Nortriptyline

82 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Nortriptyline Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Nortriptyline Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Nortriptyline Sertraline Explained Increased nortriptyline exposure and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status... Details Nortriptyline Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Nortriptyline Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Nortriptyline Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nortriptyline Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nortriptyline Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Nortriptyline Aspirin Acuprin® An increased risk of bleeding Details Nortriptyline Aspirin Rectal Aspirin An increased risk of bleeding Details Nortriptyline Azathioprine Azasan An increased risk of hepatotoxicity Details Nortriptyline Azithromycin AzaSite An increased risk of QT interval prolongation Details Nortriptyline Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Nortriptyline Alfuzosin UroXatral An increased risk of QT interval prolongation Details Nortriptyline Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Nortriptyline Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Nortriptyline Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Nortriptyline Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nortriptyline Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Nortriptyline Dacomitinib Vizimpro Increased exposure of the CYP2D6 substrate Details Nortriptyline Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Nortriptyline Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Nortriptyline Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Nortriptyline Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Nortriptyline Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nortriptyline Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nortriptyline Dolasetron Anzemet Increased risk of serotonin syndrome Details Nortriptyline Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Nortriptyline Etodolac Lodine An increased risk of bleeding Details Nortriptyline Fenoprofen Fenopron An increased risk of bleeding Details Nortriptyline Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Nortriptyline Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nortriptyline Flurbiprofen Ansaid An increased risk of bleeding Details Nortriptyline Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Nortriptyline Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nortriptyline Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Nortriptyline Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.