Herb & supplement monograph

Lithium Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Lithium interacts with medications. The heart of this page is the interaction list — every drug Lithium is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Lithium is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Lithium Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Lithium drug interaction is meaningful for many people, so this supplement deserves more caution than most. Roughly half of the listed interactions are rated major, the rest are moderate, and none are minor.

Interactions deserving the most attention

The strongest human-supported concerns are with diuretics and serotonergic drugs such as SSRIs. Diuretics, especially thiazide and loop types, can slow the body's removal of lithium, which may raise lithium levels and side effects. Combining lithium with serotonergic medicines has been linked to serotonin syndrome, and lithium may also mask its warning signs. Common pain relievers called NSAIDs can likewise reduce how well the kidneys clear lithium.

What the rest of the list means

Many of the other listed interactions are theoretical or come from experience with prescription-strength lithium, and it is often unclear whether the smaller amounts in lithium supplements would cause the same effects in people. Even so, lithium levels depend on how the kidneys handle it and on the body's sodium balance, which is why so many blood pressure and mood medicines appear on this list.

Check your medications against Lithium

Based on HelloPharmacist’s Lithium interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Lithium

515 medications have a known interaction with Lithium, graded by severity. Select any drug for the full evidence-based detail.

259 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Lithium.

2,830 drugs
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Major Diuretic Drugs

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.

Read the full Lithium + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Chlorpheniramine, Pseudoephedrine interaction
Acetaminophen, DextromethorphanTylenol Cough Ex Strength
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Dextromethorphan interaction
Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction
Acetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, MeperidineDemerol APAP
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Meperidine interaction
Acetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
Major Diuretic Drugs

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.

Read the full Lithium + Acetaminophen, Pamabrom, Pyrilamine interaction
Acetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Acetaminophen, Phenylephrine, Chlorpheniramine interaction
AcetazolamideAk-Zol, Diamox
Major Diuretic Drugs

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.

Read the full Lithium + Acetazolamide interaction Acetazolamide drug page: uses, dosage & side effects
AlmotriptanAlmogran, Axert
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Almotriptan interaction Almotriptan drug page: uses, dosage & side effects
AlosetronLotronex
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Alosetron interaction Alosetron drug page: uses, dosage & side effects
Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
Major Diuretic Drugs

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.

Read the full Lithium + Amiloride, Hydrochlorothiazide interaction Amiloride, Hydrochlorothiazide drug page: uses, dosage & side effects
AmitriptylineElavil
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Amitriptyline interaction Amitriptyline drug page: uses, dosage & side effects
Amitriptyline, ChlordiazepoxideLimbitrol DS
Major Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full Lithium + Amitriptyline, Chlordiazepoxide interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Lithium combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Lithium affects

Every type of medication (drug category) Lithium is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 11 drug categories Lithium interacts with
Diuretic DrugsSerotonergic DrugsAce Inhibitors (aceis)AnticonvulsantsAntipsychotic DrugsCalcium Channel BlockersMethyldopa (aldomet)MethylxanthinesNonsteroidal Anti-inflammatory Drugs (nsaids)PhenothiazinesSkeletal Muscle Relaxants
Diuretic Drugs

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Thiazide diuretics and loop diuretics might reduce lithium excretion, particularly in sodium-restricted patients. If lithium is clinically indicated and other treatment options are unavailable or inadequate in patients using diuretics, lithium treatment can be initiated with extreme caution. Serum lithium should be measured frequently and the doses used should be the lowest dose ordinarily tolerated. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
In a case report, a 67-year-old female with depression and bipolar disorder using lithium in combination with selective serotonin reuptake inhibitors (SSRIs) and other medications developed serotonin syndrome with symptoms of deep tendon hyperreflexia, muscle rigidity, tremor, and hyperthermia. However, agitation, one classical symptom of serotonin syndrome, was lacking. This was thought to be due to masking by lithium toxicity. Lithium can increase serotonin levels, thus, combining serotonergic drugs with lithium might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Ace Inhibitors (Aceis)

Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Concomitant administration of ACEIs with lithium may increase lithium concentrations. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Anticonvulsants

Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.
Drugs such as carbamazepine and phenytoin seem to increase the risk of neurotoxicity. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Encephalopathic syndrome has been reported in multiple patients taking prescription lithium and antipsychotics concomitantly. Symptoms have included weakness and lethargy, fever, confusion, and extrapyramidal symptoms. In some patients, resulting brain damage was irreversible. Although there is no established causal relationship between these symptoms and the combination of lithium and antipsychotic medications, there is a theoretical relationship. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, taking lithium supplements with calcium channel blockers might reduce lithium levels and might also increase the risk of certain adverse effects.
Calcium channel blockers might reduce lithium concentrations. Monitor lithium levels with concurrent use. Calcium channel blockers might also increase the adverse neurological and gastrointestinal adverse effects of lithium. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Methyldopa (Aldomet)

Theoretically, taking lithium supplements with methyldopa might increase the risk of lithium toxicity.
Concurrent use of methyldopa with lithium increases the risk of lithium toxicity. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Methylxanthines

Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Xanthines such as aminophylline, caffeine, and theophylline (Theo-Dur, Theo-24, others) might increase the clearance of lithium. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
NSAIDs can decrease the renal clearance of lithium and increase lithium levels. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Phenothiazines

Theoretically, taking lithium supplements with phenothiazines might decrease the levels and clinical effects of phenothiazines.
Concomitant use of lithium with phenothiazines might reduce lithium concentrations. Lithium might also reduce phenothiazine concentrations, making the pharmacokinetic effect unpredictable. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Lithium might prolong neuromuscular blockade. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Monograph

Lithium: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipolar disorder. Low-dose supplement forms like lithium orotate are sold for mood support, but there is very little reliable evidence that they work, and even small amounts of lithium can be risky for some people. Always talk to a pharmacist or doctor before taking any lithium product.

Lithium
Part used
Mineral element (not a plant); various lithium salts
Common forms
Capsules, tablets (lithium orotate, lithium aspartate in supplements; lithium carbonate and citrate as prescription drugs)
People commonly use it for
  • Mood support
  • Bipolar disorder (prescription)
  • Healthy mental function
  • Irritability or stress
  • Sleep support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Lithium has a narrow safety margin and prescription forms require blood monitoring; supplement forms are not well studied.

PregnancyPossibly Unsafe

When lithium carbonate and lithium citrate are used orally. Lithium can cause fetal toxicity and increases the risk for cardiac and other abnormalitie...

Read the full pregnancy detail
BreastfeedingLikely Unsafe

When used orally. Lithium is secreted into breast milk and may cause adverse effects in the nursing infant. Prescription lithium may be used in circum...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Lithium is a soft, silvery-white metal and a natural chemical element (atomic number 3). It is found in tiny amounts in rocks, soil, drinking water, and many foods, so most people take in small amounts every day through their diet.

In medicine, lithium is best known as a prescription drug. Forms such as lithium carbonate and lithium citrate are FDA-approved to treat bipolar disorder and are among the oldest and most studied mood-stabilizing medicines.

Lithium also appears in dietary supplements, usually in much lower doses and in different forms like lithium orotate or lithium aspartate. These are marketed for general mood and mental wellness, but they are not the same as the carefully dosed and monitored prescription versions.

How it works

Scientists do not fully understand exactly how lithium works in the brain. It is thought to affect several brain chemical messengers (such as serotonin and dopamine) and to influence signaling pathways inside brain cells.

Lab and animal research suggests lithium may also protect nerve cells and affect enzymes and proteins involved in mood and brain cell health. Many of these ideas are based on laboratory or animal studies and may not directly apply to the low doses found in supplements.

Effectiveness

Does Lithium work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 24 uses evaluated
24 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Lithium, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 24 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Alcohol use disorder
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for alcohol use disorder, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Alzheimer disease
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral low-dose lithium is beneficial for preventing cognitive decline associated with Alzheimer disease.

Insufficient Reliable Evidence To Rate Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for ALS, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Anorexia nervosa
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for anorexia nervosa, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Asthma
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for asthma, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Attention deficit-hyperactivity disorder (ADHD)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for ADHD, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Autism spectrum disorder
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for autism spectrum disorder, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Bipolar disorder
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for bipolar disorder, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Bulimia nervosa
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for bulimia nervosa, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for cancer, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Cognitive impairment
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for cognitive impairment, there is insufficient reliable information about the clinical effects of lithium supplements for this purpose.

Insufficient Reliable Evidence To Rate Cyclic vomiting syndrome (CVS)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for CVS, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Depression
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for depression, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for diabetes, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Epilepsy
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for epilepsy, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Headache
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for headache, there is insufficient reliable information about the clinical effects of lithium supplements for this purpose.

Insufficient Reliable Evidence To Rate Huntington disease
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for Huntington disease, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Hyperthyroidism
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for hyperthyroidism, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Meniere disease
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for Meniere disease, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Parkinson disease
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for mania associated with levodopa treatment in patients with Parkinson disease, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Schizophrenia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for schizophrenia, as well as neutropenia related to antipsychotic use in patients with schizophrenia, there is insufficient reliable information about the clinical effects of lithium supplements for these conditions.

Insufficient Reliable Evidence To Rate Seborrheic dermatitis
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical lithium for seborrheic dermatitis, there is insufficient reliable information about the clinical effects of lithium for this condition.

Insufficient Reliable Evidence To Rate Tardive dyskinesia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for tardive dyskinesia, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Insufficient Reliable Evidence To Rate Tourette syndrome
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral lithium supplements for Tourette syndrome, there is insufficient reliable information about the clinical effects of lithium supplements for this condition.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Lithium has a narrow safety margin, which means the difference between a helpful amount and a harmful amount can be small. With prescription lithium, doctors regularly check blood levels along with kidney and thyroid function.

People with kidney problems, thyroid disease, heart conditions, or those who are dehydrated should be especially careful. Salt intake and fluid balance can change how much lithium stays in the body.

Pregnancy: Lithium crosses the placenta and has been linked to heart and other birth defects. Avoid lithium during pregnancy unless a doctor decides the benefits outweigh the risks and monitors you closely.

Breastfeeding: Lithium passes into breast milk and may build up in a nursing baby. Avoid it while breastfeeding unless directed and supervised by a doctor.

Even supplement forms like lithium orotate are not fully studied for safety, and high or repeated doses could potentially cause lithium to build up. Always check with a pharmacist or doctor first.

Side effects

Common side effects of lithium can include nausea, stomach upset, diarrhea, increased thirst, frequent urination, hand tremor, weight gain, and feeling tired or foggy.

Over the long term, lithium can affect the thyroid and kidneys, so monitoring is important with prescription use.

Lithium toxicity is a medical emergency. Warning signs include severe tremor, confusion, slurred speech, vomiting, severe diarrhea, unsteady walking, drowsiness, or seizures. If these occur, seek emergency care right away. Because supplement labels may not warn about this, it is important to take any lithium product seriously.

Lithium: Reported Adverse Effects

Documented safety reports on Lithium from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, prescription forms of lithium are generally well tolerated when used as prescribed. Plasma levels must be monitored to avoid toxicity. It is unclear how the lower doses of lithium found in supplements may alter the occurrence and likelihood of these adverse effects.

Most Common Adverse Effects:

Orally: Edema, fatigue, fine tremor, gastrointestinal symptoms, lethargy, muscle weakness, polydipsia, polyuria, skin conditions, vertigo, and weight gain.

Reports by condition
Acne Dermatologic

Orally, lithium can cause or exacerbate skin disorders such as hair loss, acne, psoriasis, and rash. A case of Stevens-Johnson syndrome is also reported in a patient with bipolar disorder who took lithium carbonate at an unknown dose for 17 days.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017812s028,018421s027lbl.pdf. Accessed Nov. 21, 2018
  4. Itoh M, Fukuya Y, Endo C, et al. Lithium carbonate-induced Stevens-Johnson syndrome: the first case report. Int J Dermatol 2023;62(3):e165-e167.
Bipolar disorder Psychiatric

Abrupt discontinuation of lithium resulting in a rapid reduction in serum lithium levels can precipitate recurrence of bipolar symptoms. Lithium should be tapered gradually over at least 14 days.

  1. Perlis RH, Sachs GS, Lafer B, et al. Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry 2002;159:1155-9..
Bipolar disorder Other

Orally, chronic use of lithium has been reported to cause an irreversible reduction in taste and smell in a patient with bipolar disorder who took 400-1000 mg/day for 4 months. Chronic use of lithium 1200 mg/day has also been reported to cause dysphagia in a 17-year-old patient with bipolar disorder; however, the patient's serum lithium level was in the toxic range and the adverse effect resolved once the level normalized. It is unclear if these effects would occur with the smaller doses found in lithium supplements.

  1. Nombora O, Samico A, Venâncio Â. Lithium-Induced Dysgeusia and Hyposmia: A Case Report and a Literature Review. Clin Neuropharmacol 2023;46(1):31-33.
  2. Aydin D, Tural Hesapcioglu S, Ceylan MF. Oropharyngeal Dysphagia as a Clinical Presentation of Lithium Intoxication: A Case Report. J Am Acad Child Adolesc Psychiatry 2021;60(12):1443-1445.
Bipolar disorder Cardiovascular

Orally, lithium has been reported to cause bradyarrhythmia. A case of symptomatic bradycardia due to sinoatrial node dysfunction is reported in a patient with bipolar disorder who took lithium orotate 20 mg daily for 5 years, despite a serum lithium level in the therapeutic range. Deep vein thrombosis is also reported in 2 patients with bipolar disorder who experienced toxic serum levels of lithium. It is unclear if these effects are a concern with the smaller doses found in lithium supplements.

  1. Sarangi A, Javed S, Paul T, Amor W. Lithium-Induced Sinoatrial Node Dysfunction. Cureus 2021;13(7):e16778.
  2. Sogawa R, Tobita S, Monji A, et al. Deep Vein Thrombosis after Lithium Toxicity: A Report of Two Cases and Literature Review. Case Rep Psychiatry 2021;2021:9934037.
Bipolar disorder Neurologic/CNS

Orally, lithium can cause vertigo, muscle weakness, lethargy, fatigue, and a dazed feeling. These adverse effects often improve with continued use. Fine tremor can occur and may persist with continued use. Chronic use of lithium can cause mild cognitive and memory impairment, particularly in the presence of dehydration or hyponatremia. These long-term neurological adverse effects of lithium are potentially due to accumulation in the central nervous system even when blood levels appear within the therapeutic range. Lithium-associated hyperparathyroidism-induced hypercalcemia has resulted in hallucinations, confusion, insomnia, and agitation. A case of delirium and transient difficulty with word finding is reported in a patient with bipolar disorder treated with lithium 250-500 mg twice daily and 9 sessions of electroconvulsive therapy. A case of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is also reported in a patient with bipolar disorder who had a toxic lithium level of 1.94 mEq/L. It is unclear if these effects would occur with the smaller doses found in lithium supplements.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Foulser P, Abbasi Y, Mathilakath A, Nilforooshan R. Do not treat the numbers: lithium toxicity. BMJ Case Rep. 2017;2017. pii: bcr-2017-220079.
  4. Benjelloun R, Motaib I, Otheman Y. Lithium-associated hypercalcemia presenting with neuropsychiatric manifestations in a patient with bipolar disorder. Case Rep Psychiatry. 2020;2020:6630838.
  5. Yang Q, Cheng X, Su Z, Sun L, Li M. Electroconvulsive therapy combined with lithium developed reversible pure anomic aphasia: a case report. BMC Psychiatry 2022;22(1):663.
  6. Ono R, Nishiguchi S, Kitagawa I. Lithium intoxication-associated mild encephalitis/encephalopathy with a reversible splenial lesion: A case report. Bipolar Disord 2022;24(5):551-552.
Diabetes Renal

Orally, lithium can cause polyuria, polydipsia, and edema. Chronic lithium use has been reported to cause central or nephrogenic diabetes insipidus, hypocalciuric hypercalcemia, and nephrotic syndrome. Long-term lithium use is estimated to increase the odds of chronic kidney disease (CKD) by at least 2-fold and may contribute to CKD progression. It is unclear if these effects would occur with the smaller doses found in lithium supplements.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Hanna RM, Hasnain H, Sangalang MD, et al. Three Patients with Lithium-Associated Hyperparathyroidism: Literature Review Regarding Medical and Surgical Management. Case Rep Nephrol Dial. 2019;9(2):108-118.
  3. Nwabufor PC, Omoniyi ON, Oyibo SO. A Case of Lithium-Associated Hypocalciuric Hypercalcemia. Cureus. 2020;12(9):e10606.
  4. Zhang P, Gandhi H, Kassis N. Lithium-induced nephropathy; One medication with multiple side effects: a case report. BMC Nephrol 2022;23(1):309.
  5. Li JJ, Tan S, Kawashita T, Tagle CA, Farmand F. Central Diabetes Insipidus in the Background of Lithium Use: Consider Central Causes Despite Nephrogenic as the Most Common. Am J Case Rep 2023;24:e939034.
  6. Kawada T. Lithium use and the risk of chronic kidney disease. Basic Clin Pharmacol Toxicol 2023;132(4):295-296.
  7. Bocchetta A, Ambrosiani L, Sanna F, et al. Renal function at follow-up in a cohort of patients who had shown reduced glomerular filtration rate during long-term treatment with lithium. J Nephrol 2023;36(4):1079-1081.
Diabetes Endocrine

Orally, chronic use of lithium has been reported to cause various endocrine disorders. Case reports associate chronic lithium use with hypothyroidism, hyperthyroidism, goiter, hyperparathyroidism, and diabetes insipidus. In one case report, a 68-year-old male with schizophrenia developed severe hypothyroidism resulting in myxedema coma after taking oral lithium carbonate. He recovered after discontinuation of lithium and administration of levothyroxine. At least two other cases of lithium-associated myxedema coma have been reported. At least 4 cases of lithium-associated hyperparathyroidism have been reported in females aged 53-68 years that had taken lithium for 24 years or more. These patients presented with hypernatremia, hypercalcemia, elevated serum creatinine, thyroid or parathyroid abnormalities, and nephrogenic diabetes insipidus. It is unclear if these effects are a concern with the smaller doses found in lithium supplements.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Rauf A, Gul S, Nasir M, Arif U, Oyenuga M. A Rare Case of Lithium-induced Partial Nephrogenic Diabetes Insipidus. Cureus. 2020;12(4):e7877.
  4. Hanna RM, Hasnain H, Sangalang MD, et al. Three Patients with Lithium-Associated Hyperparathyroidism: Literature Review Regarding Medical and Surgical Management. Case Rep Nephrol Dial. 2019;9(2):108-118.
  5. Rana P, Alba Aponte P, Babar G. An Adolescent Female with Bipolar Disorder Presenting with Lithium-Induced Hyperthyroidism. Case Rep Endocrinol. 2020;2020:1283464.
  6. Nwabufor PC, Omoniyi ON, Oyibo SO. A Case of Lithium-Associated Hypocalciuric Hypercalcemia. Cureus. 2020;12(9):e10606.
  7. Yamada Y, Fujiwara M, Tsujino S, et al. Late-Onset Neutropenia With Clozapine Associated With Lithium Carbonate-Related Hyperthyroidism: A Case Report. J Clin Psychopharmacol 2023;43(1):76-77.
  8. Sawagashira R, Sasagawa Y, Matsukura M, Takamaru Y. Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. Psychiatry Clin Neurosci. 2018;72(2):131.
  9. Benjelloun R, Motaib I, Otheman Y. Lithium-associated hypercalcemia presenting with neuropsychiatric manifestations in a patient with bipolar disorder. Case Rep Psychiatry. 2020;2020:6630838.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established, well-tested dose for low-dose lithium supplements, and product strengths vary widely between brands. If you use a supplement, follow the label directions and do not take more than recommended.

Prescription lithium doses are individualized by a doctor and adjusted using blood tests; these should never be guessed at or self-managed.

Because lithium can be harmful at the wrong amount, talk to a pharmacist or doctor before starting any lithium product, especially if you have a health condition or take other medicines.

Pregnancy & Breastfeeding

Lithium & Pregnancy

Possibly Unsafe

When lithium carbonate and lithium citrate are used orally. Lithium can cause fetal toxicity and increases the risk for cardiac and other abnormalities, including neural tube and urethral defects. However, it does not seem to increase the risk for preterm birth or low birth rate. Some research suggests lithium might increase the risk for spontaneous abortion. Based on a meta-analysis of 2 population studies, taking lithium during pregnancy may increase the risk for spontaneous abortion when compared with the general population, but not when compared with patients with affective disorders not taking lithium during pregnancy. This suggests that it may be the presence of affective disorder itself, or the possible associated use of other teratogenic drugs or substances during pregnancy, which may increase the risk for spontaneous abortion. When the potential benefits to the mother and child outweigh the possible risk to the fetus, prescription lithium may be used with close monitoring by a healthcare professional. The safety of lithium supplements during pregnancy is unknown.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Pinelli JM, Symington AJ, Cunningham KA, Paes BA. Case report and review of the perinatal implications of maternal lithium use. Am J Obstet Gynecol 2002;187:245-9..
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017812s028,018421s027lbl.pdf. Accessed Nov. 21, 2018
  4. Fornaro M, Maritan E, Ferranti R, et al. Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes. Am J Psychiatry. 2020;177(1):76-92.

Lithium & Breastfeeding

Likely Unsafe

When used orally. Lithium is secreted into breast milk and may cause adverse effects in the nursing infant. Prescription lithium may be used in circumstances when the potential maternal benefits outweigh the possible risk to the infant. The infant should be closely monitored for signs of lithium toxicity.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017812s028,018421s027lbl.pdf. Accessed Nov. 21, 2018
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 26 references that drive our Lithium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Perlis RH, Sachs GS, Lafer B, et al. Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry 2002;159:1155-9.. PubMed
  4. Pinelli JM, Symington AJ, Cunningham KA, Paes BA. Case report and review of the perinatal implications of maternal lithium use. Am J Obstet Gynecol 2002;187:245-9.. PubMed
  5. Sawagashira R, Sasagawa Y, Matsukura M, Takamaru Y. Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. Psychiatry Clin Neurosci. 2018;72(2):131. PubMed
  6. Foulser P, Abbasi Y, Mathilakath A, Nilforooshan R. Do not treat the numbers: lithium toxicity. BMJ Case Rep. 2017;2017. pii: bcr-2017-220079. PubMed
  7. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017812s028,018421s027lbl.pdf. Accessed Nov. 21, 2018
  8. Fornaro M, Maritan E, Ferranti R, et al. Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes. Am J Psychiatry. 2020;177(1):76-92. DOI
  9. Rauf A, Gul S, Nasir M, Arif U, Oyenuga M. A Rare Case of Lithium-induced Partial Nephrogenic Diabetes Insipidus. Cureus. 2020;12(4):e7877. PubMed
  10. Hanna RM, Hasnain H, Sangalang MD, et al. Three Patients with Lithium-Associated Hyperparathyroidism: Literature Review Regarding Medical and Surgical Management. Case Rep Nephrol Dial. 2019;9(2):108-118. PubMed
  11. Rana P, Alba Aponte P, Babar G. An Adolescent Female with Bipolar Disorder Presenting with Lithium-Induced Hyperthyroidism. Case Rep Endocrinol. 2020;2020:1283464. PubMed
  12. Nwabufor PC, Omoniyi ON, Oyibo SO. A Case of Lithium-Associated Hypocalciuric Hypercalcemia. Cureus. 2020;12(9):e10606. PubMed
  13. Landa E, Wagner S, Makkar A, Liu A, Jung D. An atypical presentation of serotonin syndrome. Cureus. 2021;13(2):e13377. PubMed
  14. Benjelloun R, Motaib I, Otheman Y. Lithium-associated hypercalcemia presenting with neuropsychiatric manifestations in a patient with bipolar disorder. Case Rep Psychiatry. 2020;2020:6630838. PubMed
  15. Nombora O, Samico A, Venâncio Â. Lithium-Induced Dysgeusia and Hyposmia: A Case Report and a Literature Review. Clin Neuropharmacol 2023;46(1):31-33. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Lithium

103 brands in our database make a supplement containing Lithium.

Product directory

Supplement products with Lithium

332 products in our database contain Lithium. Open any to see its full ingredient list and every drug interaction we check.

Lithium (Orotate) 5 mg by Pure Encapsulations Capsule 90 Capsule(s) View ingredients & interactions Lithium (Orotate) 5 mg by Pure Encapsulations Capsule 180 Capsule(s) View ingredients & interactions Lithium 1,000 mcg by Life Extension Capsule 100 Vegetarian Capsule(s) View ingredients & interactions Lithium 1,000 mcg by Life Extension Capsule 100 Vegetarian Capsule(s) View ingredients & interactions Lithium Aspartate 5 mg by Swanson Premium Brand Capsule 100 Capsule(s) View ingredients & interactions Lithium Aspartate 5 mg by Solaray Capsule 100 VegCap(s) View ingredients & interactions Lithium Aspartate 5 mg by Solaray Capsule 100 VegCap(s) View ingredients & interactions Lithium Liquid by Pure Encapsulations Liquid 30 mL · 1 fl. Oz. View ingredients & interactions Lithium Liquid by Pure Encapsulations Liquid 30 mL · 1 fl. Oz. View ingredients & interactions Lithium Orotate by Ortho Molecular Products Capsule 60 Capsule(s) View ingredients & interactions Lithium Orotate by Global Healing Center Capsule 60 Capsule(s) View ingredients & interactions Lithium Orotate by NHC Natural Healthy Concepts Capsule 60 Capsule(s) View ingredients & interactions Lithium Orotate by Klaire Labs Capsule 120 Capsule(s) View ingredients & interactions Lithium Orotate by Global Healing Capsule 60 Capsule(s) View ingredients & interactions Lithium Orotate by Vitamin Research Products Capsule 120 Capsule(s) View ingredients & interactions Lithium Orotate 10 mg by Weyland Brain Nutrition Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Lithium Orotate 10 mg by Weyland Brain Nutrition Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Lithium Orotate 10 mg by AgeImmune Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Lithium Orotate 1000 mcg by Weyland Brain Nutrition Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Lithium Orotate 120 mg by Advanced Research Tablet Or Pill 200 Tablet(s) View ingredients & interactions Lithium Orotate 120 mg by Advanced Research Tablet Or Pill 100 Tablet(s) View ingredients & interactions Lithium Orotate 2.5 mg by Weyland Brain Nutrition Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Lithium Orotate 20 by Weyland Brain Nutrition Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Lithium Orotate 250 mg by Super-Nutrition Capsule 90 Vegetarian Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Lithium: Common Questions

What is Lithium used for, and does it work?
People use Lithium for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Lithium interact with prescription medications?
Yes. We list 515 medications with a known interaction with Lithium, including 259 rated major. Use the checker above to see how Lithium interacts with a specific drug.
How are Lithium interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Lithium with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Lithium interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Lithium orotate the same as prescription Lithium?
No. Lithium orotate is a supplement form that usually contains a much smaller amount of Lithium and is not FDA-approved or monitored. Prescription Lithium carbonate or citrate is carefully dosed and requires blood testing under a doctor's care.
What is Lithium used for?
Prescription Lithium is mainly used to treat bipolar disorder and is strongly proven to help. Low-dose supplements are marketed for mood and mental wellness, but the evidence that they work is very weak.
Is it safe to take a Lithium supplement on my own?
It is not clearly safe. Lithium has a narrow margin between helpful and harmful amounts, supplement forms are not well studied, and certain people are at higher risk. Always check with a pharmacist or doctor first.
Can I take Lithium if I am pregnant or breastfeeding?
Lithium is generally avoided during pregnancy and breastfeeding because it can reach the baby and has been linked to birth defects. Do not use it during these times unless a doctor directs and monitors you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Lithium

A rotating sample of real supplements in our database that list Lithium — open any to see its full ingredients and every drug interaction we check.

See all 332 products with Lithium →
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