Medication interaction hub

What Supplements Interact with Nateglinide?

Nateglinide brand name: Starlix. Every interaction below applies to the brands too.

290 Interactions 2 Major 241 Moderate 47 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nateglinide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nateglinide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People who take nateglinide (Starlix) with meals for type 2 diabetes are often drawn to supplements marketed for blood sugar, and that overlap is why these 290 interactions warrant real caution. Some 239 of the ingredients affect blood sugar on their own, most pushing it lower, so stacking them on nateglinide raises the odds of hypoglycemia, blood sugar dropping into shakiness, sweating, or confusion. Two rate major: Siberian cocklebur, which has caused severe hypoglycemia in humans, and activated charcoal, which can pull the drug out of the body before it works.

Another 64 can slow the liver enzyme that clears nateglinide, letting its effect build, and a smaller group blunts absorption of any pill taken by mouth; space those well apart from your dose. Beyond the majors, 241 rate moderate and 47 minor, and most trace back to the same outcome, a glucose reading lower than you expected.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 241 Minor 47 No known interaction 1,162

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Nateglinide: Top Interactions at a Glance

The most significant Nateglinide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 290 interacting ingredients — plus 1,162 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Nateglinide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Nateglinidei

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction Major Likelihood Probable Activated Charcoal + Nateglinidei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Nateglinide

All 1,452 ingredients in our database, ranked by severity — 290 with a Nateglinide interaction on file and 1,162 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nateglinide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Chromium with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Full Chromium + Nateglinide answer

Can you take Artemisia Herba-alba with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might increase the risk of hypoglycemia.

Full Artemisia Herba-alba + Nateglinide answer

Can you take L-cysteine with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.

Full L-cysteine + Nateglinide answer

Can you take Licorice with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.

Full Licorice + Nateglinide answer

Can you take Limonene with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9), as well causing its induction.

Full Limonene + Nateglinide answer

Can you take Lion's Mane Mushroom with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.

Full Lion's Mane Mushroom + Nateglinide answer

Can you take Lotus with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lotus might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Full Lotus + Nateglinide answer

Can you take Lychee with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Lychee + Nateglinide answer

Can you take Madagascar Periwinkle with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Madagascar periwinkle lowers blood glucose levels in diabetic rats.

Full Madagascar Periwinkle + Nateglinide answer

Can you take Maitake Mushroom with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Maitake Mushroom + Nateglinide answer

Can you take Manchurian Thorn with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that saponins isolated from Manchurian thorn can lower plasma glucose levels.

Full Manchurian Thorn + Nateglinide answer

Can you take Maritime Pine with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Maritime Pine + Nateglinide answer

Can you take Melatonin with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Melatonin + Nateglinide answer

Can you take Milk Thistle with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Full Milk Thistle + Nateglinide answer

Can you take Miracle Fruit with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, miracle fruit leaf might have an additive effect with antidiabetes drugs and increase the risk of hypoglycemia.

Full Miracle Fruit + Nateglinide answer

Can you take Myrrh with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, myrrh might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Myrrh + Nateglinide answer

Can you take Neem with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP2C9 substrates.

Full Neem + Nateglinide answer

Can you take Oats with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.

Full Oats + Nateglinide answer

Can you take Octacosanol with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.

Full Octacosanol + Nateglinide answer

Can you take Oleic Acid with Nateglinide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oleic acid might increase the effects of antidiabetes drugs.

Full Oleic Acid + Nateglinide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nateglinide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nateglinide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nateglinide sits in 3 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Nateglinide through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Nateglinide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Nateglinide through this category.

About Nateglinide

Nateglinide is an oral diabetes medicine used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes.

Generic name: Nateglinide  ·  Brand name: Starlix.

See the full Nateglinide drug information

Related: does Nateglinide deplete any nutrients?

Nateglinide has 1 reported nutrient association in the research literature — see the Nateglinide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nateglinide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nateglinide.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Nateglinide & Supplements: Common Questions

What supplements interact with Nateglinide?
Our database currently documents 290 ingredients with a known Nateglinide interaction (2 major, 241 moderate, 47 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 290. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Nateglinide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Nateglinide?
Plenty of supplements coexist fine with Nateglinide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Starlix have the same supplement interactions as Nateglinide?
Yes — Starlix all contain Nateglinide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nateglinide deplete any vitamins or nutrients?
It might — Nateglinide has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nateglinide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nateglinide and my other medications?
This page covers Nateglinide against supplements and herbal ingredients. Checking Nateglinide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Nateglinide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.