Herb & supplement monograph

Rhodiola Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Rhodiola interacts with medications. The heart of this page is the interaction list — every drug Rhodiola is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Rhodiola is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Rhodiola Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Rhodiola drug interaction appears low for most people. None of Rhodiola's listed interactions are rated major, and they are split roughly evenly between moderate and minor concerns, most of them theoretical.

Interactions deserving the most attention

The best-documented interaction involves losartan, a blood pressure medicine: a small human study found rhodiola slowed how the body clears it, which could raise its levels and side effects. That same effect may extend to other medications cleared by the same enzyme. Because rhodiola may also lower blood sugar and blood pressure on its own, people taking diabetes medications or blood pressure drugs should watch for symptoms of levels dropping too low. Rhodiola may also stimulate the immune system, which could work against immunosuppressants, where steady drug effect really matters.

What the rest of the list means

A long interaction list does not mean every combination is risky. Most entries come from lab or animal research suggesting rhodiola might affect enzymes and transporters the body uses to process medications. Notably, human studies testing two of these predicted enzyme effects found no meaningful change, so many concerns remain theoretical.

Check your medications against Rhodiola

Based on HelloPharmacist’s Rhodiola interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Rhodiola

1271 medications have a known interaction with Rhodiola, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
6-mercaptopurinePurinethol
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + 6-mercaptopurine interaction 6-mercaptopurine drug page: uses, dosage & side effects
AbrocitinibCibinqo
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcalabrutinibCalquence
Moderate P-glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Read the full Rhodiola + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Rhodiola + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcebutololRhotral, Sectral
Moderate Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Read the full Rhodiola + Acebutolol interaction Acebutolol drug page: uses, dosage & side effects
Acetaminophen, IbuprofenCombogesic
Moderate Cytochrome P450 2c9 (cyp2c9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Read the full Rhodiola + Acetaminophen, Ibuprofen interaction
AcetazolamideAk-Zol, Diamox
Moderate Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Read the full Rhodiola + Acetazolamide interaction Acetazolamide drug page: uses, dosage & side effects
AcetohexamideDymelor
Moderate Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Rhodiola + Acetohexamide interaction
AdalimumabHumira
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Adalimumab interaction Adalimumab drug page: uses, dosage & side effects
Adalimumab-adazHyrimoz
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Adalimumab-adaz interaction
Adalimumab-adbmCyltezo
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Adalimumab-adbm interaction
Adalimumab-afzbAbrilada
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Adalimumab-afzb interaction
Adalimumab-attoAmjevita
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Adalimumab-atto interaction
Adalimumab-bwwdHadlima
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Adalimumab-bwwd interaction
Adalimumab-fkjpHulio
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Adalimumab-fkjp interaction
Aerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
Moderate Cytochrome P450 2c9 (cyp2c9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Read the full Rhodiola + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interaction
Afatinib DimaleateGilotrif
Moderate P-glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Read the full Rhodiola + Afatinib Dimaleate interaction Afatinib Dimaleate drug page: uses, dosage & side effects
AgomelatineValdoxan
Moderate Cytochrome P450 2c9 (cyp2c9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Read the full Rhodiola + Agomelatine interaction
AlbiglutideTanzeum
Moderate Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Rhodiola + Albiglutide interaction
AlefaceptAmevive
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Alefacept interaction
AlemtuzumabCampath
Moderate Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Read the full Rhodiola + Alemtuzumab interaction Alemtuzumab drug page: uses, dosage & side effects
AliskirenTekturna
Moderate Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Read the full Rhodiola + Aliskiren interaction Aliskiren drug page: uses, dosage & side effects
AlogliptinNesina
Moderate Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Rhodiola + Alogliptin interaction Alogliptin drug page: uses, dosage & side effects
Alogliptin, MetforminKazano
Moderate Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Rhodiola + Alogliptin, Metformin interaction
Alogliptin, PioglitazoneOseni
Moderate Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Rhodiola + Alogliptin, Pioglitazone interaction
AlvimopanEntereg
Moderate P-glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Read the full Rhodiola + Alvimopan interaction Alvimopan drug page: uses, dosage & side effects
AmbrisentanLetairis, Volibris
Moderate P-glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Read the full Rhodiola + Ambrisentan interaction Ambrisentan drug page: uses, dosage & side effects
AmilorideAmilamont, Midamor
Moderate Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Read the full Rhodiola + Amiloride interaction Amiloride drug page: uses, dosage & side effects
Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
Moderate Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.

Read the full Rhodiola + Amiloride, Hydrochlorothiazide interaction Amiloride, Hydrochlorothiazide drug page: uses, dosage & side effects
AmitriptylineElavil
Moderate Cytochrome P450 2c9 (cyp2c9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Read the full Rhodiola + Amitriptyline interaction Amitriptyline drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Rhodiola combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Rhodiola affects

Every type of medication (drug category) Rhodiola is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 10 drug categories Rhodiola interacts with
Antidiabetes DrugsAntihypertensive DrugsCytochrome P450 2c9 (cyp2c9) SubstratesImmunosuppressantsLosartan (cozaar)P-glycoprotein SubstratesAntidepressant DrugsCns DepressantsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 3a4 (cyp3a4) Substrates
Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Monograph

Rhodiola: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is limited and not strong. It is generally well tolerated for short-term use, but talk to your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Rhodiola
Scientific name
Rhodiola rosea
Family
Crassulaceae
Part used
Roots and rhizomes
Common forms
Capsules, tablets, extracts, tinctures, tea
People commonly use it for
  • Fatigue and low energy
  • Stress and coping (adaptogen)
  • Mental performance and focus
  • Mild depression
  • Physical and exercise performance

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated for short-term use, but long-term safety is not well studied.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Rhodiola (Rhodiola rosea) is a flowering plant that grows in cold, mountainous, and Arctic regions of Europe, Asia, and North America. It is also called golden root, arctic root, or king's crown. The root and underground stem (rhizome) are the parts used to make supplements.

Rhodiola has a long history of use in traditional medicine in Russia, Scandinavia, and parts of Asia. It is often called an adaptogen, a term used for herbs that are believed to help the body resist and adapt to physical, mental, and emotional stress. Today people take it most often to fight tiredness, support mood, and help with stress.

How it works

Rhodiola contains active compounds including rosavins and salidroside, and supplements are often standardized to a set amount of these. Many products list a ratio of about 3% rosavins to 1% salidroside, which is meant to mimic the natural plant.

Researchers think these compounds may affect chemical messengers in the brain such as serotonin, dopamine, and norepinephrine, which play a role in mood and energy. Rhodiola may also influence the body's stress-response system and cortisol levels. Most of these mechanisms come from laboratory and animal studies, so it is not fully clear how Rhodiola works in people.

Effectiveness

Does Rhodiola work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 20 uses evaluated
20 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Rhodiola, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 20 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Altitude sickness
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rhodiola is beneficial for altitude sickness.

Insufficient Reliable Evidence To Rate Anthracycline cardiotoxicity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rhodiola is beneficial for epirubicin-induced cardiotoxicity.

Insufficient Reliable Evidence To Rate Arrhythmia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for arrhythmia, there is insufficient reliable information about the clinical effects of rhodiola for this condition.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

The evidence related to the use of rhodiola for athletic performance is mixed, although specific standardized extracts might be beneficial for certain performance endpoints.

Insufficient Reliable Evidence To Rate Bladder cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for bladder cancer, there is insufficient reliable information about the clinical effects of rhodiola for this condition.

Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for CFS, there is insufficient reliable information about the clinical effects of rhodiola for this condition.

Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Rating & evidence shown verbatim from Natural Medicines

Oral rhodiola extract has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Depression
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rhodiola is beneficial for depression.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for diabetes, there is insufficient reliable information about the clinical effects of rhodiola for this condition.

Insufficient Reliable Evidence To Rate Fatigue
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research suggests that oral rhodiola extract decreases fatigue in stressful situations.

Insufficient Reliable Evidence To Rate Generalized anxiety disorder (GAD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rhodiola is beneficial for GAD.

Insufficient Reliable Evidence To Rate Hearing loss
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for hearing loss, there is insufficient reliable information about the clinical effects of rhodiola for this purpose.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for hyperlipidemia, there is insufficient reliable information about the clinical effects of rhodiola for this condition.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

Oral rhodiola has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Premature ejaculation
Rating & evidence shown verbatim from Natural Medicines

Oral rhodiola has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Premenstrual syndrome (PMS)
Rating & evidence shown verbatim from Natural Medicines

Oral rhodiola has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Sexual arousal
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for improving sexual arousal, there is insufficient reliable information about the clinical effects of rhodiola for this condition.

Insufficient Reliable Evidence To Rate Stress
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research suggests that oral rhodiola extract reduces feelings of stress.

Insufficient Reliable Evidence To Rate Tuberculosis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for tuberculosis, there is insufficient reliable information about the clinical effects of rhodiola for this condition.

Insufficient Reliable Evidence To Rate Upper respiratory tract infection (URTI)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rhodiola for URTI prevention, there is insufficient reliable information about the clinical effects of rhodiola for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Rhodiola appears to be reasonably safe for most healthy adults when used short-term, usually a few weeks. Its long-term safety has not been well studied.

Use extra caution if you have a mental health condition such as bipolar disorder, since stimulating herbs could potentially affect mood. People with low blood pressure or those undergoing surgery should also talk to a healthcare provider first.

Pregnancy and breastfeeding: There is not enough reliable safety information, so Rhodiola should be avoided if you are pregnant or breastfeeding.

Because supplements are not tightly regulated, product quality and strength can vary. Choose products from reputable brands, ideally with third-party testing, and always check with your pharmacist or doctor before starting.

Side effects

Rhodiola is usually well tolerated. When side effects occur, they are typically mild and may include:

  • Dizziness
  • Dry mouth
  • Trouble sleeping (especially if taken later in the day)
  • Jitteriness or feeling restless
  • Headache or stomach upset

Because it can feel stimulating for some people, taking it earlier in the day may help avoid sleep problems. Stop using it and contact a healthcare provider if you have an unusual or severe reaction.

Rhodiola: Reported Adverse Effects

Documented safety reports on Rhodiola from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, rhodiola seems to be well tolerated.

Most Common Adverse Effects:

Orally: Dizziness, increased or decreased production of saliva.

Reports by condition
Dry mouth Gastrointestinal

Orally, rhodiola extract may cause dry mouth or excessive saliva production.

  1. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
  2. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105.
Vertigo Neurologic/CNS

Orally, rhodiola extract can cause dizziness.

  1. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official, well-established dose for Rhodiola. Studies have used a range of amounts and different extract strengths, so it is hard to recommend one exact dose.

The best approach is to follow the directions on the product label and choose extracts standardized to rosavins and salidroside. Many people take it earlier in the day because it may be stimulating. Start with the lowest suggested dose and check with your pharmacist or doctor before starting, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Rhodiola & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Rhodiola & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 13 references that drive our Rhodiola monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
  4. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
  5. Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
  6. Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
  7. Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
  8. Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
  9. Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. PubMed
  10. Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31.
  11. Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Bio. 2016 Dec;54(12):3249-3256.
  12. Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016 Mar;72(3):295-300. PubMed
  13. Woron J, Siwek M. Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts. Psychiatr Pol 2018;52(6):983-96. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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Supplement products with Rhodiola

3,323 products in our database contain Rhodiola. Open any to see its full ingredient list and every drug interaction we check.

100% Natural Stress Regress by Whole Body Research Capsule 60 Vegetarian Capsule(s) View ingredients & interactions 3-Test-OXO by Legal Limit Labs Capsule 90 Capsule(s) View ingredients & interactions 4-Stress by Flora Capsule 60 Vegetarian Capsule(s) View ingredients & interactions 5-HTP Complex by Orzax Capsule 120 Vegetable Capsule(s) View ingredients & interactions 7-KETO LeanGels 100 mg by Protocol For Life Balance Softgel Capsule 60 Softgel(s) View ingredients & interactions 7-KETO LeanGels 100 mg by NOW Softgel Capsule 60 Softgel(s) View ingredients & interactions 7-KETO LeanGels 100 mg by NOW Softgel Capsule 120 Softgel(s) View ingredients & interactions 7-KETO LeanGels 100 mg by Protocol For Life Balance Softgel Capsule 60 Softgel(s) View ingredients & interactions 8 Immortals by Ron Teeguarden's Dragon Herbs Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions 8 Immortals by Ron Teeguarden's Dragon Herbs Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions 8 Immortals Drops by Ron Teeguarden's Dragon Herbs Liquid 60 Milliliter(s) · 2 Fluid Ounce(s) View ingredients & interactions a Drenal by RLC Labs Capsule 120 Capsule(s) View ingredients & interactions Acai QuickBurn by Vivid Health Nutrition Capsule 60 Capsule(s) View ingredients & interactions Active Adrenal by Rejuvica Health Liquid 2 Fluid Ounce(s) · 59 Milliliter(s) View ingredients & interactions Active Energy Complex by Sundown Organics Tablet Or Pill 30 Tablet(s) View ingredients & interactions Active Energy Mango Lemonade Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Peachy Mango Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Strawberry Lemonade Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Watermelon Wave Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Watermelon Wave Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions ActivNutrients Phyto by XYMOGEN Capsule 90 Vegetarian Capsule(s) View ingredients & interactions ActivNutrients Phyto by XYMOGEN Capsule 90 Vegetarian Capsule(s) View ingredients & interactions ACTS by TLS Weight Loss Solution Capsule 60 Capsule(s) View ingredients & interactions Adapt Adaptogen Extract by VAXA Liquid 60 mL View ingredients & interactions
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Rhodiola: Common Questions

What is Rhodiola used for, and does it work?
People use Rhodiola for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Rhodiola interact with prescription medications?
Yes. We list 1271 medications with a known interaction with Rhodiola. Use the checker above to see how Rhodiola interacts with a specific drug.
How are Rhodiola interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Rhodiola with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Rhodiola interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Rhodiola used for?
It is most often used to fight fatigue, support mood, and help the body cope with stress. It is considered an adaptogen, though the evidence for these uses is limited.
Is Rhodiola safe to take?
It is generally well tolerated for short-term use in healthy adults, but long-term safety isn't well studied. Check with your pharmacist or doctor before starting, especially if you have a health condition.
Can I take Rhodiola while pregnant or breastfeeding?
No reliable safety information is available, so it is best to avoid Rhodiola during pregnancy and breastfeeding.
When is the best time to take Rhodiola?
Many people take it earlier in the day because it can feel stimulating and may interfere with sleep if taken at night.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Rhodiola

A rotating sample of real supplements in our database that list Rhodiola — open any to see its full ingredients and every drug interaction we check.

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