Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Timolol?

Hydrochlorothiazide, Timolol brand name: Timolide. Every interaction below applies to the brands too.

276 Interactions 11 Major 234 Moderate 31 Minor
Curated & coded by · Clinical Pharmacist · Updated September 29, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Timolol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Timolol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

276 supplements and herbal ingredients have interactions with Hydrochlorothiazide, Timolol on file in the HelloPharmacist interaction database — 11 rated major, 234 moderate, and 31 minor. The most serious involve American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe.

Our assessment: with 11 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Hydrochlorothiazide, Timolol.

Major 11 Moderate 234 Minor 31 No known interaction 1,176

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Hydrochlorothiazide, Timolol: Top Interactions at a Glance

The most significant Hydrochlorothiazide, Timolol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 276 interacting ingredients — plus 1,176 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Hydrochlorothiazide, Timolol + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Hydrochlorothiazide, Timololi

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Hydrochlorothiazide, Timololi

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Likely Tyramine + Hydrochlorothiazide, Timololi

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Hydrochlorothiazide, Timololi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Hydrochlorothiazide, Timololi

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Dolomite + Hydrochlorothiazide, Timololi

Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Timolol

All 1,452 ingredients in our database, ranked by severity — 276 with a Hydrochlorothiazide, Timolol interaction on file and 1,176 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Timolol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Quercetin with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.

Full Quercetin + Hydrochlorothiazide, Timolol answer

Can you take Hordenine with Hydrochlorothiazide, Timolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full Hordenine + Hydrochlorothiazide, Timolol answer

Can you take Slippery Elm with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Hydrochlorothiazide, Timolol answer

Can you take Sodium Bicarbonate with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking thiazide diuretics.

Full Sodium Bicarbonate + Hydrochlorothiazide, Timolol answer

Can you take Soy with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Full Soy + Hydrochlorothiazide, Timolol answer

Can you take Squill with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Squill contains cardiac glycosides.

Full Squill + Hydrochlorothiazide, Timolol answer

Can you take St. John's Wort with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Hydrochlorothiazide, Timolol answer

Can you take Star Of Bethlehem with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.

Full Star Of Bethlehem + Hydrochlorothiazide, Timolol answer

Can you take Stinging Nettle with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Full Stinging Nettle + Hydrochlorothiazide, Timolol answer

Can you take Strophanthus with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and strophanthus can increase the risk of cardiac glycoside toxicity due to...

Full Strophanthus + Hydrochlorothiazide, Timolol answer

Can you take Swamp Milkweed with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, potassium depleting diuretics might increase the risk of toxicity with swamp milkweed.

Full Swamp Milkweed + Hydrochlorothiazide, Timolol answer

Can you take Terminalia with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Hydrochlorothiazide, Timolol answer

Can you take Theanine with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Full Theanine + Hydrochlorothiazide, Timolol answer

Can you take Thuja with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Hydrochlorothiazide, Timolol answer

Can you take Tinospora Cordifolia with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Full Tinospora Cordifolia + Hydrochlorothiazide, Timolol answer

Can you take Tragacanth with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Hydrochlorothiazide, Timolol answer

Can you take Tree Turmeric with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Tree Turmeric + Hydrochlorothiazide, Timolol answer

Can you take Tribulus with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Hydrochlorothiazide, Timolol answer

Can you take Uzara with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassi...

Full Uzara + Hydrochlorothiazide, Timolol answer

Can you take Vitamin B6 with Hydrochlorothiazide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Hydrochlorothiazide, Timolol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Timolol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Timolol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Timolol sits in 11 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Timolol through this category.

Related: does Hydrochlorothiazide, Timolol deplete any nutrients?

Hydrochlorothiazide, Timolol has 10 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Timolol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Timolol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Timolol.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Timolol & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Timolol?
Our database currently documents 276 ingredients with a known Hydrochlorothiazide, Timolol interaction (11 major, 234 moderate, 31 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 276. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Timolol supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Timolol?
Plenty of supplements coexist fine with Hydrochlorothiazide, Timolol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Timolide have the same supplement interactions as Hydrochlorothiazide, Timolol?
Yes — Timolide all contain Hydrochlorothiazide, Timolol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Timolol deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Timolol has 10 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Timolol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Timolol and my other medications?
This page covers Hydrochlorothiazide, Timolol against supplements and herbal ingredients. Checking Hydrochlorothiazide, Timolol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 29, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.