Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Pindolol?

Hydrochlorothiazide, Pindolol brand name: Viskazide. Every interaction below applies to the brands too.

276 Interactions 11 Major 234 Moderate 31 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Pindolol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Pindolol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Viskazide is a two-in-one blood pressure treatment, hydrochlorothiazide (a water pill) plus pindolol (a beta blocker), which means supplements that touch blood pressure, fluid balance, or potassium can hit it from both directions. This combination deserves genuine caution, since 11 of the 276 interactions on file are rated major, and most of the rest either add to the pressure-lowering effect or deepen the diuretic's pull on electrolytes. Start with the majors: calcium-heavy products like dolomite can push calcium dangerously high alongside a thiazide, and yellow dock can worsen potassium loss.

The 234 moderate entries are quieter but real, and only 31 rate minor. Many can nudge blood pressure down further, a few work against it, and some add to the sun sensitivity hydrochlorothiazide already causes. Activated charcoal can also keep the pills from absorbing at all, so space anything like it well apart from your dose.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 234 Minor 31 No known interaction 1,176

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Hydrochlorothiazide, Pindolol: Top Interactions at a Glance

The most significant Hydrochlorothiazide, Pindolol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 276 interacting ingredients — plus 1,176 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Hydrochlorothiazide, Pindolol + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Hydrochlorothiazide, Pindololi

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Hydrochlorothiazide, Pindololi

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Likely Tyramine + Hydrochlorothiazide, Pindololi

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Hydrochlorothiazide, Pindololi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Hydrochlorothiazide, Pindololi

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Dolomite + Hydrochlorothiazide, Pindololi

Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Pindolol

All 1,452 ingredients in our database, ranked by severity — 276 with a Hydrochlorothiazide, Pindolol interaction on file and 1,176 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Pindolol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Hydrochlorothiazide, Pindolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.

Full Calcium + Hydrochlorothiazide, Pindolol answer

Can you take Cat's Claw with Hydrochlorothiazide, Pindolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.

Full Cat's Claw + Hydrochlorothiazide, Pindolol answer

Can you take American Ivy with Hydrochlorothiazide, Pindolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The berries of American ivy contain up to 2% oxalic acid, which can be toxic because it has the potential to cause kidney failure by precipi...

Full American Ivy + Hydrochlorothiazide, Pindolol answer

Can you take Thyroid Extract with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Hydrochlorothiazide, Pindolol answer

Can you take 1,3-dmba with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, 1,3-DMBA might modestly increase the levels of CYP2D6 substrates.

Full 1,3-dmba + Hydrochlorothiazide, Pindolol answer

Can you take Agar with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Hydrochlorothiazide, Pindolol answer

Can you take Algin with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Hydrochlorothiazide, Pindolol answer

Can you take American Spikenard with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. American spikenard is purported to have diaphoretic properties.

Full American Spikenard + Hydrochlorothiazide, Pindolol answer

Can you take Beet with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.

Full Beet + Hydrochlorothiazide, Pindolol answer

Can you take Birch with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, birch might interfere with diuretic therapy.

Full Birch + Hydrochlorothiazide, Pindolol answer

Can you take Bitter Orange with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.

Full Bitter Orange + Hydrochlorothiazide, Pindolol answer

Can you take Black Psyllium with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Hydrochlorothiazide, Pindolol answer

Can you take Blond Psyllium with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Hydrochlorothiazide, Pindolol answer

Can you take Carob with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Hydrochlorothiazide, Pindolol answer

Can you take Coenzyme Q10 with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Hydrochlorothiazide, Pindolol answer

Can you take Fenugreek with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fenugreek may also have an additive effect on blood pressure-lowering medications.

Full Fenugreek + Hydrochlorothiazide, Pindolol answer

Can you take Fucus Vesiculosus with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.

Full Fucus Vesiculosus + Hydrochlorothiazide, Pindolol answer

Can you take Hordenine with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full Hordenine + Hydrochlorothiazide, Pindolol answer

Can you take Humann Superbeets Heart Chews with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews).

Full Humann Superbeets Heart Chews + Hydrochlorothiazide, Pindolol answer

Can you take Juniper with Hydrochlorothiazide, Pindolol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Full Juniper + Hydrochlorothiazide, Pindolol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Pindolol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Pindolol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Pindolol sits in 11 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Pindolol through this category.

Related: does Hydrochlorothiazide, Pindolol deplete any nutrients?

Hydrochlorothiazide, Pindolol has 10 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Pindolol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Pindolol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Pindolol.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Pindolol & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Pindolol?
In our interaction database, 276 supplement and herbal ingredients have an interaction with Hydrochlorothiazide, Pindolol on file — 11 rated major, 234 moderate, and 31 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Pindolol supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Pindolol?
That depends entirely on which supplement. The honest answer for Hydrochlorothiazide, Pindolol is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Viskazide have the same supplement interactions as Hydrochlorothiazide, Pindolol?
Yes — Viskazide all contain Hydrochlorothiazide, Pindolol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Pindolol deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Pindolol has 10 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Pindolol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Pindolol and my other medications?
This page covers Hydrochlorothiazide, Pindolol against supplements and herbal ingredients. Checking Hydrochlorothiazide, Pindolol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.