Herb & supplement monograph

Resveratrol Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Resveratrol interacts with medications. The heart of this page is the interaction list — every drug Resveratrol is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Resveratrol is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Resveratrol Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Resveratrol drug interaction appears low for most people, though a few combinations deserve real attention. All of the listed interactions are rated moderate rather than major, and most rest on lab research rather than proof in people.

Interactions deserving the most attention

The best-documented concern involves medications cleared by an enzyme called CYP2E1, since a human study found that resveratrol raised blood levels of the muscle relaxant chlorzoxazone by more than half. We also give weight to anticoagulant and antiplatelet drugs, because resveratrol seems to have blood-thinning effects of its own and could add to bleeding risk. These matter most for medicines where a small change in effect can be meaningful.

What the rest of the list means

The long list of interacting medications reflects resveratrol's possible effects on several enzymes the body uses to clear drugs, and most of these predictions come from lab studies only. In fact, human research on one major enzyme pathway found that high-dose resveratrol did not require any medication dose changes, so many of the listed combinations may never cause a real problem.

Check your medications against Resveratrol

Based on HelloPharmacist’s Resveratrol interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Resveratrol

824 medications have a known interaction with Resveratrol, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Resveratrol using our pharmacist-reviewed interaction data.

AI summaries are generated from our Resveratrol interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Resveratrol combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Resveratrol affects

Every type of medication (drug category) Resveratrol is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Resveratrol interacts with

Anticoagulant/antiplatelet DrugsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2e1 (cyp2e1) SubstratesCytochrome P450 3a4 (cyp3a4) Substrates

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D

Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D

Monograph

Resveratrol: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, strong human evidence for most uses is still limited. It appears generally well tolerated in supplement doses, but talk with your pharmacist or doctor before starting it.

Part used: A plant compound found in grape skins, berries, peanuts, and Japanese knotweed
Common forms: Capsules, tablets, softgels, powders

People commonly use it for

Heart and blood vessel health
Antioxidant support
Anti-aging
Blood sugar and metabolic support
General anti-inflammatory support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Generally well tolerated in typical supplement doses, but high doses may cause digestive upset and long-term safety is not fully known.

PregnancyLikely Safe

When used in amounts found in foods. Resveratrol is found in grape skins, grape juice, wine, and other food sources. However, wine should not be used...

Read the full pregnancy detail

BreastfeedingLikely Safe

When used in amounts found in foods. Resveratrol is found in grape skins, grape juice, wine, and other food sources. However, wine should not be used...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Resveratrol is a natural compound made by certain plants when they are stressed or attacked by germs. It is part of a group of plant chemicals sometimes called phytoalexins. You can find it in the skins of red grapes, in berries like blueberries and cranberries, in peanuts, and in a plant called Japanese knotweed, which is a common source for supplements.

Resveratrol became well known because it is found in red wine, and some people connected it to the idea that moderate red wine drinking might be good for the heart. Today it is sold as a dietary supplement in capsules, tablets, and powders. People take it hoping to support heart health, slow aging, and get antioxidant benefits.

How it works

Resveratrol is a polyphenol, a type of plant chemical that can act as an antioxidant. Antioxidants may help protect cells from damage caused by unstable molecules called free radicals.

In laboratory studies, resveratrol has been shown to affect several body pathways. It may influence proteins called sirtuins that are involved in cell aging, reduce inflammation signals, and affect how blood vessels relax. Some research also looks at its effects on blood sugar handling and fat metabolism.

It is important to know that most of these mechanisms come from cell and animal research. Resveratrol is also poorly absorbed and broken down quickly by the body, so the high amounts used in lab studies may be hard to reach in people taking supplements.

Effectiveness

Does Resveratrol work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 30 uses evaluated

2 Possibly effective 4 Leans ineffective 24 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

Possibly Effective Allergic rhinitis (hay fever)