Medication interaction hub

What Supplements Interact with Insulin Degludec?

Insulin Degludec brand name: Tresiba. Every interaction below applies to the brands too.

239 Interactions 1 Major 208 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin Degludec? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin Degludec against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Insulin degludec (Tresiba) is a long-acting insulin meant to hold blood sugar steady around the clock, which means anything else that pushes glucose down can push it too far. That is the story for nearly all 239 ingredients on this page, and the list warrants genuine caution. The single major-rated entry, Siberian cocklebur, has caused severe hypoglycemia in humans and has no place alongside insulin.

The 208 moderate entries are mostly herbs and nutrients that add their own smaller glucose-lowering nudge, and combining several stacks that effect. A few work in reverse; niacin can raise blood sugar and blunt what your insulin dose accomplishes, while the alcohol and carbohydrates in beer can pull control in both directions at once. The remaining 30 minor entries echo the same themes with less force, but even a mild push matters when insulin is doing the heavy lifting.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 208 Minor 30 No known interaction 1,213

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Insulin Degludec: Top Interactions at a Glance

The Insulin Degludec supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 239 interacting ingredients — plus 1,213 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Insulin Degludec Combinations Today

The Insulin Degludec + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Colocynth + Insulin Degludeci

Theoretically, colocynth might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Elderflower + Insulin Degludeci

Theoretically, elderflower might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Black Mustard + Insulin Degludeci

Theoretically, black mustard seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Kombucha + Insulin Degludeci

Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Black Mulberry + Insulin Degludeci

Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Jiaogulan + Insulin Degludeci

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin Degludec

All 1,452 ingredients in our database, ranked by severity — 239 with a Insulin Degludec interaction on file and 1,213 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin Degludec?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Colocynth with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, colocynth might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Colocynth + Insulin Degludec answer

Can you take Elderflower with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elderflower might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Elderflower + Insulin Degludec answer

Can you take Black Mustard with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black mustard seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Black Mustard + Insulin Degludec answer

Can you take Kombucha with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Kombucha + Insulin Degludec answer

Can you take Black Mulberry with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Black Mulberry + Insulin Degludec answer

Can you take Gymnema with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.

Full Gymnema + Insulin Degludec answer

Can you take Inositol Nicotinate with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Full Inositol Nicotinate + Insulin Degludec answer

Can you take Ivy Gourd with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Full Ivy Gourd + Insulin Degludec answer

Can you take Niacin with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Full Niacin + Insulin Degludec answer

Can you take Panax Ginseng with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Full Panax Ginseng + Insulin Degludec answer

Can you take Papaya with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.

Full Papaya + Insulin Degludec answer

Can you take Prickly Pear Cactus with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Prickly Pear Cactus + Insulin Degludec answer

Can you take Ribose with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ribose + Insulin Degludec answer

Can you take Salacia with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Salacia + Insulin Degludec answer

Can you take Sida Cordifolia with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Sida cordifolia might reduce the effectiveness of antidiabetes drugs.

Full Sida Cordifolia + Insulin Degludec answer

Can you take Tree Turmeric with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking an...

Full Tree Turmeric + Insulin Degludec answer

Can you take Vanadium with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Vanadium + Insulin Degludec answer

Can you take Wine with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Wine + Insulin Degludec answer

Can you take Acai with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Full Acai + Insulin Degludec answer

Can you take African Wild Potato with Insulin Degludec?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that African wild potato lowers blood glucose levels.

Full African Wild Potato + Insulin Degludec answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin Degludec is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin Degludec, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin Degludec sits in 1 interaction category. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin Degludec through this category.

About Insulin Degludec

Insulin degludec is a long-acting insulin analog used to improve blood sugar control in adults and children 1 year and older with type 1 or type 2 diabetes mellitus.

Generic name: Insulin Degludec  ·  Brand name: Tresiba.

See the full Insulin Degludec (rDNA Origin) Injection drug information

Related: does Insulin Degludec deplete any nutrients?

Insulin Degludec has 1 reported nutrient association in the research literature — see the Insulin Degludec nutrient depletion report.

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Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin Degludec.

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Pharmacist Counseling Corner

Insulin Degludec & Supplements: Common Questions

What supplements interact with Insulin Degludec?
In our interaction database, 239 supplement and herbal ingredients have an interaction with Insulin Degludec on file — 1 rated major, 208 moderate, and 30 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, American Ginseng, Astragalus.
Which Insulin Degludec supplement interactions are the most serious?
The 1 major-rated combination — led by Siberian Cocklebur — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin Degludec?
That depends entirely on which supplement. The honest answer for Insulin Degludec is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Tresiba have the same supplement interactions as Insulin Degludec?
Yes — Tresiba all contain Insulin Degludec, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin Degludec deplete any vitamins or nutrients?
It might — Insulin Degludec has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin Degludec nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin Degludec and my other medications?
This page covers Insulin Degludec against supplements and herbal ingredients. Checking Insulin Degludec against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Insulin Degludec (rDNA Origin) Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.