Herb & supplement monograph

Eurycoma Longifolia Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Eurycoma Longifolia interacts with medications. The heart of this page is the interaction list — every drug Eurycoma Longifolia is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Eurycoma Longifolia is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with Eurycoma Longifolia

248 medications have a known interaction with Eurycoma Longifolia, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Hydrochlorothiazide, PropranololInderide
Moderate Propranolol (inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.

Read the full Eurycoma Longifolia + Hydrochlorothiazide, Propranolol interaction
PropranololAngilol, Bedranol SR, Beta Prograne, Half Beta Prograne, Half-Inderal LA, Inderal +6 more
Moderate Propranolol (inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.

Read the full Eurycoma Longifolia + Propranolol interaction Propranolol drug page: uses, dosage & side effects
Propranolol HydrochlorideHemangeol
Moderate Propranolol (inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.

Read the full Eurycoma Longifolia + Propranolol Hydrochloride interaction Propranolol Hydrochloride drug page: uses, dosage & side effects
AbrocitinibCibinqo
Minor Cytochrome P450 2c19 (cyp2c19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.

Read the full Eurycoma Longifolia + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen interaction Acetaminophen drug page: uses, dosage & side effects
Acetaminophen, AspirinGemnisyn
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction
Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Butalbital interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Minor Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Eurycoma Longifolia combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Eurycoma Longifolia affects

Every type of medication (drug category) Eurycoma Longifolia is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Eurycoma Longifolia interacts with
Propranolol (inderal)Cytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2a6 (cyp2a6) SubstratesCytochrome P450 2c19 (cyp2c19) SubstratesTestosterone
Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Monograph

Eurycoma Longifolia: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits. However, the overall evidence is still limited and product quality varies widely, so talk with your pharmacist or doctor before using it, and avoid it if you are pregnant or breastfeeding.

Eurycoma Longifolia
Scientific name
Eurycoma longifolia
Family
Simaroubaceae
Part used
Root (and root extracts)
Common forms
Capsules, tablets, powder, extracts, teas, and blended supplement products
People commonly use it for
  • Low testosterone or low libido in men
  • Male fertility support
  • Athletic performance and muscle strength
  • Energy and fatigue
  • Stress and mood
  • General male enhancement

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally tolerated short-term in studies, but long-term safety and product quality are uncertain.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using. Animal research suggests that there are no negative effects of Eurycoma longifolia on the of...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using. Animal research suggests that there are no negative effects of Eurycoma longifolia on the of...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Eurycoma longifolia is a flowering plant native to Southeast Asia, including Malaysia, Indonesia, Thailand, and Vietnam. It is best known by the name tongkat ali and is sometimes called "Malaysian ginseng." The plant's root has a long history of use in traditional medicine across the region.

People most often take it for so-called "male enhancement" reasons, such as boosting testosterone, libido, sexual function, and fertility. It is also marketed for energy, exercise performance, and stress. Today it is widely sold as capsules, powders, extracts, and as an ingredient in combination supplements.

How it works

Eurycoma longifolia contains compounds called quassinoids (such as eurycomanone) and other plant chemicals thought to be responsible for its effects.

The main proposed idea is that it may influence hormones — for example, by affecting how testosterone is released or freed from binding proteins in the blood. Researchers have also suggested possible antioxidant and stress-related effects. It is worth noting that much of this understanding comes from laboratory and animal studies, and the exact way it works in the human body is not fully understood.

Effectiveness

Does Eurycoma Longifolia work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 16 uses evaluated
1 Possibly effective 1 Leans ineffective 14 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Sexual desire
Rating & evidence shown verbatim from Natural Medicines

Oral Eurycoma longifolia seems to improve sexual desire.

Possibly Ineffective Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Oral Eurycoma longifolia does not seem to improve athletic performance in healthy persons.

Also studied for 14 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related testosterone deficiency
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Eurycoma longifolia is beneficial for increasing testosterone levels in older males.

Insufficient Reliable Evidence To Rate Back pain
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Eurycoma longifolia for back pain, there is insufficient reliable information about the clinical effects of Eurycoma longifolia for this condition.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Eurycoma longifolia for cancer, there is insufficient reliable information about the clinical effects of Eurycoma longifolia for this condition.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Eurycoma longifolia for diabetes, there is insufficient reliable information about the clinical effects of Eurycoma longifolia for this condition.

Insufficient Reliable Evidence To Rate Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Eurycoma longifolia for dyspepsia, there is insufficient reliable information about the clinical effects of Eurycoma longifolia for this condition.

Insufficient Reliable Evidence To Rate Erectile dysfunction (ED)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Eurycoma longifolia is beneficial for ED.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Eurycoma longifolia for hypertension, there is insufficient reliable information about the clinical effects of Eurycoma longifolia for this condition.

Insufficient Reliable Evidence To Rate Intestinal parasite infection
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Eurycoma longifolia for intestinal parasite infection, there is insufficient reliable information about the clinical effects of Eurycoma longifolia for this purpose.

Insufficient Reliable Evidence To Rate Malaria
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Eurycoma longifolia for malaria, there is insufficient reliable information about the clinical effects of Eurycoma longifolia for this condition.

Insufficient Reliable Evidence To Rate Male Infertility
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Eurycoma longifolia is beneficial for improving male infertility.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

Oral Eurycoma longifolia has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Muscle strength
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Eurycoma longifolia is beneficial for improving muscle strength.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Oral Eurycoma longifolia has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Osteoporosis
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Eurycoma longifolia for osteoporosis, there is insufficient reliable information about the clinical effects of Eurycoma longifolia for this condition.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

In short-term studies, standardized extracts have generally been tolerated by healthy adults. However, the long-term safety is not well established, and supplement quality can vary a lot from product to product. Some imported or unregulated products have been reported to contain contaminants such as heavy metals (for example, mercury), so choosing reputable, third-party-tested brands matters.

People with hormone-sensitive conditions, prostate problems, or other ongoing health issues should be cautious and check with a healthcare professional first. Pregnant and breastfeeding women should avoid it because there is not enough safety information and the herb may affect hormones. Children should not use it.

Always tell your pharmacist or doctor about any supplement you are taking, especially if you have a medical condition or take other medicines.

Side effects

Reported side effects are usually mild and may include restlessness, trouble sleeping (insomnia), irritability, or mild stomach upset. Some people report increased body temperature feelings.

Because the herb may affect hormones, there is a theoretical concern about hormone-related effects with higher doses or long-term use. Concerns about heavy-metal contamination in some products are another reason to use only trusted brands. If you notice any unusual or concerning symptoms, stop using it and contact a healthcare professional.

Eurycoma Longifolia: Reported Adverse Effects

Documented safety reports on Eurycoma Longifolia from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Acne Endocrine

Some research in both humans and animals suggests that Eurycoma longifolia might increase testosterone levels. If testosterone levels are increased beyond the normal range, there is risk of testosterone-related side effects which could include acne, insulin resistance, hepatotoxicity, and others.

  1. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or universally agreed-upon dose for Eurycoma longifolia. Studies have used different standardized extracts at different strengths, which makes it hard to recommend one specific amount.

The best approach is to follow the directions on the product label and not exceed them. Because products differ greatly in strength and quality, check with your pharmacist or doctor before starting, and choose products that are third-party tested for purity.

Pregnancy & Breastfeeding

Eurycoma Longifolia & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using. Animal research suggests that there are no negative effects of Eurycoma longifolia on the offspring. However, research in humans is lacking.

Eurycoma Longifolia & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using. Animal research suggests that there are no negative effects of Eurycoma longifolia on the offspring. However, research in humans is lacking.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 4 references that drive our Eurycoma Longifolia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Eurycoma Longifolia

470 brands in our database make a supplement containing Eurycoma Longifolia.

Product directory

Supplement products with Eurycoma Longifolia

1,124 products in our database contain Eurycoma Longifolia. Open any to see its full ingredient list and every drug interaction we check.

Bomba V by Essential Source Tablet Or Pill 60 Rapid Response Tablet(s) View ingredients & interactions Bomba V by Essential Source Capsule 90 Rapid Response Capsule(s) View ingredients & interactions Boost Elite by ZHOU Capsule 90 Veggie Capsule(s) View ingredients & interactions Boost Elite by ZHOU Capsule 90 Vegetable Capsule(s) View ingredients & interactions Boost For Her by NutriONN Capsule 90 Capsule(s) View ingredients & interactions Booty Boost by SkinnyBean Tablet Or Pill 60 Tablet(s) View ingredients & interactions Botanabolic by LVLUP Health Capsule 90 Capsule(s) View ingredients & interactions BRI Testosterone by BRI Nutrition Capsule 60 Veggie Capsule(s) View ingredients & interactions Bull Boost by ONL Osyris Nutrition Lab Tablet Or Pill 60 Tablet(s) View ingredients & interactions Chainsaw by Vigor Labs Capsule 30 Capsule(s) View ingredients & interactions Chainsaw Gold by Vigor Labs Capsule 30 Capsule(s) View ingredients & interactions CholestGar by Planetary Herbals Tablet Or Pill 60 Tablet(s) View ingredients & interactions Climax by BioXgenic Capsule 60 Capsule(s) View ingredients & interactions Climax for Her by BioXgenic Capsule 60 Capsule(s) View ingredients & interactions Climaxia by HoltraCeuticals Capsule 60 Capsule(s) View ingredients & interactions Clinical Strength T-Bomb 3xtreme by MHP Maximum Human Performance Tablet Or Pill 168 Tablet(s) View ingredients & interactions Combat Tested 2.0 by Jocko Capsule 120 Capsule(s) View ingredients & interactions Competitive Mass by Lee Haney's Nutritional Support Systems Powder 910 g View ingredients & interactions Conception For Him by Eu Natural Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Conception Men by Eu Natural Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Conquer by Forbidden Labz Capsule 60 Capsule(s) View ingredients & interactions CortiTrax by VitaMonk Capsule 60 Capsule(s) View ingredients & interactions Cycle Support by Vintage Muscle Capsule 60 Capsule(s) View ingredients & interactions Cyclin With Growth Factors by MHP Maximum Human Performance Capsule 120 Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Eurycoma Longifolia: Common Questions

What is Eurycoma Longifolia used for, and does it work?
People use Eurycoma Longifolia for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Eurycoma Longifolia for Sexual desire. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Eurycoma Longifolia interact with prescription medications?
Yes. We list 248 medications with a known interaction with Eurycoma Longifolia. Use the checker above to see how Eurycoma Longifolia interacts with a specific drug.
How are Eurycoma Longifolia interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Eurycoma Longifolia with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Eurycoma Longifolia interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Eurycoma Longifolia (tongkat ali) used for?
It is most commonly used by men hoping to support testosterone, libido, sexual function, and fertility, and is also marketed for energy, exercise performance, and stress. Evidence for these uses is still limited.
Does it really raise testosterone?
Some small studies suggest it may modestly support testosterone, especially in men who already have low levels, but the research is limited and results are mixed. It is not a guaranteed or proven way to raise testosterone.
Is it safe to take?
Short-term use of quality, standardized extracts has generally been tolerated in studies, but long-term safety is unclear and some products have been found contaminated with heavy metals. Use trusted, tested brands and talk with your pharmacist or doctor first.
Can I take it during pregnancy or while breastfeeding?
No. There is not enough safety information and the herb may affect hormones, so it is best to avoid it during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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