Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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Melphalan Injection 140 Memantine 24 Meningococcal Vaccine 11 Mepartricin 1 Mepenzolate 12 Meperidine 66 Mephenesin 4 Mephenytoin 2 Mephobarbital 31 Mepindolol 8 Mepivacaine 1 Meprobamate 21 Meptazinol 21 Mercaptopurine 218 Meropenem 31 Meropenem Injection 27 Mesalamine 115 Mesalamine Rectal 102 Mesoridazine 87 Mesterolone 1 Mestranol 48 Metaclazepam 7 Metaproterenol 4 Metaxalone 30 Metergoline 7 Metformin 378 Methacholine 26 Methacycline 19 Methadone 129 Methamphetamine 28 Methamphetamine Hydrochloride 1 Methandriol 1 Methandrostenolone 1 Methantheline 1 Methazolamide 10 Methdilazine 22 Methenamine 2 Methenolone 1 Methicillin 15 Methimazole 45 Methixene 1 Methocarbamol 25 Methohexital 27 Methotrexate 420 Methotrexate Injection 354 Methotrimeprazine 59 Methoxsalen 1 Methoxyflurane 11 Methoxyphenamine 1 Methsuximide 12 Methyclothiazide 51 Methyldopa 53 Methylene Blue 45 Methylergonovine 226 Methylnaltrexone 5 Methylnaltrexone Injection 4 Methylphenidate 71 Methylphenidate Transdermal Patch 67 Methylprednisolone 58 Methyltestosterone 4 Methysergide 8 Metildigoxin 12 Metipranolol 58 Metoclopramide 35 Metoclopramide Injection 247 Metoclopramide Nasal Spray 247 Metocurine 16 Metolazone 72 Metopimazine 4 Metoprolol 62 Metreleptin 11 Metrizamide 1 Metronidazole 278 Metronidazole Injection 242 Metronidazole Topical 242 Metronidazole Vaginal 242 Metyrapone 4 Mexiletine 82 Mezlocillin 6 Mibefradil 20 Mibolerone 1 Micafungin 5 Miconazole 45 Miconazole Buccal 37 Miconazole Topical 37 Miconazole Vaginal 37 Midazolam 39 Midazolam Hydrochloride 2 Midazolam Injection 276 Midazolam Nasal Spray 276 Midodrine 9 Midodrine Hydrochloride 1 Midostaurin 133 Mifepristone 225 Miglitol 107 Milk Thistle 9 Milnacipran 68 Milrinone 1 Milsaperidone 62 Mineral Oil 5 Minocycline 112 Minocycline Topical 94 Minoxidil 3 Minoxidil Topical 3 Miokamycin 3 Mirabegron 16 Mirikizumab-Mrkz 17 Mirtazapine 78 Mirvetuximab Soravtansine-Gynx 1 Mirvetuximab Soravtansine-Gynx Injection 33 Misoprostol 1 Mitapivat 295 Mitomycin 18 Mitomycin Pyelocalyceal 18 Mitotane 99 Mitoxantrone Injection 17 Mivacurium 19 Mizolastine 41 Mobocertinib 105 Moclobemide 16