Herb & supplement monograph

Eleuthero Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Eleuthero interacts with medications. The heart of this page is the interaction list — every drug Eleuthero is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Eleuthero is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Eleuthero Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Eleuthero drug interaction appears low for most people. None of the listed interactions are rated major, and most rest on lab or animal findings rather than proven effects in people.

Interactions deserving the most attention

The best-supported concern involves diabetes medications, since a small human study found eleuthero lowered blood sugar over three months, which could add to the effect of these drugs, though another small study found the opposite in healthy people. Caution is also reasonable with blood thinners, because a component of eleuthero reduced platelet clumping in lab and animal research, and bleeding risk leaves little room for error. A single case report also described raised digoxin levels in a man taking eleuthero, which resolved when he stopped it.

What the rest of the list means

The long list of interacting medications looks worse than it is. Most entries are theoretical, based on how eleuthero might affect enzymes or transporters the body uses to clear medications. Notably, studies in healthy volunteers found that predicted effects on two major drug-clearing enzymes did not actually occur in people.

Check your medications against Eleuthero

Based on HelloPharmacist’s Eleuthero interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Eleuthero

1140 medications have a known interaction with Eleuthero, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
6-mercaptopurinePurinethol
Moderate Immunosuppressants

Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.

Read the full Eleuthero + 6-mercaptopurine interaction 6-mercaptopurine drug page: uses, dosage & side effects
AbciximabReoPro
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Eleuthero + Abciximab interaction
AbrocitinibCibinqo
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Eleuthero + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcalabrutinibCalquence
Moderate P-glycoprotein Substrates

Theoretically, eleuthero might increase levels of P-glycoprotein substrates.

Read the full Eleuthero + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.

Read the full Eleuthero + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcenocoumarolSintrom
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Eleuthero + Acenocoumarol interaction
AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen interaction Acetaminophen drug page: uses, dosage & side effects
Acetaminophen, AspirinGemnisyn
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Eleuthero + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction
Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Butalbital interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Eleuthero combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Eleuthero affects

Every type of medication (drug category) Eleuthero is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 10 drug categories Eleuthero interacts with
Anticoagulant/antiplatelet DrugsAntidiabetes DrugsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesDigoxin (lanoxin)ImmunosuppressantsP-glycoprotein SubstratesCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesOrganic Anion-transporting Polypeptide Substrates (oatp)
Anticoagulant/Antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.

Likelihood Unlikely Evidence D
Immunosuppressants

Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.

Likelihood Possible Evidence D
Monograph

Eleuthero: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so it should not replace proven treatments. It is generally well tolerated short-term, but pregnant and breastfeeding people and those with certain conditions should avoid it or check with a healthcare provider first.

Eleuthero
Scientific name
Eleutherococcus senticosus
Family
Araliaceae
Part used
Root and rhizome (sometimes the stem bark)
Common forms
Capsules, tablets, dried root powder, liquid extracts (tinctures), and teas
People commonly use it for
  • Fatigue and low energy
  • Physical and athletic performance
  • Stress resistance (adaptogen)
  • Immune support
  • Mental focus and alertness

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Often well tolerated for short-term use, but evidence on long-term safety is limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Eleuthero (Eleutherococcus senticosus) is a shrub native to parts of eastern Asia, including Russia, China, Korea, and Japan. The root and rhizome are the parts most often used in supplements and traditional medicine.

Eleuthero is often called 'Siberian ginseng,' but it is not a true ginseng and is not the same as Panax ginseng. The 'ginseng' name comes from marketing and from its history of similar traditional uses, not from a close botanical relationship.

It is frequently labeled an 'adaptogen' — a term for herbs that are claimed to help the body resist physical and mental stress. People take it for energy, stamina, focus, and immune support, usually as capsules, teas, or liquid extracts.

How it works

Eleuthero contains a group of compounds called eleutherosides, along with polysaccharides and other plant chemicals. These are thought to be the main active ingredients.

Researchers believe these compounds may influence how the body responds to stress, possibly by affecting stress hormones and the immune system. Some laboratory and animal studies suggest antioxidant and anti-inflammatory effects.

It is important to know that much of this work comes from test-tube and animal research. How well these effects apply to people taking eleuthero supplements is not well established.

Effectiveness

Does Eleuthero work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 22 uses evaluated
1 Possibly effective 21 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Genital herpes
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero root extract might help to prevent and reduce the severity of genital herpes outbreaks.

Also studied for 21 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral eleuthero root is not beneficial for improving athletic performance.

Insufficient Reliable Evidence To Rate Bipolar disorder
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero root is beneficial for bipolar disorder.

Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero fruit is beneficial for preventing the development of CVD.

Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero root is beneficial for CFS.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero is beneficial for cognitive function.

Insufficient Reliable Evidence To Rate Common cold
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero extract has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero is beneficial for improving glycemic control in type 2 diabetes.

Insufficient Reliable Evidence To Rate Diabetic neuropathy
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero is beneficial for diabetic neuropathy.

Insufficient Reliable Evidence To Rate Dry eye
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero root has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Familial Mediterranean fever
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Fibromyalgia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral eleuthero for fibromyalgia, there is insufficient reliable information about the clinical effects of eleuthero for this condition.

Insufficient Reliable Evidence To Rate Hangover
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero root is beneficial for hangovers.

Insufficient Reliable Evidence To Rate Influenza
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Osteoporosis
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Pneumonia
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Quality of life
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero root improves quality of life in older healthy adults.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral eleuthero for RA, there is insufficient reliable information about the clinical effects of eleuthero for this condition.

Insufficient Reliable Evidence To Rate Stress
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral eleuthero root is beneficial for stress.

Insufficient Reliable Evidence To Rate Upper respiratory tract infection (URTI)
Rating & evidence shown verbatim from Natural Medicines

Oral eleuthero has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Eleuthero is generally considered well tolerated for short-term use in healthy adults. Long-term safety has not been well studied.

Use caution or talk to your doctor first if you have high blood pressure, a heart condition, diabetes, a hormone-sensitive condition, an autoimmune disease, or a bleeding disorder, or if you are scheduled for surgery.

Pregnancy and breastfeeding: There is not enough reliable safety information, so eleuthero should be avoided during pregnancy and while breastfeeding.

Quality can vary between products, and some 'Siberian ginseng' products have been found to be mislabeled or contaminated. Choose products from reputable brands, ideally with third-party testing.

Side effects

When side effects occur, they are usually mild. Reported effects include trouble sleeping (especially if taken late in the day), nervousness or feeling jittery, headache, and stomach upset.

Less commonly, people have reported changes in blood pressure and heart palpitations. Stop using it and seek medical advice if you notice a fast or irregular heartbeat, severe headache, or signs of an allergic reaction such as rash, swelling, or trouble breathing.

Eleuthero: Reported Adverse Effects

Documented safety reports on Eleuthero from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, eleuthero root is generally well tolerated when used short-term.

Most Common Adverse Effects:

Orally: Diarrhea, dyspepsia, gastrointestinal upset, headache, nausea, and urticaria.

Reports by condition
Anxiety Psychiatric

Orally, nervousness has been reported in 7.3% of people taking eleuthero in one clinical study. Eleuthero has also been reported to cause slight anxiety, irritability, and melancholy in some patients. These adverse effects seem to be more likely to occur with higher doses.

  1. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61.
  2. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
Atherosclerosis Cardiovascular

Orally, increased blood pressure has been reported in children with hypotension taking eleuthero in one clinical study. Eleuthero has been reported to cause tachycardia, hypertension, and pericardial pain in patients with rheumatic heart disease or atherosclerosis. It is unclear if these effects were caused by eleuthero, or by the cardioglycoside-containing herb, silk vine (Periploca sepium), which is a common adulterant found in eleuthero products.

  1. Kaloeva, Z. D. [Effect of the glycosides of Eleutherococcus senticosus on the hemodynamic indices of children with hypotensive states]. Farmakol.Toksikol. 1986;49(5):73.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
  4. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
Diarrhea Gastrointestinal

Orally, eleuthero has been reported to cause dyspepsia, nausea, diarrhea, and gastrointestinal upset in some patients.

Mastalgia Genitourinary

Orally, mastalgia and uterine bleeding were reported in 7.3% of females taking eleuthero 2 grams daily in one clinical study. These adverse effects seem to be more likely with higher doses.

  1. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
  2. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61.
Subarachnoid hemorrhage Neurologic/CNS

Orally, headaches have been reported in 9.8% of people taking eleuthero in one clinical study.

In one case report, a 53-year-old female developed spontaneous subarachnoid hemorrhage associated with the use of an herbal supplement containing red clover, dong quai, and eleuthero. It is unclear if this event was related to the use of eleuthero, the other ingredients, the combination, or another cause entirely.

  1. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61.
  2. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized dose for eleuthero, and products differ widely in strength and form (dried root, extracts, tinctures, and teas).

The best approach is to follow the directions on the product label and not exceed the recommended amount. Many people take eleuthero earlier in the day to reduce the chance of sleep problems.

Because the right dose depends on the product and your health, check with a pharmacist or doctor before starting, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Eleuthero & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Eleuthero & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 24 references that drive our Eleuthero monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
  3. Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
  4. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
  5. Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alt Ther 2001;7:S14.
  6. Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
  7. Yun-Choi HS, Kim JH, Lee JR. Potential inhibitors of platelet aggregation from plant sources, III. J Nat Prod 1987;50:1059-64. PubMed
  8. Donovan JL, DeVane CL, Chavin KD, et al. Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers. Drug Metab Dispos 2003;31:519-22.. PubMed
  9. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
  10. Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 2004;23:248-58. PubMed
  11. Dasgupta A, Wu S, Actor J, et al. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 2003;119:298-303. DOI
  12. Takahashi T, Kaku T, Sato T, et al. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. J Nat Med. 2010;64(1):55-62. PubMed
  13. Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. PubMed
  14. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  15. Molokovskii, D. S., Davydov, V. V., and Tiulenev, V. V. [The action of adaptogenic plant preparations in experimental alloxan diabetes]. Probl.Endokrinol.(Mosk) 1989;35(6):82-87.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Eleuthero

625 brands in our database make a supplement containing Eleuthero.

Product directory

Supplement products with Eleuthero

3,937 products in our database contain Eleuthero. Open any to see its full ingredient list and every drug interaction we check.

#4 - B -P by Nutri-West Herbals Tablet Or Pill 100 Tablet(s) View ingredients & interactions +Mood Relief MoodLift Complex by Shaklee Capsule 120 Capsule(s) View ingredients & interactions +PlusShake Raw Chocolate by Greens+ Powder 1.5 lb · 677 Gram(s) View ingredients & interactions +PlusShake Raw Vanilla by Greens+ Powder 1.5 lb · 661 Gram(s) View ingredients & interactions 1 Before Packet by New Earth Edge Capsule 14 Packet(s) View ingredients & interactions 1 Before Packet by New Earth Edge Capsule 60 Packet(s) View ingredients & interactions 100% Pure Garcinia Cambogia Drops by Infiniti Creations Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions 100% Pure Green Coffee Bean Drops by Infiniti Creations Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions 100% Pure Raspberry Keytones Drops by Infiniti Creations Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions 2-Day Diet Detox Natural Berry Flavor by SuperJuice Liquid 473 mL View ingredients & interactions 3-Test-OXO by Legal Limit Labs Capsule 90 Capsule(s) View ingredients & interactions 37 Strawberries by Purity Products Capsule 30 Capsule(s) View ingredients & interactions 40+ Every Man II Multivitamin by New Chapter Tablet Or Pill 48 Tablet(s) View ingredients & interactions 40+ Every Man II Multivitamin by New Chapter Tablet Or Pill 96 Tablet(s) View ingredients & interactions 40+ Every Woman II Multivitamin by New Chapter Tablet Or Pill 48 Tablet(s) View ingredients & interactions 5-HTP Power by Nature's Sunshine Capsule 60 Capsule(s) View ingredients & interactions 5-HTP+Complex with Ashwagandha & L-Taurine by Purely Optimal Capsule 60 Veggie Capsule(s) View ingredients & interactions 7-Herb Energy by Banyan Botanicals Liquid 1 fl. Oz. · 30 mL View ingredients & interactions a Drenal by RLC Labs Capsule 120 Capsule(s) View ingredients & interactions A.J.'s Super Energy by Altrum Nutrition Capsule 60 Capsule(s) View ingredients & interactions A.J.'s Ultra Multi without Iron by Altrum Nutrition Tablet Or Pill 180 Tablet(s) View ingredients & interactions A.M. Activator by ProCaps Laboratories Capsule 180 Easy-To-Swallow Capsule(s) View ingredients & interactions A.M. Activator by ProCaps Laboratories Capsule 180 Easy-To-Swallow Capsule(s) View ingredients & interactions Absolute Cleanse by New Sun Capsule 140 Vegetarian Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Eleuthero: Common Questions

What is Eleuthero used for, and does it work?
People use Eleuthero for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Eleuthero for Genital herpes. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Eleuthero interact with prescription medications?
Yes. We list 1140 medications with a known interaction with Eleuthero. Use the checker above to see how Eleuthero interacts with a specific drug.
How are Eleuthero interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Eleuthero with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Eleuthero interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Eleuthero the same as ginseng?
No. Although it is often called 'Siberian ginseng,' Eleuthero is a different plant from true (Panax) ginseng. They share some traditional uses but are not closely related botanically.
What do people use Eleuthero for?
People most often use it to fight fatigue, boost energy and stamina, support focus, and help the body handle stress. The scientific evidence for these uses is limited and mixed.
Can I take Eleuthero during pregnancy or while breastfeeding?
It is best to avoid it. There is not enough reliable safety information for pregnant or breastfeeding people, so the cautious choice is to skip it and talk with your doctor.
Does Eleuthero have side effects?
Side effects are usually mild and may include trouble sleeping, jitteriness, headache, or stomach upset. Taking it earlier in the day may help reduce sleep problems.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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