Modafinil

59 interactions 3 explained in plain English
Also sold as: Provigil
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Modafinil Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Modafinil Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Modafinil Atogepant Qulipta Reduced atogepant exposure Details Modafinil Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Modafinil Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Modafinil Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Modafinil Amlodipine Amvaz® Reduced amLODIPine exposure Details Modafinil Axitinib Inlyta Reduced axitinib exposure Details Modafinil Bedaquiline Sirturo Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Modafinil Brigatinib Alunbrig Decreased brigatinib exposure and efficacy Details Modafinil Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Modafinil Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Modafinil Capmatinib Tabrecta Decreased capmatinib exposure and reduction of antitumor activity Details Modafinil Cobimetinib Cotellic Decreased cobimetinib plasma concentrations Details Modafinil Cyclosporine Injection Atopica Reduced cycloSPORINE exposure and reduced efficacy of cycloSPORINE Details Modafinil Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure and reduced efficacy of cycloSPORINE Details Modafinil Deflazacort Emflaza Decreased exposure to active metabolite of deflazacort Details Modafinil Doravirine Pifeltro Reduced doravirine exposure and reduced efficacy of doravirine Details Modafinil Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Modafinil Elacestrant Orserdu Reduced elacestrant exposure and reduced efficacy of elacestrant Details Modafinil Encorafenib Braftovi Reduced encorafenib exposure and reduced efficacy of encorafenib Details Modafinil Entrectinib Rozlytrek Reduced entrectinib exposure and reduced efficacy of entrectinib Details Modafinil Erdafitinib Balversa Reduced erdafitinib exposure Details Modafinil Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Modafinil Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Modafinil Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Modafinil Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Modafinil Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Modafinil Glasdegib Daurismo Reduced glasdegib exposure Details Modafinil Ibrexafungerp Brexafemme Decreased ibrexafungerp plasma concentrations Details Modafinil Ifosfamide Injection Ifex Increased neurotoxic and nephrotoxic effects Details Modafinil Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Modafinil Lefamulin Xenleta Reduced lefamulin exposure and reduced efficacy of lefamulin Details Modafinil Lenacapavir Injection Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Modafinil Lenacapavir Oral Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Modafinil Leniolisib Joenja Reduced leniolisib exposure and reduced efficacy of leniolisib Details Modafinil Letermovir Injection Prevymis Reduced letermovir exposure and reduced efficacy of letermovir Details Modafinil Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Modafinil Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Modafinil Lumateperone Caplyta Reduced lumateperone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.