Medication interaction hub

What Supplements Interact with Hydrocodone, Ibuprofen?

Hydrocodone, Ibuprofen brand name: Vicoprofen. Every interaction below applies to the brands too.

379 Interactions 13 Major 324 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrocodone, Ibuprofen? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrocodone, Ibuprofen against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Vicoprofen pairs hydrocodone, an opioid, with ibuprofen, an NSAID, which gives supplements two separate ways to cause trouble, and 13 of the 379 interactions on file are rated major, so this page deserves a careful read rather than a skim. The biggest patterns are bleeding and sedation: more than 200 of these ingredients can add to ibuprofen's effect on platelets and raise bleeding risk, while nearly 80, alcohol chief among them, deepen hydrocodone's drowsiness and, at the extreme, its dampening of breathing.

A wide middle band changes how the body handles the drug itself. Grapefruit can push hydrocodone levels up, St. John's wort can drop them, and a few botanicals strain the kidneys, an organ ibuprofen already works hard. The remaining entries are mostly moderate (324, with 42 minor), but start with the 13 majors, and mention unexpected bruising or heavy grogginess to your pharmacist promptly.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 324 Minor 42 No known interaction 1,073

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrocodone, Ibuprofen: Top Interactions at a Glance

The Hydrocodone, Ibuprofen supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 379 interacting ingredients — plus 1,073 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrocodone, Ibuprofen Combinations Today

The Hydrocodone, Ibuprofen + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible American Elder + Hydrocodone, Ibuprofeni

Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Reishi Mushroom + Hydrocodone, Ibuprofeni

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Gotu Kola + Hydrocodone, Ibuprofeni

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Bupleurum + Hydrocodone, Ibuprofeni

Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Lycopene + Hydrocodone, Ibuprofeni

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Probable Schisandra + Hydrocodone, Ibuprofeni

Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrocodone, Ibuprofen

All 1,452 ingredients in our database, ranked by severity — 379 with a Hydrocodone, Ibuprofen interaction on file and 1,073 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrocodone, Ibuprofen?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take American Elder with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Hydrocodone, Ibuprofen answer

Can you take Reishi Mushroom with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Full Reishi Mushroom + Hydrocodone, Ibuprofen answer

Can you take Gotu Kola with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Hydrocodone, Ibuprofen answer

Can you take Bupleurum with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Bupleurum + Hydrocodone, Ibuprofen answer

Can you take Lycopene with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Lycopene + Hydrocodone, Ibuprofen answer

Can you take Propolis with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.

Full Propolis + Hydrocodone, Ibuprofen answer

Can you take Pu-erh Tea with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pu-erh tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Pu-erh Tea + Hydrocodone, Ibuprofen answer

Can you take Puravive with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive contains quercetin, which has been shown in studies to mildly inhibit the CYP2C9 metabolizing enzyme.

Full Puravive + Hydrocodone, Ibuprofen answer

Can you take Purple Nut Sedge with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge inhibits platelet aggregation.

Full Purple Nut Sedge + Hydrocodone, Ibuprofen answer

Can you take Quercetin with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Full Quercetin + Hydrocodone, Ibuprofen answer

Can you take Rabdosia Rubescens with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Hydrocodone, Ibuprofen answer

Can you take Rauvolfia Vomitoria with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.

Full Rauvolfia Vomitoria + Hydrocodone, Ibuprofen answer

Can you take Rauwolscine with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Hydrocodone, Ibuprofen answer

Can you take Red Raspberry with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Red Raspberry + Hydrocodone, Ibuprofen answer

Can you take Resveratrol with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Hydrocodone, Ibuprofen answer

Can you take Rhodiola with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Full Rhodiola + Hydrocodone, Ibuprofen answer

Can you take Rhubarb with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Hydrocodone, Ibuprofen answer

Can you take Rooibos with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.

Full Rooibos + Hydrocodone, Ibuprofen answer

Can you take Rose Hip with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.

Full Rose Hip + Hydrocodone, Ibuprofen answer

Can you take Rosemary with Hydrocodone, Ibuprofen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Rosemary + Hydrocodone, Ibuprofen answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrocodone, Ibuprofen is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrocodone, Ibuprofen, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrocodone, Ibuprofen sits in 14 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Ibuprofen (Advil, Others) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Hydrocodone, Ibuprofen through this category.

Related: does Hydrocodone, Ibuprofen deplete any nutrients?

Hydrocodone, Ibuprofen has 1 reported nutrient association in the research literature — see the Hydrocodone, Ibuprofen nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrocodone, Ibuprofen

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrocodone, Ibuprofen.

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Pharmacist Counseling Corner

Hydrocodone, Ibuprofen & Supplements: Common Questions

What supplements interact with Hydrocodone, Ibuprofen?
In our interaction database, 379 supplement and herbal ingredients have an interaction with Hydrocodone, Ibuprofen on file — 13 rated major, 324 moderate, and 42 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Hydrocodone, Ibuprofen supplement interactions are the most serious?
The 13 major-rated combinations — led by Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrocodone, Ibuprofen?
That depends entirely on which supplement. The honest answer for Hydrocodone, Ibuprofen is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Vicoprofen have the same supplement interactions as Hydrocodone, Ibuprofen?
Yes — Vicoprofen all contain Hydrocodone, Ibuprofen, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrocodone, Ibuprofen deplete any vitamins or nutrients?
It might — Hydrocodone, Ibuprofen has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrocodone, Ibuprofen nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrocodone, Ibuprofen and my other medications?
This page covers Hydrocodone, Ibuprofen against supplements and herbal ingredients. Checking Hydrocodone, Ibuprofen against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.