Medication interaction hub

What Supplements Interact with Acetaminophen, Caffeine, Codeine?

Acetaminophen, Caffeine, Codeine brand names: Gesic C8, Gesic C15, Lenoltec 2, Gesic C30, Lenoltec 3, and others. Every interaction below applies to the brands too.

303 Interactions 15 Major 244 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Caffeine, Codeine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Caffeine, Codeine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

303 supplements and herbal ingredients have interactions with Acetaminophen, Caffeine, Codeine on file in the HelloPharmacist interaction database — 15 rated major, 244 moderate, and 44 minor. The most serious involve Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol.

Our assessment: with 15 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Acetaminophen, Caffeine, Codeine.

Major 15 Moderate 244 Minor 44 No known interaction 1,149

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Caffeine, Codeine: Top Interactions at a Glance

The Acetaminophen, Caffeine, Codeine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 303 interacting ingredients — plus 1,149 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Caffeine, Codeine Combinations Today

The Acetaminophen, Caffeine, Codeine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Melatonin + Acetaminophen, Caffeine, Codeinei

Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Possible Bacopa + Acetaminophen, Caffeine, Codeinei

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Astaxanthin + Acetaminophen, Caffeine, Codeinei

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Probable Black Tea + Acetaminophen, Caffeine, Codeinei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Acetaminophen, Caffeine, Codeinei

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Aristolochia + Acetaminophen, Caffeine, Codeinei

Aristolochia is nephrotoxic.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Caffeine, Codeine

All 1,452 ingredients in our database, ranked by severity — 303 with a Acetaminophen, Caffeine, Codeine interaction on file and 1,149 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Caffeine, Codeine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Melatonin with Acetaminophen, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.

Full Melatonin + Acetaminophen, Caffeine, Codeine answer

Can you take Bacopa with Acetaminophen, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.

Full Bacopa + Acetaminophen, Caffeine, Codeine answer

Can you take Astaxanthin with Acetaminophen, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Acetaminophen, Caffeine, Codeine answer

Can you take Black Tea with Acetaminophen, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Acetaminophen, Caffeine, Codeine answer

Can you take Ashwagandha with Acetaminophen, Caffeine, Codeine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Acetaminophen, Caffeine, Codeine answer

Can you take Tyramine with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking tyramine with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Tyramine + Acetaminophen, Caffeine, Codeine answer

Can you take Vitamin D with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Acetaminophen, Caffeine, Codeine answer

Can you take Xanthan Gum with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Acetaminophen, Caffeine, Codeine answer

Can you take Asian Water Plantain with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Acetaminophen, Caffeine, Codeine answer

Can you take Calendula with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.

Full Calendula + Acetaminophen, Caffeine, Codeine answer

Can you take Chrysin with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.

Full Chrysin + Acetaminophen, Caffeine, Codeine answer

Can you take Diindolylmethane with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.

Full Diindolylmethane + Acetaminophen, Caffeine, Codeine answer

Can you take Gamma-aminobutyric Acid (gaba) with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Full Gamma-aminobutyric Acid (gaba) + Acetaminophen, Caffeine, Codeine answer

Can you take Humann Superbeets Heart Chews with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Acetaminophen, Caffeine, Codeine answer

Can you take Jequirity with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Acetaminophen, Caffeine, Codeine answer

Can you take Mommy's Bliss Gripe Water with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Acetaminophen, Caffeine, Codeine answer

Can you take Polypodium Leucotomos with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Acetaminophen, Caffeine, Codeine answer

Can you take Red Clover with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.

Full Red Clover + Acetaminophen, Caffeine, Codeine answer

Can you take Rosemary with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.

Full Rosemary + Acetaminophen, Caffeine, Codeine answer

Can you take Tangerine with Acetaminophen, Caffeine, Codeine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Acetaminophen, Caffeine, Codeine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Caffeine, Codeine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Caffeine, Codeine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Caffeine, Codeine sits in 17 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Codeine through this category.

Codeine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Caffeine, Codeine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Caffeine, Codeine through this category.

Related: does Acetaminophen, Caffeine, Codeine deplete any nutrients?

Acetaminophen, Caffeine, Codeine has 14 reported nutrient associations in the research literature — see the Acetaminophen, Caffeine, Codeine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Caffeine, Codeine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Caffeine, Codeine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Acetaminophen, Caffeine, Codeine & Supplements: Common Questions

What supplements interact with Acetaminophen, Caffeine, Codeine?
Our database currently documents 303 ingredients with a known Acetaminophen, Caffeine, Codeine interaction (15 major, 244 moderate, 44 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 303. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Acetaminophen, Caffeine, Codeine supplement interactions are the most serious?
The 15 major-rated combinations — led by Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Caffeine, Codeine?
Plenty of supplements coexist fine with Acetaminophen, Caffeine, Codeine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Gesic C8 have the same supplement interactions as Acetaminophen, Caffeine, Codeine?
Yes — Gesic C8, Gesic C15, Lenoltec 2, Gesic C30, Lenoltec 3 and other brands all contain Acetaminophen, Caffeine, Codeine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Caffeine, Codeine deplete any vitamins or nutrients?
It might — Acetaminophen, Caffeine, Codeine has 14 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Caffeine, Codeine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Caffeine, Codeine and my other medications?
This page covers Acetaminophen, Caffeine, Codeine against supplements and herbal ingredients. Checking Acetaminophen, Caffeine, Codeine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.