Herb & supplement monograph

English Ivy Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how English Ivy interacts with medications. The heart of this page is the interaction list — every drug English Ivy is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what English Ivy is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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English Ivy Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant English Ivy drug interaction appears low for most people. None of the listed interactions are rated major, and all of them come from lab research alone, with no confirmed reports of problems in people so far.

Interactions deserving the most attention

No individual medication stands out with strong human evidence. Every flagged combination falls into one theme: medications cleared by the CYP2C19, CYP2C8, or CYP2D6 liver enzymes. Lab studies suggest English ivy may slow these enzymes, which could in theory raise the levels of medications that depend on them. Because this has not been shown to happen in people, it remains a theoretical caution rather than a proven risk.

What the rest of the list means

The long list of moderate interactions mostly reflects how many everyday medications rely on these three enzymes, not evidence that each pairing is harmful. All of the entries trace back to the same laboratory finding, and none of the predicted effects have been reported in humans. In short, English ivy's interaction profile looks broad on paper but is thin on real-world evidence.

Check your medications against English Ivy

Based on HelloPharmacist’s English Ivy interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with English Ivy

280 medications have a known interaction with English Ivy, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AbrocitinibCibinqo
Moderate Cytochrome P450 2c19 (cyp2c19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.

Read the full English Ivy + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Chlorzoxazone, Codeine interaction
Acetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Codeine interaction
Acetaminophen, Codeine, DoxylamineMersyndol
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Codeine, Doxylamine interaction
Acetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Codeine, Methocarbamol interaction
Acetaminophen, DextromethorphanTylenol Cough Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Dextromethorphan interaction
Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction
Acetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Hydrocodone interaction
Acetaminophen, MeperidineDemerol APAP
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Meperidine interaction
Acetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Oxycodone interaction
Acetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.

Read the full English Ivy + Acetaminophen, Propoxyphene interaction
Aerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
Moderate Cytochrome P450 2c19 (cyp2c19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.

Read the full English Ivy + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact English Ivy combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs English Ivy affects

Every type of medication (drug category) English Ivy is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories English Ivy interacts with
Cytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2c8 (cyp2c8) SubstratesCytochrome P450 2d6 (cyp2d6) Substrates
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
In vitro research shows that English ivy inhibits CYP2C8 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Monograph

English Ivy: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many European herbal products. Some research suggests it may help with certain coughs, but the evidence is still limited and mixed. The raw plant is poisonous if eaten and can irritate skin, so only use properly prepared commercial products and check with your pharmacist first.

English Ivy
Scientific name
Hedera helix
Family
Araliaceae
Part used
Leaves (dried leaf extract)
Common forms
Syrups, cough drops, oral drops, capsules, tea, topical preparations
People commonly use it for
  • Cough and chest congestion
  • Bronchitis
  • Asthma symptoms
  • Sore throat
  • Skin irritation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Standardized leaf-extract products are generally well tolerated, but the raw plant is toxic and can cause poisoning or skin reactions.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using. A small retrospective study suggests that taking English ivy leaf extract at an unknown dose...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

English ivy (Hedera helix) is a climbing evergreen vine native to Europe and parts of Asia. It is well known as a decorative plant that grows on walls, fences, and trees, with dark green, glossy leaves.

In herbal medicine, the dried leaves are used to make extracts that are added to cough syrups, drops, and lozenges. These products are especially popular in Europe, where ivy leaf extract is a common ingredient in over-the-counter cough remedies. Traditionally, ivy has also been used for breathing problems, inflammation, and skin issues.

It is important to know the difference between the raw plant and a standardized commercial extract. The raw leaves and berries are poisonous if swallowed, while properly made extracts are processed to be safer for use.

How it works

English ivy leaves contain natural compounds called saponins, including one called hederacoside C (which the body can turn into alpha-hederin). These saponins are believed to be the main active ingredients.

Researchers think these compounds may help thin and loosen mucus so it is easier to cough up, and may help relax the airways to make breathing easier. Laboratory studies also suggest ivy may have some anti-inflammatory and antimicrobial effects.

It is important to remember that much of this information comes from laboratory and animal research, and the exact way ivy works in people is not fully understood.

Effectiveness

Does English Ivy work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 8 uses evaluated
8 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For English Ivy, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 8 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Bronchitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral English ivy leaf extract is beneficial in patients with acute or chronic bronchitis.

Insufficient Reliable Evidence To Rate Burns
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical English ivy for burns, there is insufficient reliable information about the clinical effects of English ivy for this purpose.

Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Oral English ivy has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Gout
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral English ivy for gout, there is insufficient reliable information about the clinical effects of English ivy for this purpose.

Insufficient Reliable Evidence To Rate Neuropathic pain
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical English ivy for neuropathic pain, there is insufficient reliable information about the clinical effects of English ivy for this purpose.

Insufficient Reliable Evidence To Rate Respiratory tract infections
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral English ivy for respiratory tract infections, there is insufficient reliable information about the clinical effects of English ivy for this purpose.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral and topical English ivy for RA, there is insufficient reliable information about the clinical effects of English ivy for this purpose.

Insufficient Reliable Evidence To Rate Spasticity
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral English ivy for spasticity, there is insufficient reliable information about the clinical effects of English ivy for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Standardized ivy leaf extract products are generally considered well tolerated when used as directed for short periods. However, the raw plant is toxic. Eating the leaves or berries can cause poisoning, and touching the plant can cause skin rashes in sensitive people.

People with allergies to plants in the ivy family (Araliaceae) should be cautious. Children should only use products made specifically for children and only under guidance from a healthcare provider.

For pregnancy and breastfeeding, there is not enough reliable safety information. To be safe, English ivy should be avoided during pregnancy and while breastfeeding unless a doctor specifically recommends it. Always talk to a pharmacist or doctor before starting any herbal product, especially if you have a chronic health condition or take other medicines.

Side effects

When taken as a properly made extract, side effects are usually mild. The most common ones include stomach upset, nausea, vomiting, or diarrhea, especially at higher doses.

Allergic reactions are possible. Skin contact with the plant can cause redness, itching, or a rash (contact dermatitis). Rarely, more serious allergic reactions can happen.

Swallowing the raw plant or large amounts can cause poisoning, with symptoms such as severe stomach pain, vomiting, and in serious cases trouble breathing. Seek medical help right away if poisoning is suspected.

English Ivy: Reported Adverse Effects

Documented safety reports on English Ivy from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally and topically, English ivy leaf extract seems to be generally well tolerated.

Most Common Adverse Effects:

Orally: Abdominal pain, diarrhea, nausea, skin irritation, vomiting.

Topically: Allergic reactions, contact dermatitis.

Reports by condition
Dermatitis Dermatologic

Orally, English ivy and fresh English ivy leaves can cause skin irritation.

Topically, fresh English ivy leaves can cause contact dermatitis and rash, with frequent exposure increasing the risk of sensitization. Occupational airborne exposure to English ivy can also cause contact dermatitis.

  1. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  2. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16
  3. García M, Fernández E, Navarro JA, et al. Allergic contact dermatitis from Hedera helix L. Contact Dermatitis 1995;33(2):133-4.
  4. Hausen BM, Brohan J, Konig WA, et al. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Contact Dermatitis 1987;17(1):1-9.
  5. Mitchell, J. C. Allergic contact dermatitis from Hedera helix and Brassaia actinophylla (Araliaceae). Contact Dermatitis 1981;7(3):158-159.
  6. Boyle J, Harman RM. Contact dermatitis to Hedera helix (common ivy). Contact Dermatitis 1985;12(2):111-112.
  7. Yesudian PD, Franks A. Contact dermatitis from Hedera helix in a husband and wife. Contact Dermatitis 2002;46(2):125-126.
  8. Jones JM, White IR, White JM, McFadden JP. Allergic contact dermatitis to English ivy (Hedera helix)--a case series. Contact Dermatitis. 2009 Mar;60(3):179-80.
  9. Lurquin E, Swinnen I, Goossens A. Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. Contact Dermatitis. 2012;66(6):352-3.
  10. Paulsen E, Christensen LP, Andersen KE. Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. Contact Dermatitis. 2010;62(4):201-9.
  11. Bregnbak D, Menné T, Johansen JD. Airborne contact dermatitis caused by common ivy (Hedera helix L. ssp. helix). Contact Dermatitis. 2015;72(4):243-4.
Diarrhea Gastrointestinal

Orally, English ivy can cause abdominal pain, diarrhea, nausea, and vomiting. The saponin constituents of English ivy can produce an acrid and/or bitter taste.

  1. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16
  2. Kruttschnitt E, Wegener T, Zahner C, Henzen-Bücking S. Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis. Evid Based Complement Alternat Med. 2020 May 4;2
  3. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single official standardized dose of English ivy for everyone. The right amount depends on the specific product, its strength, and the form (syrup, drops, or capsules).

The best approach is to follow the directions on the product label and use only products made for human use. Doses for children are different from those for adults, so use children's products only as labeled.

Because products vary widely, check with your pharmacist or doctor before using English ivy to make sure it is appropriate for you and that you are using a safe amount.

Pregnancy & Breastfeeding

English Ivy & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using. A small retrospective study suggests that taking English ivy leaf extract at an unknown dose or duration during pregnancy is not associated with changes in pregnancy duration, the rate of preterm birth, infant health complications, or infant deaths. However, due to its small size, retrospective design, and insufficient information regarding dose and duration, further research is needed to determine the safety of English ivy during pregnancy.

English Ivy & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 13 references that drive our English Ivy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  2. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16 PubMed
  3. García M, Fernández E, Navarro JA, et al. Allergic contact dermatitis from Hedera helix L. Contact Dermatitis 1995;33(2):133-4.
  4. Hausen BM, Brohan J, Konig WA, et al. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Contact Dermatitis 1987;17(1):1-9.
  5. Mitchell, J. C. Allergic contact dermatitis from Hedera helix and Brassaia actinophylla (Araliaceae). Contact Dermatitis 1981;7(3):158-159.
  6. Boyle J, Harman RM. Contact dermatitis to Hedera helix (common ivy). Contact Dermatitis 1985;12(2):111-112. PubMed
  7. Yesudian PD, Franks A. Contact dermatitis from Hedera helix in a husband and wife. Contact Dermatitis 2002;46(2):125-126.
  8. Bregnbak D, Menné T, Johansen JD. Airborne contact dermatitis caused by common ivy (Hedera helix L. ssp. helix). Contact Dermatitis. 2015;72(4):243-4.
  9. Jones JM, White IR, White JM, McFadden JP. Allergic contact dermatitis to English ivy (Hedera helix)--a case series. Contact Dermatitis. 2009 Mar;60(3):179-80.
  10. Lurquin E, Swinnen I, Goossens A. Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. Contact Dermatitis. 2012;66(6):352-3.
  11. Paulsen E, Christensen LP, Andersen KE. Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. Contact Dermatitis. 2010;62(4):201-9.
  12. Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
  13. Kruttschnitt E, Wegener T, Zahner C, Henzen-Bücking S. Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis. Evid Based Complement Alternat Med. 2020 May 4;2
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with English Ivy

39 brands in our database make a supplement containing English Ivy.

Product directory

Supplement products with English Ivy

118 products in our database contain English Ivy. Open any to see its full ingredient list and every drug interaction we check.

Common Ivy Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Common Ivy Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Common Ivy Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Common Ivy Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Complete Cough Syrup+ Immune Natural Berry Flavor by Zarbee's Liquid 8 Fluid Ounce(s) · 236 mL View ingredients & interactions Cough & Mucus by Garden of Life MyKind Organics Liquid 5 Fluid Ounce(s) · 150 mL View ingredients & interactions Cough & Mucus by Garden of Life MyKind Organics Liquid 5 Fluid Ounce(s) · 150 Milliliter(s) View ingredients & interactions Cough Syrup by Gaia Herbs Liquid 4 Fluid Ounce(s) · 118 Milliliter(s) View ingredients & interactions Cough Syrup + Mucus & Immune Natural Berry Flavor by Zarbee's Naturals Liquid 4 Fluid Ounce(s) · 118 Milliliter(s) View ingredients & interactions Cough Syrup + Mucus Natural Grape Flavor by Zarbee's Naturals Liquid 4 Fluid Ounce(s) · 118 Milliliter(s) View ingredients & interactions Cough Syrup + Mucus, Throat & Nasal Natural Grape Flavor by Zarbee's Naturals Liquid 4 Fluid Ounce(s) · 118 Milliliter(s) View ingredients & interactions Cough Syrup Kids by Gaia Kids Liquid 4 Fluid Ounce(s) · 118 mL View ingredients & interactions Cough Syrup Nighttime by Gaia Herbs Liquid 4 Fluid Ounce(s) · 118 mL View ingredients & interactions Cough Syrup+ Mucus Natural Honey Lemon Flavor by Zarbee's Liquid 8 Fluid Ounce(s) · 236 mL View ingredients & interactions Echinacea Ivy by Allergy Research Group Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Echinacea Plus by NutriCology Capsule 60 Vegetarian Capsules View ingredients & interactions English Ivy Syrup Natural Raspberry Flavor by Genestra Brands Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Full Spectrum Coccinia Cordifolia Ivy Gourd 400 mg by Swanson Premium Brand Capsule 60 Capsule(s) View ingredients & interactions Herbal EXPEC Natural Cherry Flavor by Naturade Liquid 4.2 Fluid Ounce(s) · 125 mL View ingredients & interactions Immune Respiratory by Vimerson Health Capsule 60 Vegan Capsule(s) View ingredients & interactions Ivy Calm by Integrative Therapeutics Liquid 3.4 fl. Oz. · 100 mL View ingredients & interactions Ivy Calm by Integrative Therapeutics Liquid 4.05 fl. Oz. · 120 mL View ingredients & interactions Ivy Extract 50 mg by Nature's Way Tablet Or Pill 90 Vegan Tablet(s) View ingredients & interactions Ivy Extract 50 mg by Nature's Way Tablet Or Pill 90 Vegan Tablet(s) View ingredients & interactions
Pharmacist Counseling Corner

English Ivy: Common Questions

What is English Ivy used for, and does it work?
People use English Ivy for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does English Ivy interact with prescription medications?
Yes. We list 280 medications with a known interaction with English Ivy. Use the checker above to see how English Ivy interacts with a specific drug.
How are English Ivy interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take English Ivy with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this English Ivy interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is English Ivy used for?
It is most often used in cough syrups and drops to help loosen mucus and ease coughing from colds, bronchitis, or asthma. It is also used traditionally for sore throat, inflammation, and skin irritation.
Is English Ivy safe to take?
Properly made commercial extracts are generally well tolerated for short-term use, but the raw plant is poisonous if eaten and can irritate the skin. Only use products designed for human use and check with your pharmacist first.
Can I use English Ivy during pregnancy or while breastfeeding?
There is not enough reliable safety information, so it is best to avoid English Ivy during pregnancy and breastfeeding unless your doctor tells you otherwise.
Does English Ivy actually help with coughs?
Some studies suggest ivy leaf extract may help loosen mucus and reduce coughing, but the evidence is limited and not fully convincing. More high-quality research is needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain English Ivy

A rotating sample of real supplements in our database that list English Ivy — open any to see its full ingredients and every drug interaction we check.

See all 118 products with English Ivy →
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