Medication interaction hub

What Supplements Interact with Acetaminophen, Caffeine, Pyrilamine?

Acetaminophen, Caffeine, Pyrilamine brand name: Midol Max Strength Menstrual. Every interaction below applies to the brands too.

322 Interactions 16 Major 260 Moderate 46 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Caffeine, Pyrilamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Caffeine, Pyrilamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

322 supplements and herbal ingredients have interactions with Acetaminophen, Caffeine, Pyrilamine on file in the HelloPharmacist interaction database — 16 rated major, 260 moderate, and 46 minor. The most serious involve Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Ephedra.

Our assessment: with 16 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Acetaminophen, Caffeine, Pyrilamine.

Major 16 Moderate 260 Minor 46 No known interaction 1,130

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Caffeine, Pyrilamine: Top Interactions at a Glance

The Acetaminophen, Caffeine, Pyrilamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 322 interacting ingredients — plus 1,130 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Caffeine, Pyrilamine Combinations Today

The Acetaminophen, Caffeine, Pyrilamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Probable Vitamin C + Acetaminophen, Caffeine, Pyrilaminei

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full interaction Minor Likelihood Possible Vitamin D + Acetaminophen, Caffeine, Pyrilaminei

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Beet + Acetaminophen, Caffeine, Pyrilaminei

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Caffeine + Acetaminophen, Caffeine, Pyrilaminei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Black Pepper + Acetaminophen, Caffeine, Pyrilaminei

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Vitamin E + Acetaminophen, Caffeine, Pyrilaminei

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Caffeine, Pyrilamine

All 1,452 ingredients in our database, ranked by severity — 322 with a Acetaminophen, Caffeine, Pyrilamine interaction on file and 1,130 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Caffeine, Pyrilamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Acetaminophen, Caffeine, Pyrilamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Full Vitamin C + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Vitamin D with Acetaminophen, Caffeine, Pyrilamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Beet with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Caffeine with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Black Pepper with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Gotu Kola with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.

Full Gotu Kola + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Grape with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Full Grape + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Greater Celandine with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Guar Gum with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Guarana with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using guarana with diuretic drugs might increase the risk of hypokalemia.

Full Guarana + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Gum Arabic with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Gymnema with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.

Full Gymnema + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Hedge Mustard with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hedge mustard with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Full Hedge Mustard + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Hemp Agrimony with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Higenamine with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Hordenine with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties.

Full Hordenine + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Horny Goat Weed with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.

Full Horny Goat Weed + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Horsetail with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.

Full Horsetail + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Hu Zhang with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.

Full Hu Zhang + Acetaminophen, Caffeine, Pyrilamine answer

Can you take Huperzine A with Acetaminophen, Caffeine, Pyrilamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, huperzine A might decrease the effects of anticholinergic drugs.

Full Huperzine A + Acetaminophen, Caffeine, Pyrilamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Caffeine, Pyrilamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Caffeine, Pyrilamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Caffeine, Pyrilamine sits in 14 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Caffeine, Pyrilamine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Caffeine, Pyrilamine through this category.

Related: does Acetaminophen, Caffeine, Pyrilamine deplete any nutrients?

Acetaminophen, Caffeine, Pyrilamine has 8 reported nutrient associations in the research literature — see the Acetaminophen, Caffeine, Pyrilamine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Caffeine, Pyrilamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Caffeine, Pyrilamine.

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Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Acetaminophen, Caffeine, Pyrilamine & Supplements: Common Questions

What supplements interact with Acetaminophen, Caffeine, Pyrilamine?
In our interaction database, 322 supplement and herbal ingredients have an interaction with Acetaminophen, Caffeine, Pyrilamine on file — 16 rated major, 260 moderate, and 46 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Acetaminophen, Caffeine, Pyrilamine supplement interactions are the most serious?
The 16 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Caffeine, Pyrilamine?
That depends entirely on which supplement. The honest answer for Acetaminophen, Caffeine, Pyrilamine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Midol Max Strength Menstrual have the same supplement interactions as Acetaminophen, Caffeine, Pyrilamine?
Yes — Midol Max Strength Menstrual all contain Acetaminophen, Caffeine, Pyrilamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Caffeine, Pyrilamine deplete any vitamins or nutrients?
It might — Acetaminophen, Caffeine, Pyrilamine has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Caffeine, Pyrilamine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Caffeine, Pyrilamine and my other medications?
This page covers Acetaminophen, Caffeine, Pyrilamine against supplements and herbal ingredients. Checking Acetaminophen, Caffeine, Pyrilamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.