Medication interaction hub

What Supplements Interact with Sitaxsentan sodium?

Sitaxsentan sodium brand name: Thelin. Every interaction below applies to the brands too.

173 Interactions 7 Major 145 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Sitaxsentan sodium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Sitaxsentan sodium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Sitaxsentan (Thelin) treats pulmonary arterial hypertension and carries a well known liver warning of its own, which is exactly why I read this list of 173 interacting supplements with genuine concern rather than a shrug. Most entries, 119 of them, either add to its blood pressure lowering effect or work against it, but the group I would understand first is the 38 ingredients tied to liver injury, including plain alcohol and Siberian cocklebur, one of the seven rated major.

The rest of the picture is quieter. Activated charcoal can soak up the drug in the gut before it has a chance to work, so space the two well apart, and a small handful of ingredients slow the enzyme that clears sitaxsentan, nudging its level upward. With 145 moderate and 21 minor entries sitting behind those seven majors, the sensible move is checking any product on this page against the full report before you swallow it.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 145 Minor 21 No known interaction 1,279

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Sitaxsentan sodium: Top Interactions at a Glance

The most significant Sitaxsentan sodium supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 173 interacting ingredients — plus 1,279 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Sitaxsentan sodium + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Sitaxsentan sodiumi

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Sitaxsentan sodiumi

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Likely Tyramine + Sitaxsentan sodiumi

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Sitaxsentan sodiumi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Sitaxsentan sodiumi

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Beer + Sitaxsentan sodiumi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Sitaxsentan sodium

All 1,452 ingredients in our database, ranked by severity — 173 with a Sitaxsentan sodium interaction on file and 1,279 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Sitaxsentan sodium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Delta-9-tetrahydrocannabinol (thc) with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that are CYP2C9 inhibitors might increase the levels and adverse effects of THC.

Full Delta-9-tetrahydrocannabinol (thc) + Sitaxsentan sodium answer

Can you take N-methyltyramine with Sitaxsentan sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In animal research, N-methyltyramine increased blood pressure.

Full N-methyltyramine + Sitaxsentan sodium answer

Can you take Casein Peptides with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.

Full Casein Peptides + Sitaxsentan sodium answer

Can you take Cat's Claw with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.

Full Cat's Claw + Sitaxsentan sodium answer

Can you take Celery with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Full Celery + Sitaxsentan sodium answer

Can you take Coca with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antihypertensive drugs.

Full Coca + Sitaxsentan sodium answer

Can you take Cod Liver Oil with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.

Full Cod Liver Oil + Sitaxsentan sodium answer

Can you take Coffee Charcoal with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Sitaxsentan sodium answer

Can you take Docosahexaenoic Acid (dha) with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Full Docosahexaenoic Acid (dha) + Sitaxsentan sodium answer

Can you take Eicosapentaenoic Acid (epa) with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking EPA with antihypertensive drugs might increase the risk of hypotension.

Full Eicosapentaenoic Acid (epa) + Sitaxsentan sodium answer

Can you take European Mandrake with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Sitaxsentan sodium answer

Can you take Fever Bark with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might alter the effects of antihypertensive drugs.

Full Fever Bark + Sitaxsentan sodium answer

Can you take Fish Oil with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Sitaxsentan sodium answer

Can you take Glucomannan with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Sitaxsentan sodium answer

Can you take Japanese Persimmon with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Japanese persimmon is thought to have hypotensive effects.

Full Japanese Persimmon + Sitaxsentan sodium answer

Can you take Java Tea with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some preliminary clinical evidence suggests that Java tea has antihypertensive effects.

Full Java Tea + Sitaxsentan sodium answer

Can you take L-arginine with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.

Full L-arginine + Sitaxsentan sodium answer

Can you take Olive Oil with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking olive oil with antihypertensive drugs might have additive effects on blood pressure.

Full Olive Oil + Sitaxsentan sodium answer

Can you take Periwinkle with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constitu...

Full Periwinkle + Sitaxsentan sodium answer

Can you take Sesame with Sitaxsentan sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking sesame oil with antihypertensive drugs might increase the risk of hypotension.

Full Sesame + Sitaxsentan sodium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Sitaxsentan sodium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Sitaxsentan sodium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Sitaxsentan sodium sits in 4 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Sitaxsentan sodium through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Sitaxsentan sodium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Sitaxsentan sodium through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Sitaxsentan sodium through this category.

Related: does Sitaxsentan sodium deplete any nutrients?

Sitaxsentan sodium has 1 reported nutrient association in the research literature — see the Sitaxsentan sodium nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Sitaxsentan sodium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Sitaxsentan sodium.

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Pharmacist Counseling Corner

Sitaxsentan sodium & Supplements: Common Questions

What supplements interact with Sitaxsentan sodium?
More than you might expect — 173 in total, though they are far from equal: 7 are rated major, 145 moderate, and 21 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Sitaxsentan sodium supplement interactions are the most serious?
The 7 major-rated combinations — led by American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Sitaxsentan sodium?
Usually yes — most people on Sitaxsentan sodium can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Thelin have the same supplement interactions as Sitaxsentan sodium?
Yes — Thelin all contain Sitaxsentan sodium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Sitaxsentan sodium deplete any vitamins or nutrients?
It might — Sitaxsentan sodium has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Sitaxsentan sodium nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Sitaxsentan sodium and my other medications?
This page covers Sitaxsentan sodium against supplements and herbal ingredients. Checking Sitaxsentan sodium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.