Herb & supplement monograph

Reishi Mushroom Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Reishi Mushroom interacts with medications. The heart of this page is the interaction list — every drug Reishi Mushroom is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Reishi Mushroom is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reishi Mushroom Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Reishi Mushroom drug interaction appears low for most people, though a few medication groups deserve real attention. None of the listed interactions are rated major, and all rest on limited or theoretical evidence rather than well-documented human harm.

Interactions deserving the most attention

The strongest concern is with anticoagulant and antiplatelet drugs: at everyday amounts reishi does not seem to affect platelets, but higher doses do, so people on blood thinners have the most reason for caution about bleeding. Blood pressure medications also stand out, since reishi has lowered blood pressure in some, though not all, patients, and an added drop could matter for someone whose pressure is closely managed. With diabetes medications, animal research suggested a blood sugar effect, but studies in people with type 2 diabetes have not shown lower fasting glucose, making this a weaker concern.

What the rest of the list means

A long interaction list can look worrying, but here it mostly reflects a few theoretical mechanisms applied across hundreds of medications. In several cases, effects predicted from animal or lab research have not produced meaningful changes when actually studied in people.

Check your medications against Reishi Mushroom

Based on HelloPharmacist’s Reishi Mushroom interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Reishi Mushroom

375 medications have a known interaction with Reishi Mushroom, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AbciximabReoPro
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Abciximab interaction
AbrocitinibCibinqo
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.

Read the full Reishi Mushroom + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcebutololRhotral, Sectral
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Acebutolol interaction Acebutolol drug page: uses, dosage & side effects
AcenocoumarolSintrom
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Acenocoumarol interaction
Acetaminophen, AspirinGemnisyn
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, IbuprofenCombogesic
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Acetaminophen, Ibuprofen interaction
AcetazolamideAk-Zol, Diamox
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Acetazolamide interaction Acetazolamide drug page: uses, dosage & side effects
AcetohexamideDymelor
Moderate Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.

Read the full Reishi Mushroom + Acetohexamide interaction
Acetylsalicylic AcidEntrophen
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Acetylsalicylic Acid interaction Acetylsalicylic Acid drug page: uses, dosage & side effects
AlbiglutideTanzeum
Moderate Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.

Read the full Reishi Mushroom + Albiglutide interaction
AliskirenTekturna
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Aliskiren interaction Aliskiren drug page: uses, dosage & side effects
AlogliptinNesina
Moderate Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.

Read the full Reishi Mushroom + Alogliptin interaction Alogliptin drug page: uses, dosage & side effects
Alogliptin, MetforminKazano
Moderate Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.

Read the full Reishi Mushroom + Alogliptin, Metformin interaction
Alogliptin, PioglitazoneOseni
Moderate Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.

Read the full Reishi Mushroom + Alogliptin, Pioglitazone interaction
Alteplase, TpaActilyse, Activase
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Alteplase, Tpa interaction
Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interaction
Aluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interaction Aluminum Hydroxide, Aspirin, Magnesium Hydroxide drug page: uses, dosage & side effects
AmbrisentanLetairis, Volibris
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Ambrisentan interaction Ambrisentan drug page: uses, dosage & side effects
AmilorideAmilamont, Midamor
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Amiloride interaction Amiloride drug page: uses, dosage & side effects
Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Amiloride, Hydrochlorothiazide interaction Amiloride, Hydrochlorothiazide drug page: uses, dosage & side effects
AmlodipineNorliqva
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Amlodipine interaction Amlodipine drug page: uses, dosage & side effects
Amlodipine BenzoateKaterzia
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Amlodipine Benzoate interaction Amlodipine Benzoate drug page: uses, dosage & side effects
Amlodipine BesilateIstin
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Amlodipine Besilate interaction
Amlodipine BesylateNorvasc
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Amlodipine Besylate interaction Amlodipine Besylate drug page: uses, dosage & side effects
Amlodipine Besylate, BenazeprilLotrel
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Amlodipine Besylate, Benazepril interaction
Amlodipine, CelecoxibConsensi
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Amlodipine, Celecoxib interaction
Ammonium ChlorideAmmonium Chloride
Moderate Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Reishi Mushroom + Ammonium Chloride interaction
Anacaulase-bcdbNexoBrid
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full Reishi Mushroom + Anacaulase-bcdb interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Reishi Mushroom combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Reishi Mushroom affects

Every type of medication (drug category) Reishi Mushroom is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories Reishi Mushroom interacts with
Anticoagulant/antiplatelet DrugsAntidiabetes DrugsAntihypertensive Drugs
Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Monograph

Reishi Mushroom: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should not replace proven treatments. It is generally well tolerated for short-term use, but check with your pharmacist or doctor before starting, especially if you are pregnant, nursing, or take other medicines.

Reishi Mushroom
Scientific name
Ganoderma lucidum
Family
Ganodermataceae
Part used
Fruiting body, mycelium, and spores
Common forms
Capsules, tablets, powders, extracts, teas, and tinctures
People commonly use it for
  • Immune support
  • Fatigue and general well-being
  • Stress and sleep
  • Inflammation
  • Heart and cholesterol health

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated short-term, but long-term safety is not well studied.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Reishi (Ganoderma lucidum) is a tough, woody mushroom with a shiny, reddish-brown surface. It grows on trees in warm, humid parts of Asia, though much of what is sold today is cultivated commercially.

Reishi has been used in traditional Chinese and other Asian medicine for thousands of years. Because the raw mushroom is bitter and hard to eat, it is usually taken as a capsule, powder, extract, or tea. People take it for a wide range of reasons, most commonly to support the immune system and general well-being.

How it works

Reishi contains compounds that researchers believe may be responsible for its effects, including polysaccharides (such as beta-glucans) and triterpenes (such as ganoderic acids).

In laboratory and animal studies, these compounds appear to interact with immune cells and show antioxidant and anti-inflammatory activity. Triterpenes have also been studied for possible effects on cholesterol and blood pressure.

It is important to remember that most of this research is from test-tube or animal studies. What happens in a lab does not always carry over to real benefits in people, so these mechanisms remain largely theoretical.

Effectiveness

Does Reishi Mushroom work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 31 uses evaluated
1 Leans ineffective 30 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Ineffective Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical studies show that oral reishi mushroom does not improve lipid levels in patients with hyperlipidemia or type 2 diabetes.

Also studied for 30 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aging
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for aging, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Altitude sickness
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for altitude sickness, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Alzheimer disease
Rating & evidence shown verbatim from Natural Medicines

A small clinical study suggests that oral reishi mushroom does not improve Alzheimer disease symptoms.

Insufficient Reliable Evidence To Rate Asthma
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for asthma, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral reishi mushroom is beneficial for athletic performance in sedentary adults.

Insufficient Reliable Evidence To Rate Benign prostatic hyperplasia (BPH)
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research suggests that oral reishi mushroom extract can help reduce some lower urinary tract symptoms in patients with BPH.

Insufficient Reliable Evidence To Rate Bronchitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for bronchitis, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Cancer-related fatigue
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral reishi mushroom is beneficial in patients with breast cancer and fatigue.

Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral reishi mushroom is beneficial for reducing CVD risk factors.

Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for CFS, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Chronic kidney disease (CKD)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for CKD, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Colorectal adenoma
Rating & evidence shown verbatim from Natural Medicines

Limited clinical research suggests that oral reishi mushroom extract may be beneficial for reducing colorectal adenoma size.

Insufficient Reliable Evidence To Rate Coronary heart disease (CHD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral reishi mushroom is beneficial for CHD.

Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using reishi mushroom for COVID-19, there is insufficient reliable information about the clinical effects of reishi mushromm for this purpose.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Evidence on the use of oral reishi mushroom in patients with type 2 diabetes is conflicting.

Insufficient Reliable Evidence To Rate Fibromyalgia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral reishi mushroom is beneficial for fibromyalgia.

Insufficient Reliable Evidence To Rate Genital herpes
Rating & evidence shown verbatim from Natural Medicines

Oral reishi mushroom has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Gulf war syndrome
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral reishi mushroom is beneficial for Gulf war syndrome.

Insufficient Reliable Evidence To Rate Hepatitis B
Rating & evidence shown verbatim from Natural Medicines

One small clinical study suggests that a specific reishi mushroom extract may reduce hepatitis B activity and improve liver function.

Insufficient Reliable Evidence To Rate Herpes labialis (cold sores)
Rating & evidence shown verbatim from Natural Medicines

Oral reishi mushroom has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Herpes zoster (shingles)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for herpes zoster, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Human papillomavirus (HPV)
Rating & evidence shown verbatim from Natural Medicines

Oral reishi mushroom has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Limited research suggests that oral reishi mushroom may be beneficial in some types of hypertension.

Insufficient Reliable Evidence To Rate Influenza
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using reishi mushroom for influenza, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using reishi mushroom for insomnia, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Lung cancer
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral reishi mushroom does not reduce the size of lung tumors.

Insufficient Reliable Evidence To Rate Peptic ulcers
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for peptic ulcers, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Insufficient Reliable Evidence To Rate Psychological well-being
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral reishi mushroom is beneficial for improving psychological well-being.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Oral reishi mushroom has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Stress
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral reishi mushroom for stress, there is insufficient reliable information about the clinical effects of reishi mushroom for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Reishi is generally considered well tolerated when taken by mouth for a few months. However, its long-term safety has not been carefully studied.

People with bleeding disorders or who are scheduled for surgery should be cautious, since reishi may affect blood clotting. Those with low blood pressure should also use care. If you have a serious health condition or take prescription medicines, talk to your pharmacist or doctor first.

Because there is not enough safety information, reishi should be avoided during pregnancy and breastfeeding. Choose products from reputable brands, as supplements are not tightly regulated and quality can vary.

Side effects

Most people tolerate reishi well, but possible side effects include upset stomach, dizziness, dry mouth, nosebleeds, and skin rash or itching.

There have been rare reports of liver problems, especially with powdered reishi products. Stop using it and seek medical care if you notice yellowing of the skin or eyes, dark urine, severe belly pain, or unusual tiredness. If you have any allergic reaction, such as trouble breathing or swelling, stop and get help right away.

Reishi Mushroom: Reported Adverse Effects

Documented safety reports on Reishi Mushroom from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, reishi mushroom is generally well tolerated.

Most Common Adverse Effects:

Orally: Dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Reports by condition
Allergic rhinitis (hay fever) Pulmonary/Respiratory

Respiratory allergy to reishi spores can occur. Sore throat and runny nose have also been reported.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  3. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  4. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
Cluster headache Neurologic/CNS

Orally, reishi mushroom can cause dizziness. Other rare symptoms include insomnia and headache.

  1. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  2. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  3. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
Diarrhea Gastrointestinal

Orally, reishi mushroom can cause dryness of the mouth, throat, or nasal cavity, nausea, stomach upset, and, more rarely, diarrhea.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  3. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  4. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520.
Hepatitis Hepatic

One case of hepatotoxicity and one case of fatal fulminant hepatitis have been reported in patients who had used reishi mushroom powder for 1-2 months. There is a case report of a 61-year-old male with hypereosinophilia associated with hepatic nodules following the use of reishi mushroom powder for about 2 months. Symptoms resolved after discontinuation of the product. Although these side effects were thought to be associated with the use of reishi mushroom powder, it is unclear if other factors played a role. The patient had been taking tegafur, gimeracil, and oteracil potassium for about 4 months following anterior resection for rectal adenocarcinoma but discontinued these agents and initiated reishi mushroom due to liver injury.

  1. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  2. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.
Pruritus Dermatologic

Orally, reishi mushroom can cause itching, rash, and other skin reactions.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized dose for reishi. Doses vary a lot depending on whether you use the whole mushroom, a powder, or a concentrated extract.

The best approach is to follow the directions on the product label and not exceed them. A pharmacist can help you decide if a product and dose are appropriate for you. If you notice any side effects, stop and check with a healthcare professional.

Pregnancy & Breastfeeding

Reishi Mushroom & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using

Reishi Mushroom & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 17 references that drive our Reishi Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
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  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Reishi Mushroom

587 brands in our database make a supplement containing Reishi Mushroom.

Product directory

Supplement products with Reishi Mushroom

2,873 products in our database contain Reishi Mushroom. Open any to see its full ingredient list and every drug interaction we check.

Active Energy Peachy Mango Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Strawberry Lemonade Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Watermelon Wave Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Watermelon Wave Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Hexose Correlated Compound by Fresh Nutrition Capsule 90 Capsule(s) View ingredients & interactions Active Immunity by Akasha Naturals Tablet Or Pill 90 Tablet(s) View ingredients & interactions Active Seniors Unflavored by All One Powder 16.2 oz. · 460 Gram(s) View ingredients & interactions Adam's Vitality by Logos Nutritionals Capsule 90 Capsule(s) View ingredients & interactions AdaptaMax by Nature's Sunshine Capsule 100 Capsule(s) View ingredients & interactions Adaptogen Chocolate Dream by MN Morphogen Nutrition Powder 7.71 Ounce(s) · 216 Gram(s) View ingredients & interactions Adaptogen Vanilla Cream by MN Morphogen Nutrition Powder 7.71 oz · 216 g View ingredients & interactions Adaptogenic by Anima Mundi Liquid 4 Ounce(s) · 113 Gram(s) View ingredients & interactions Adaptogenic Potion by SuperSmart Liquid 120 mL View ingredients & interactions Adaptostym by Professional Botanicals Capsule 60 Veg. Capsule(s) View ingredients & interactions ADR Complex by Professional Botanicals Capsule 60 Veg. Capsule(s) View ingredients & interactions Adrenal 100 Cortex 75 by Professional Botanicals Capsule 90 Capsule(s) View ingredients & interactions Adrenal AdaptEnz by ProEnzol Capsule 60 Vegan Capsule(s) View ingredients & interactions Adrenal AdaptEnz by ProEnzol Capsule 120 Vegan Capsule(s) View ingredients & interactions Adrenal Complex by Professional Botanicals Capsule 60 Veg. Capsule(s) View ingredients & interactions Adrenal Cortisol Support Complex by California Academy of Health Capsule 90 Capsule(s) View ingredients & interactions Adrenal Cortisol Support with Relora by Protocol For Life Balance Capsule 90 Veg Capsule(s) View ingredients & interactions Adrenal Cortisol Support with Relora by Protocol For Life Balance Capsule 90 Veg Capsule(s) View ingredients & interactions Adrenal Energy Support by Douglas Cooper Co. Capsule 90 Veg Capsule(s) View ingredients & interactions Adrenal Lover by Bioray Adult Daily Liquid 60 mL · 2 Fluid Ounce(s) View ingredients & interactions
Pharmacist Counseling Corner

Reishi Mushroom: Common Questions

What is Reishi Mushroom used for, and does it work?
People use Reishi Mushroom for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Reishi Mushroom interact with prescription medications?
Yes. We list 375 medications with a known interaction with Reishi Mushroom. Use the checker above to see how Reishi Mushroom interacts with a specific drug.
How are Reishi Mushroom interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Reishi Mushroom with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Reishi Mushroom interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Reishi Mushroom used for?
People most commonly use reishi to support the immune system, ease fatigue, reduce stress, and promote general well-being. Strong human evidence for these uses is limited, so it should not replace proven treatments.
Is Reishi Mushroom safe to take?
It is generally well tolerated for short-term use in most healthy adults, but long-term safety is not well studied and rare liver problems have been reported. Check with your pharmacist or doctor before starting, especially if you have a health condition.
Can I take reishi while pregnant or breastfeeding?
No—there is not enough safety information, so reishi is best avoided during pregnancy and breastfeeding.
How do I take Reishi Mushroom?
Reishi is usually taken as a capsule, powder, extract, or tea since the raw mushroom is bitter and woody. Follow the product label, as there is no standard dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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