Herb & supplement monograph

Coriander Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Coriander interacts with medications. The heart of this page is the interaction list — every drug Coriander is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Coriander is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Coriander Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Coriander drug interaction appears low for most people. None of the listed interactions are rated major, and every one is theoretical, drawn from animal or lab research rather than studies in people.

Interactions deserving the most attention

The combinations most worth watching involve diabetes medications and blood pressure medications. Animal research suggests coriander may lower blood sugar and blood pressure, so in theory it could add to the effects of these closely monitored medicines and cause levels to dip too low. Coriander extract has also shown sedative effects in animals, which could in theory add to the drowsiness caused by sedating medications. To be clear, none of these effects have been confirmed in humans.

What the rest of the list means

The long list of interacting medications reflects a handful of broad drug categories, not hundreds of proven problems. Each concern comes from animal or lab findings that predict what coriander might do, and none has been shown to cause meaningful changes in people. For most, this is a reason for simple awareness rather than worry.

Check your medications against Coriander

Based on HelloPharmacist’s Coriander interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Coriander

717 medications have a known interaction with Coriander, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Coriander using our pharmacist-reviewed interaction data.

AI summaries are generated from our Coriander interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Coriander combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Coriander affects

Every type of medication (drug category) Coriander is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 4 drug categories Coriander interacts with

Antidiabetes DrugsAntihypertensive DrugsCns DepressantsPhotosensitizing Drugs

Antidiabetes Drugs

Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Evidence from animal research suggests that coriander fruit and coriander extract can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D

Antihypertensive Drugs

Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Evidence from animal research suggests that coriander fruit can lower blood pressure.

Likelihood Possible Evidence D

Cns Depressants

Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Evidence from animal research suggests that coriander fruit extract has sedative effects.

Likelihood Possible Evidence D

Photosensitizing Drugs

Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Evidence from in vitro research suggests that coriandrin, a constituent of coriander, has photosensitizing effects.

Likelihood Possible Evidence D

Monograph

Coriander: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints. As a food it is generally safe for most people, but high-quality human studies supporting its medicinal benefits are limited. Talk with your pharmacist or doctor before using concentrated extracts or essential oils.

Scientific name: Coriandrum sativum
Family: Apiaceae
Part used: Seeds (fruit), leaves, and essential oil
Common forms: Culinary spice and herb, tea, capsules, tincture/extract, essential oil

People commonly use it for

Digestive upset and gas
Appetite stimulation
Mild antimicrobial (topical)
Diarrhea and IBS symptoms
General flavoring and traditional remedy

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallLikely safe

Coriander is generally safe in normal food amounts for most people.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid amounts in excess of those found in foods.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid amounts in excess of those found in foods.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Coriander comes from the plant Coriandrum sativum, a member of the parsley (Apiaceae) family. The same plant gives us two familiar ingredients: the dried seeds (often called coriander) and the fresh leaves (often called cilantro). It is native to the Mediterranean region and is now grown around the world.

People have used coriander for thousands of years as both a food and a folk remedy. In cooking it adds flavor to many dishes. In traditional medicine, the seeds and leaves have most often been used for stomach and digestive complaints, while the essential oil has been studied for possible germ-fighting effects.

How it works

Coriander contains a mix of plant compounds, including essential oils (such as linalool), flavonoids, and other antioxidants. These substances are thought to give coriander its flavor and its possible effects.

Researchers believe coriander may relax the muscles of the gut, which could ease cramping and gas, and may have mild antioxidant and antimicrobial actions. It is important to know that most of these ideas are based on laboratory and animal research, not large human studies, so the real-world effects in people are not well proven.

Effectiveness

Does Coriander work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 16 uses evaluated

16 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Coriander, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 16 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Anorexia