Herb & supplement monograph

Uva Ursi Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Uva Ursi interacts with medications. The heart of this page is the interaction list — every drug Uva Ursi is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Uva Ursi is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Uva Ursi Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Uva Ursi drug interaction appears low for most people. None of the listed interactions are rated major, and nearly all rest on lab findings that have not been confirmed in people.

Interactions deserving the most attention

The interaction that deserves the most attention involves lithium, a medication with a narrow safety margin. Uva ursi may act as a mild diuretic, and diuretics can cause the kidneys to hold on to more lithium, which could raise lithium levels. It is also worth knowing that urinary acidifying agents may work against uva ursi itself, since the herb seems to work best in alkaline urine, so combining them could blunt any urinary benefit you are taking it for.

What the rest of the list means

The long list of moderate interactions looks more worrisome than it is. Most of these entries come from broad drug categories flagged because lab studies suggest uva ursi might affect enzymes or transport proteins the body uses to clear many medications. These effects have not been reported in humans, and in one case the predicted effect did not even appear in animal studies.

Check your medications against Uva Ursi

Based on HelloPharmacist’s Uva Ursi interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Uva Ursi

804 medications have a known interaction with Uva Ursi, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Uva Ursi using our pharmacist-reviewed interaction data.

AI summaries are generated from our Uva Ursi interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Uva Ursi combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Uva Ursi affects

Every type of medication (drug category) Uva Ursi is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 6 drug categories Uva Ursi interacts with

Cytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesGlucuronidated DrugsLithiumUrinary Acidifying AgentsP-glycoprotein Substrates

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.