cordifolia.

Side effects

Because of the ephedrine it contains, Sida cordifolia can cause stimulant-type side effects, including:

  • Fast or pounding heartbeat
  • Increased blood pressure
  • Restlessness, anxiety, or trouble sleeping
  • Headache, dizziness, or tremor
  • Nausea or upset stomach

Rare but serious problems can include dangerous heart rhythms, heart attack, stroke, and seizures. The risk goes up at higher doses, with other stimulants (including caffeine), and in people with heart or blood pressure conditions. Stop use and seek medical care right away if you have chest pain, fainting, severe headache, or an irregular heartbeat.

Sida Cordifolia: Reported Adverse Effects

Documented safety reports on Sida Cordifolia from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Anorexia Neurologic/CNS

Sida cordifolia contains ephedrine. Ephedrine-containing products have been associated with dizziness, restlessness, irritability, difficulty concentrating, insomnia, headache, and anorexia. These side effects might also occur in patients taking Sida cordifolia-containing supplements.

  1. Doyle H, Kargin M. Herbal stimulant containing ephedrine has also caused psychosis. BMJ 1996;313:756.
  2. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24.
  3. Gurley BJ, Gardner SF, Hubbard MA. Content versus label claims in ephedra-containing dietary supplements. Am J Health Syst Pharm 2000;57:963-9.
  4. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8.
  5. Boozer CN, Daly PA, Homel P, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 2002;26:593-604.
  6. Kalman D, Incledon T, Gaunaurd I, et al. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra-caffeine weight loss product in healthy overweight adults. Int J Obes 2002;26:1363-66..
  7. Yates KM, O'Connor A, Horsley CA. "Herbal Ecstasy": a case series of adverse reactions. N Z Med J 2000;113:315-7..
Anxiety Psychiatric

Sida cordifolia contains ephedrine. Ephedrine-containing products have been associated with anxiety, psychosis, and personality changes. Long-term use and high doses of ephedrine have been associated with the development of dependence and tolerance. These side effects might also occur in patients taking Sida cordifolia-containing supplements.

  1. Doyle H, Kargin M. Herbal stimulant containing ephedrine has also caused psychosis. BMJ 1996;313:756.
  2. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24.
  3. Gurley BJ, Gardner SF, Hubbard MA. Content versus label claims in ephedra-containing dietary supplements. Am J Health Syst Pharm 2000;57:963-9.
  4. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8.
  5. Jacobs KM, Hirsch KA. Psychiatric complications of Ma-huang. Psychosomatics 2000;41:58-62.
  6. Boozer CN, Daly PA, Homel P, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 2002;26:593-604.
  7. Kalman D, Incledon T, Gaunaurd I, et al. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra-caffeine weight loss product in healthy overweight adults. Int J Obes 2002;26:1363-66..
  8. Yates KM, O'Connor A, Horsley CA. "Herbal Ecstasy": a case series of adverse reactions. N Z Med J 2000;113:315-7..
  9. Walton R, Manos GH. Psychosis related to ephedra-containing herbal supplement use. South Med J 2003;96:718-20..
  10. FDA Takes Aim at Ephedra. The Washington Post. Available at: http://www.washingtonpost.com/archive/politics/2000/03/19/fda-takes-aim-at-ephedra/4ce534a7-d291-44ec-88a8-38e97ff27e3b/ (Accessed 19 March 2000).
Cardiac arrest Cardiovascular

Sida cordifolia contains ephedrine. Ephedrine-containing products have been associated with cardiovascular side effects such as arrythmias, heart palpitations, tachycardia, prolonged QT interval, increased blood pressure, cardiomyopathy, hypersensitivity myocarditis, myocardial infarction, cardiac arrest, stroke, transient ischemic attack, cerebral hemorrhage, and sudden cardiac death. These side effects might also occur in patients taking Sida cordifolia-containing supplements.

  1. Okada S, Rohan PJ, Miller FW, et al. Myopathies following ingestion of special nutritional products. Arthritis Rheum 1996;39:349.
  2. Zaacks SM, Klein L, Tan CD, et al. Hypersensitivity myocarditis associated with ephedra use. J Toxicol Clin Toxicol 1999;37:485-9.
  3. Theoharides TC. Sudden death of a healthy college student related to ephedrine toxicity from a ma-huang containing drink. J Clin Psychopharmacol 1997;17:437-9.
  4. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  5. Doyle H, Kargin M. Herbal stimulant containing ephedrine has also caused psychosis. BMJ 1996;313:756.
  6. For Dieter, Nearly the Ultimate Loss. The Washington Post. Available at: http://www.washingtonpost.com/archive/politics/2000/03/19/for-dieter-nearly-the-ultimate-loss/c0f07474-489d-4f44-bc17-1f1367c956ae/ (Accessed 19 March 2000).
  7. FDA Takes Aim at Ephedra. The Washington Post. Available at: http://www.washingtonpost.com/archive/politics/2000/03/19/fda-takes-aim-at-ephedra/4ce534a7-d291-44ec-88a8-38e97ff27e3b/ (Accessed 19 March 2000).
  8. FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).
  9. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24.
  10. Gurley BJ, Gardner SF, Hubbard MA. Content versus label claims in ephedra-containing dietary supplements. Am J Health Syst Pharm 2000;57:963-9.
  11. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8.
  12. Leikin JB, Klein L. Ephedra causes myocarditis. Clin Toxicol 2000;38:353-4.
  13. Samenuk D, Link MS, Homoud MK, et al. Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine. Mayo Clin Proc 2002;77:12-6.
  14. Boozer CN, Daly PA, Homel P, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 2002;26:593-604.
  15. Kalman D, Incledon T, Gaunaurd I, et al. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra-caffeine weight loss product in healthy overweight adults. Int J Obes 2002;26:1363-66..
  16. Yates KM, O'Connor A, Horsley CA. "Herbal Ecstasy": a case series of adverse reactions. N Z Med J 2000;113:315-7..
  17. Jenkins DJ, Wesson V, Wolever TM, et al. Wholemeal versus wholegrain breads: proportion of whole or cracked grain and the glycaemic response. BMJ 1988;297:958-60.
  18. Gardner SF, Franks AM, Gurley BJ, et al. Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteers. Am J Cardiol 2003;91:1510-3, A9.
Kidney stones (nephrolithiasis) Renal

Sida cordifolia contains ephedrine. Ephedrine-containing products have been reported to cause rhabdomyolysis and nephrolithiasis. These side effects might also occur in patients taking Sida cordifolia-containing supplements.

  1. Okada S, Rohan PJ, Miller FW, et al. Myopathies following ingestion of special nutritional products. Arthritis Rheum 1996;39:349.
  2. Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis 1998;32:153-9.
Muscle breakdown Musculoskeletal

Sida cordifolia contains ephedrine. Ephedrine-containing products have been reported to cause myopathies, including myalgia, rhabdomyolysis, and eosinophilia-myalgia syndrome. These side effects might also occur in patients taking Sida cordifolia-containing supplements.

  1. Okada S, Rohan PJ, Miller FW, et al. Myopathies following ingestion of special nutritional products. Arthritis Rheum 1996;39:349.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established safe or standardized dose for Sida cordifolia, and the amount of ephedrine in a product can vary widely and unpredictably. Because of the serious safety concerns, we cannot recommend a specific dose.

If you are considering any product that contains Sida cordifolia, follow the product label and—more importantly—check with a pharmacist or doctor first. Many health authorities recommend avoiding ephedrine-containing supplements entirely.

Pregnancy & Breastfeeding
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 29 references that drive our Sida Cordifolia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Okada S, Rohan PJ, Miller FW, et al. Myopathies following ingestion of special nutritional products. Arthritis Rheum 1996;39:349.
  2. Zaacks SM, Klein L, Tan CD, et al. Hypersensitivity myocarditis associated with ephedra use. J Toxicol Clin Toxicol 1999;37:485-9. PubMed
  3. Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis 1998;32:153-9. PubMed
  4. Theoharides TC. Sudden death of a healthy college student related to ephedrine toxicity from a ma-huang containing drink. J Clin Psychopharmacol 1997;17:437-9. PubMed
  5. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  6. Doyle H, Kargin M. Herbal stimulant containing ephedrine has also caused psychosis. BMJ 1996;313:756. PubMed
  7. For Dieter, Nearly the Ultimate Loss. The Washington Post. Available at: http://www.washingtonpost.com/archive/politics/2000/03/19/for-dieter-nearly-the-ultimate-loss/c0f07474-489d-4f44-bc17-1f1367c956ae/ (Accessed 19 March 2000).
  8. FDA Takes Aim at Ephedra. The Washington Post. Available at: http://www.washingtonpost.com/archive/politics/2000/03/19/fda-takes-aim-at-ephedra/4ce534a7-d291-44ec-88a8-38e97ff27e3b/ (Accessed 19 March 2000).
  9. FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).
  10. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. PubMed
  11. Anon. Sida Cordifolia. Metro Marketing, Inc. Available at: http://metromkt.net/viable/1sidacor.shtml (Accessed 9 March 2000).
  12. Gurley BJ, Gardner SF, Hubbard MA. Content versus label claims in ephedra-containing dietary supplements. Am J Health Syst Pharm 2000;57:963-9. PubMed
  13. White LM, Gardner SF, Gurley BJ, et al. Pharmacokinetics and Cardiovascular Effects of Ma-Huang (Ephedra sinica) in Normotensive Adults. J Clin Pharmacol 1997;37:116-22.
  14. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. PubMed
  15. Leikin JB, Klein L. Ephedra causes myocarditis. Clin Toxicol 2000;38:353-4.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Sida Cordifolia

13 brands in our database make a supplement containing Sida Cordifolia.

Product directory

Supplement products with Sida Cordifolia

48 products in our database contain Sida Cordifolia. Open any to see its full ingredient list and every drug interaction we check.

Sida Acuta 20:1 Concentrated Extract by Samsara Herbs Powder 2 Ounce(s) · 57 Gram(s) View ingredients & interactions Sida Acuta 20:1 Concentrated Extract by Samsara Herbs Powder 8 Ounce(s) · 227 Gram(s) View ingredients & interactions StressCare by Himalaya Capsule 120 Vegetarian Capsule(s) View ingredients & interactions StressCare by Himalaya Capsule 120 Vegetarian Capsule(s) View ingredients & interactions StressCare by Himalaya Capsule 240 Vegetarian Capsule(s) View ingredients & interactions Chyavanprash by Himalaya Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions Chyavanprash by Himalaya Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions Chyavanprash by Himalaya Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions Diablos ECA Fire Caps by Innovative Laboratories Capsule 100 Capsule(s) Off market View ingredients & interactions Diablos ECA Fire Caps by Innovative Bio-Labs Capsule 100 Capsule(s) Off market View ingredients & interactions ImmunoCare by Himalaya Capsule 240 Vegetarian Capsule(s) Off market View ingredients & interactions ImmunoCare by Himalaya Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions ImmunoCare by Himalaya Capsule 240 Vegetarian Capsule(s) Off market View ingredients & interactions ImmunoCare by Himalaya Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions MenoCare by Himalaya Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions MenoCare by Himalaya Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions MenoCare by Himalaya Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions Padma Basic by ecoNugenics Capsule 180 Capsule(s) Off market View ingredients & interactions Sida Acuta by Samsara Herbs Powder 2 Ounce(s) · 57 Gram(s) Off market View ingredients & interactions StressCare by Himalaya Capsule 240 Vegetarian Capsule(s) Off market View ingredients & interactions StressCare by Himalaya Capsule 240 Vegetarian Capsule(s) Off market View ingredients & interactions StressCare by Himalaya Capsule 240 Vegetarian Capsule(s) Off market View ingredients & interactions StressCare by Himalaya Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions StressCare by Himalaya Capsule 120 Vegetarian Capsule(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Sida Cordifolia: Common Questions

Does Sida Cordifolia interact with prescription medications?
Yes. We list 445 medications with a known interaction with Sida Cordifolia, including 337 rated major. Use the checker above to see how Sida Cordifolia interacts with a specific drug.
How are Sida Cordifolia interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Sida Cordifolia with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Sida Cordifolia interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Sida Cordifolia used for?
Traditionally it has been used for fever, cough, asthma, joint pain, and as an energy or weight-loss aid. However, good human evidence supporting these uses is largely lacking.
Is Sida Cordifolia safe?
It is generally considered risky because it naturally contains ephedrine, a stimulant linked to heart attacks, stroke, and high blood pressure. Many countries have banned or restricted supplements containing it.
Can I take Sida Cordifolia for weight loss?
It is not recommended. The ephedrine it contains can cause serious heart and blood pressure problems, which is why ephedrine-based weight-loss products were banned in the United States.
Is it safe during pregnancy or breastfeeding?
No. Because of its stimulant content, you should avoid Sida Cordifolia if you are pregnant or breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Sida Cordifolia

A rotating sample of real supplements in our database that list Sida Cordifolia — open any to see its full ingredients and every drug interaction we check.

See all 48 products with Sida Cordifolia →
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