Herb & supplement monograph

Tribulus Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Tribulus interacts with medications. The heart of this page is the interaction list — every drug Tribulus is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Tribulus is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Tribulus Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Tribulus drug interaction appears low for most people, though those taking a few closely-monitored medicines should be more careful. None of the listed interactions are rated major, and most rest on limited or theoretical evidence rather than well-controlled human studies.

Interactions deserving the most attention

The best-supported concern involves diabetes medications, since clinical research shows Tribulus can lower blood sugar in adults with type 2 diabetes, which could add to the effect of their medication and raise the chance of low blood sugar. Lithium also deserves attention because Tribulus may act as a mild diuretic, which could reduce how the body clears lithium and raise its levels, and lithium has a narrow safety margin. Tribulus has also lowered blood pressure in some studies, so people on blood pressure medications should watch for added effects like dizziness.

What the rest of the list means

The long list of interacting medications largely reflects a few broad categories, such as the many different diabetes and blood pressure drugs, rather than hundreds of separate proven problems. Much of the concern comes from animal research or predicted effects, and these have not been confirmed as clinically meaningful in people for most combinations.

Check your medications against Tribulus

Based on HelloPharmacist’s Tribulus interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Tribulus

259 medications have a known interaction with Tribulus, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Tribulus + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcebutololRhotral, Sectral
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Acebutolol interaction Acebutolol drug page: uses, dosage & side effects
AcetazolamideAk-Zol, Diamox
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Acetazolamide interaction Acetazolamide drug page: uses, dosage & side effects
AcetohexamideDymelor
Moderate Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Tribulus + Acetohexamide interaction
AlbiglutideTanzeum
Moderate Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Tribulus + Albiglutide interaction
AliskirenTekturna
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Aliskiren interaction Aliskiren drug page: uses, dosage & side effects
AlogliptinNesina
Moderate Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Tribulus + Alogliptin interaction Alogliptin drug page: uses, dosage & side effects
Alogliptin, MetforminKazano
Moderate Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Tribulus + Alogliptin, Metformin interaction
Alogliptin, PioglitazoneOseni
Moderate Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Tribulus + Alogliptin, Pioglitazone interaction
AmbrisentanLetairis, Volibris
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Ambrisentan interaction Ambrisentan drug page: uses, dosage & side effects
AmilorideAmilamont, Midamor
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Amiloride interaction Amiloride drug page: uses, dosage & side effects
Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Amiloride, Hydrochlorothiazide interaction Amiloride, Hydrochlorothiazide drug page: uses, dosage & side effects
AmlodipineNorliqva
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Amlodipine interaction Amlodipine drug page: uses, dosage & side effects
Amlodipine BenzoateKaterzia
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Amlodipine Benzoate interaction Amlodipine Benzoate drug page: uses, dosage & side effects
Amlodipine BesilateIstin
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Amlodipine Besilate interaction
Amlodipine BesylateNorvasc
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Amlodipine Besylate interaction Amlodipine Besylate drug page: uses, dosage & side effects
Amlodipine Besylate, BenazeprilLotrel
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Amlodipine Besylate, Benazepril interaction
Amlodipine, CelecoxibConsensi
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Amlodipine, Celecoxib interaction
Ammonium ChlorideAmmonium Chloride
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Ammonium Chloride interaction
Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Moderate Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Tribulus + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interaction
AprocitentanTryvio
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Aprocitentan interaction Aprocitentan drug page: uses, dosage & side effects
AtenololAtenix, Tenormin
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Atenolol interaction Atenolol drug page: uses, dosage & side effects
Atenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Atenolol, Chlortalidone interaction
Atenolol, ChlorthalidoneTenoretic
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Atenolol, Chlorthalidone interaction
AzilsartanEdarbi
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Azilsartan interaction Azilsartan drug page: uses, dosage & side effects
Azilsartan, ChlorthalidoneEdarbyclor
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Azilsartan, Chlorthalidone interaction
BenazeprilLotensin
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Benazepril interaction Benazepril drug page: uses, dosage & side effects
Benazepril, HydrochlorothiazideLotensin HCT
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Benazepril, Hydrochlorothiazide interaction
BendroflumethiazideAprinox, Naturetin, Neo-NaClex
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Bendroflumethiazide interaction
Bendroflumethiazide, NadololCorzide
Moderate Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full Tribulus + Bendroflumethiazide, Nadolol interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Tribulus combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Tribulus affects

Every type of medication (drug category) Tribulus is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories Tribulus interacts with
Antidiabetes DrugsAntihypertensive DrugsLithium
Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Monograph

Tribulus: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is generally well tolerated by healthy adults in the short term, but it should be avoided during pregnancy and breastfeeding and discussed with your pharmacist or doctor before use.

Tribulus
Scientific name
Tribulus terrestris
Family
Zygophyllaceae
Part used
Fruit, leaf, and root
Common forms
Capsules, tablets, powders, tinctures, and standardized extracts
People commonly use it for
  • Low libido and sexual function
  • Athletic performance and muscle building
  • Testosterone support
  • Male and female fertility
  • General 'vitality' or wellness

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Often well tolerated short-term in healthy adults, but quality and long-term safety data are limited.

PregnancyPossibly Unsafe

When used orally. Animal research suggests that tribulus might adversely affect fetal development; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Tribulus (Tribulus terrestris) is a low-growing plant that produces small yellow flowers and spiky, hard fruit. Because of its sharp burrs it is sometimes called caltrop, puncture vine, or bindii. It grows in many warm and tropical parts of the world, including Africa, Asia, southern Europe, and Australia.

The plant has a long history in traditional medicine systems, including Ayurveda and traditional Chinese medicine. Today the fruit, leaf, and root are dried and made into capsules, tablets, powders, and liquid extracts. It is one of the most widely sold ingredients in supplements marketed for sexual health and sports performance.

How it works

Tribulus contains a mix of plant compounds, including steroidal saponins such as protodioscin, as well as flavonoids and alkaloids. Protodioscin is the compound most often credited with the plant's possible effects.

Researchers have proposed that these saponins may influence hormones such as testosterone and DHEA, or that they may affect blood flow and nitric oxide pathways that play a role in sexual function. However, much of this is based on laboratory and animal studies, and the findings have not been clearly confirmed in well-designed human trials.

Effectiveness

Does Tribulus work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 20 uses evaluated
1 Possibly effective 1 Leans ineffective 18 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Sexual dysfunction
Rating & evidence shown verbatim from Natural Medicines

Oral tribulus seems to improve sexual experience in females with hypoactive sexual desire disorder (HSDD) or sexual dysfunction. Some research also shows that oral tribulus improves sexual function in males.

Possibly Ineffective Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Oral tribulus does not seem to improve athletic performance.

Also studied for 18 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Angina
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tribulus is beneficial for angina.

Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

Oral tribulus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Bacterial vaginosis
Rating & evidence shown verbatim from Natural Medicines

Topical tribulus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Benign prostatic hyperplasia (BPH)
Rating & evidence shown verbatim from Natural Medicines

Oral tribulus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral tribulus for cancer, there is insufficient reliable information about the clinical effects of tribulus for this condition.

Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral tribulus for CFS, there is insufficient reliable information about the clinical effects of tribulus for this condition.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tribulus is beneficial for diabetes.

Insufficient Reliable Evidence To Rate Erectile dysfunction (ED)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tribulus is beneficial for ED. Research is conflicting.

Insufficient Reliable Evidence To Rate Exercise-induced muscle damage
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tribulus is beneficial for exercise-induced muscle damage.

Insufficient Reliable Evidence To Rate Gonorrhea
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral tribulus for gonorrhea, there is insufficient reliable information about the clinical effects of tribulus for this condition.

Insufficient Reliable Evidence To Rate Hypercholesterolemia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral tribulus for hypercholesterolemia, there is insufficient reliable information about the clinical effects of tribulus for this condition.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tribulus can lower blood pressure.

Insufficient Reliable Evidence To Rate Kidney stones (nephrolithiasis)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral tribulus for kidney stones, there is insufficient reliable information about the clinical effects of tribulus for this purpose.

Insufficient Reliable Evidence To Rate Male infertility
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral tribulus is beneficial for male infertility; the available research is conflicting.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

Oral tribulus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Osteoporosis
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral tribulus for osteoporosis, there is insufficient reliable information about the clinical effects of tribulus for this condition.

Insufficient Reliable Evidence To Rate Polycystic ovary syndrome (PCOS)
Rating & evidence shown verbatim from Natural Medicines

Oral tribulus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Premature ejaculation
Rating & evidence shown verbatim from Natural Medicines

Oral tribulus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most healthy adults, Tribulus appears to be reasonably well tolerated when used by mouth for a short time. Still, high-quality long-term safety data are limited, and supplement quality can vary widely between brands.

People with hormone-sensitive conditions, prostate problems, diabetes, or kidney or liver disease should be cautious and talk to a healthcare provider first, since Tribulus may affect hormones and other body systems. There have been rare reports of liver or kidney problems linked to products containing Tribulus, so stop use and seek care if you feel unwell.

Pregnancy and breastfeeding: Avoid Tribulus if you are pregnant, because it may affect hormones and may not be safe for a developing baby. Avoid it while breastfeeding as well, since there is not enough reliable information to consider it safe.

Side effects

When side effects occur, they are most often mild and may include stomach upset, cramping, nausea, or diarrhea. Some people report restlessness or trouble sleeping.

More serious problems are rare but have been reported, including cases of liver injury and kidney issues with certain Tribulus-containing products. Some animal studies have raised concerns about effects on the heart or sperm at high doses. Seek medical care if you develop yellowing of the skin or eyes, severe abdominal pain, dark urine, or other unexpected symptoms.

Tribulus: Reported Adverse Effects

Documented safety reports on Tribulus from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, tribulus seems to be well tolerated.

Serious Adverse Effects (Rare):

Orally: Cases of liver and kidney injury, seizures, and chronic painful erection with impaired sexual function have been reported. Pneumothorax and bronchial polyp after consuming the spine-covered tribulus fruit have been reported.

Reports by condition
Constipation Gastrointestinal

Orally, tribulus can cause abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation. However, in one study, the rates of these gastrointestinal complaints were similar for patients taking tribulus and those receiving placebo.

  1. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40.
  2. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6.
Epilepsy Hepatic

In one case report, a patient drinking tribulus water 2 liters daily for two days presented with lower limb weakness, seizures, hepatitis, and acute kidney injury. The patient's condition improved after hemodialysis and discontinuation of tribulus water.

  1. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3.
Epilepsy Renal

In one case report, a patient drinking tribulus water 2 liters daily for two days presented with lower limb weakness, seizures, hepatitis, and acute kidney injury. The patient's condition improved after hemodialysis and discontinuation of the tribulus water. In another case report, a healthy male taking one tribulus tablet (unknown dose) daily for a few months for bodybuilding purposes developed hyperbilirubinemia followed by acute kidney failure 2-3 weeks later. The patient was managed with intravenous fluids and a low-salt, low-protein diet.

  1. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3.
  2. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83.
Epilepsy Neurologic/CNS

Orally, tribulus has been reported to cause general excitation and insomnia. These symptoms were reversed upon discontinuation of the drug or decreasing the dose. In one case report, a patient drinking tribulus water 2 liters daily for two days presented with lower limb weakness, seizures, hepatitis, and acute kidney injury. The patient's condition improved after hemodialysis and discontinuation of tribulus water.

  1. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  2. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established standard dose for Tribulus. Studies have used a range of doses and different extracts, often standardized to a percentage of saponins, which makes it hard to compare products or recommend one amount.

The best approach is to follow the directions on the specific product label and not exceed them. Because strength and quality vary between brands, check with your pharmacist or doctor before starting Tribulus, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Tribulus & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 10 references that drive our Tribulus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Tribulus

573 brands in our database make a supplement containing Tribulus.

Product directory

Supplement products with Tribulus

1,756 products in our database contain Tribulus. Open any to see its full ingredient list and every drug interaction we check.

100% Pure Tribulus by NutraBio Powder 500 Gram(s) · 1.1 lbs View ingredients & interactions 100% Pure Tribulus by NutraBio Powder 150 Gram(s) · 5.3 Ounce(s) View ingredients & interactions 100% Pure Tribulus 500 Milligrams by NutraBio Capsule 500 V-Cap(s) View ingredients & interactions 100% Tribulus by Evlution Nutrition Capsule 60 Veggie Capsule(s) View ingredients & interactions 12 Hour X-Treme by BioXgenic Capsule 180 Liquid Capsule(s) View ingredients & interactions 17-Beta by iSatori Capsule 90 Capsule(s) View ingredients & interactions 3-Test-OXO by Legal Limit Labs Capsule 90 Capsule(s) View ingredients & interactions 7-Herb Energy by Banyan Botanicals Liquid 1 fl. Oz. · 30 mL View ingredients & interactions A-D-T 100 by Red Label Capsule View ingredients & interactions Action Max For Men by Country Life Tablet Or Pill 60 Tablet(s) View ingredients & interactions Action Max For Men by Country Life Tablet Or Pill 120 Tablet(s) View ingredients & interactions Action Max For Men Xxxtreme by Country Life Tablet Or Pill 60 Tablet(s) View ingredients & interactions Active Man's Formula by Vitabase Tablet Or Pill 90 Tablet(s) View ingredients & interactions ActiVit Body Toning Formula by Beachbody Nutritionals Tablet Or Pill 60 Tablet(s) View ingredients & interactions Adam's Virility by Logos Nutritionals Capsule 60 Capsule(s) View ingredients & interactions Adrenal Nourish by Banyan Botanicals Tablet Or Pill 90 Tablet(s) View ingredients & interactions Adrenal Support by Bel-Air Nutrition Corp Capsule 90 Veggie Capsule(s) View ingredients & interactions Advanced BP by New Sun Capsule 90 Vegetarian Capsules View ingredients & interactions Advanced BP by New Sun Capsule 90 Vegetarian Capsules View ingredients & interactions Advanced Men's Formula by Roex Capsule 90 Capsule(s) View ingredients & interactions Advanced Testosterone by GNC Men's Capsule 60 Capsule(s) View ingredients & interactions Alpha 365 by Glaxon Capsule 120 Capsule(s) View ingredients & interactions Alpha Energy by Chemical Free Body Capsule 90 Capsule(s) View ingredients & interactions Alpha Fuel XT by Science of Alpha Capsule 60 Veggie Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Tribulus: Common Questions

What is Tribulus used for, and does it work?
People use Tribulus for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Tribulus for Sexual dysfunction. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Tribulus interact with prescription medications?
Yes. We list 259 medications with a known interaction with Tribulus. Use the checker above to see how Tribulus interacts with a specific drug.
How are Tribulus interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Tribulus with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Tribulus interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Does Tribulus actually raise testosterone?
In most studies of healthy men, Tribulus has not meaningfully increased testosterone levels. The evidence for this popular claim is weak and inconsistent.
Can Tribulus improve sex drive?
Some small studies suggest a possible modest benefit for libido in certain people, but results are mixed and the overall evidence is not strong enough to promise it works.
Is Tribulus safe to take?
It is generally well tolerated by healthy adults for short periods, but long-term safety data are limited and rare liver or kidney problems have been reported. Check with your pharmacist or doctor first.
Can I take Tribulus while pregnant or breastfeeding?
No. It is best to avoid Tribulus during pregnancy and breastfeeding because it may affect hormones and its safety has not been established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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