Medication interaction hub

What Supplements Interact with Chlorothiazide, Methyldopa?

Chlorothiazide, Methyldopa brand names: Aldoclor 150, Aldochlor, Aldoclor 250. Every interaction below applies to the brands too.

258 Interactions 13 Major 220 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorothiazide, Methyldopa? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorothiazide, Methyldopa against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Aldoclor pairs chlorothiazide, a water pill, with methyldopa, an older blood pressure medicine, and its supplement list is one to treat with genuine care. Thirteen of the 258 ingredients on file are rated major, and most of the remaining 220 moderate and 25 minor entries do one of two things: drop blood pressure lower than intended, or add to the diuretic's pull on fluid and potassium.

The everyday items are the ones that catch people. Calcium supplements and dolomite can combine with the thiazide to push blood calcium dangerously high, and regular beer or wine adds strain to a liver that methyldopa can already stress. Around twenty entries make skin more sensitive to sun, and a small group can blunt absorption of the pill itself, so those need spacing well apart from a dose. Start with the thirteen majors and ask your pharmacist about any that match what you take.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 220 Minor 25 No known interaction 1,194

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Chlorothiazide, Methyldopa: Top Interactions at a Glance

The Chlorothiazide, Methyldopa supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 258 interacting ingredients — plus 1,194 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Chlorothiazide, Methyldopa Combinations Today

The Chlorothiazide, Methyldopa + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Asparagus + Chlorothiazide, Methyldopai

Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Read the full interaction Moderate Likelihood Probable Iron + Chlorothiazide, Methyldopai

Iron might decrease methyldopa levels by reducing its absorption.

Read the full interaction Moderate Likelihood Possible Pleurisy Root + Chlorothiazide, Methyldopai

Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion...

Read the full interaction Moderate Likelihood Possible Coffee + Chlorothiazide, Methyldopai

Theoretically, concomitant use might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Possible Caffeine + Chlorothiazide, Methyldopai

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Possible Green Tea + Chlorothiazide, Methyldopai

Theoretically, using green tea with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorothiazide, Methyldopa

All 1,452 ingredients in our database, ranked by severity — 258 with a Chlorothiazide, Methyldopa interaction on file and 1,194 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorothiazide, Methyldopa?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Asparagus with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Full Asparagus + Chlorothiazide, Methyldopa answer

Can you take Iron with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Iron might decrease methyldopa levels by reducing its absorption.

Full Iron + Chlorothiazide, Methyldopa answer

Can you take Pleurisy Root with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to...

Full Pleurisy Root + Chlorothiazide, Methyldopa answer

Can you take Coffee with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of hypokalemia.

Full Coffee + Chlorothiazide, Methyldopa answer

Can you take Caffeine with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.

Full Caffeine + Chlorothiazide, Methyldopa answer

Can you take Rue with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Chlorothiazide, Methyldopa answer

Can you take Saffron with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.

Full Saffron + Chlorothiazide, Methyldopa answer

Can you take Sage with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase or decrease the effects of antihypertensive drugs.

Full Sage + Chlorothiazide, Methyldopa answer

Can you take Saigon Cinnamon with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Chlorothiazide, Methyldopa answer

Can you take Sea Buckthorn with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Full Sea Buckthorn + Chlorothiazide, Methyldopa answer

Can you take Senna with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Senna + Chlorothiazide, Methyldopa answer

Can you take Slippery Elm with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Chlorothiazide, Methyldopa answer

Can you take Sodium Bicarbonate with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking thiazide diuretics.

Full Sodium Bicarbonate + Chlorothiazide, Methyldopa answer

Can you take Soy with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Full Soy + Chlorothiazide, Methyldopa answer

Can you take Spearmint with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Chlorothiazide, Methyldopa answer

Can you take Squill with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Squill contains cardiac glycosides.

Full Squill + Chlorothiazide, Methyldopa answer

Can you take St. John's Wort with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Chlorothiazide, Methyldopa answer

Can you take Star Of Bethlehem with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.

Full Star Of Bethlehem + Chlorothiazide, Methyldopa answer

Can you take Stinging Nettle with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Full Stinging Nettle + Chlorothiazide, Methyldopa answer

Can you take Strophanthus with Chlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and strophanthus can increase the risk of cardiac glycoside toxicity due to...

Full Strophanthus + Chlorothiazide, Methyldopa answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorothiazide, Methyldopa is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorothiazide, Methyldopa, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorothiazide, Methyldopa sits in 9 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Chlorothiazide, Methyldopa through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Chlorothiazide, Methyldopa through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Chlorothiazide, Methyldopa through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorothiazide, Methyldopa through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorothiazide, Methyldopa through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Chlorothiazide, Methyldopa through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Chlorothiazide, Methyldopa through this category.

Methyldopa (Aldomet) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Chlorothiazide, Methyldopa through this category.

Alpha-Adrenergic Antagonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chlorothiazide, Methyldopa through this category.

Related: does Chlorothiazide, Methyldopa deplete any nutrients?

Chlorothiazide, Methyldopa has 27 reported nutrient associations in the research literature — see the Chlorothiazide, Methyldopa nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorothiazide, Methyldopa

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorothiazide, Methyldopa.

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Pharmacist Counseling Corner

Chlorothiazide, Methyldopa & Supplements: Common Questions

What supplements interact with Chlorothiazide, Methyldopa?
Our database currently documents 258 ingredients with a known Chlorothiazide, Methyldopa interaction (13 major, 220 moderate, 25 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 258. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Chlorothiazide, Methyldopa supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorothiazide, Methyldopa?
Plenty of supplements coexist fine with Chlorothiazide, Methyldopa; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Aldoclor 150 have the same supplement interactions as Chlorothiazide, Methyldopa?
Yes — Aldoclor 150, Aldochlor, Aldoclor 250 all contain Chlorothiazide, Methyldopa, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Chlorothiazide, Methyldopa deplete any vitamins or nutrients?
It might — Chlorothiazide, Methyldopa has 27 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Chlorothiazide, Methyldopa nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Chlorothiazide, Methyldopa and my other medications?
This page covers Chlorothiazide, Methyldopa against supplements and herbal ingredients. Checking Chlorothiazide, Methyldopa against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.