Herb & supplement monograph

Peppermint Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Peppermint interacts with medications. The heart of this page is the interaction list — every drug Peppermint is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Peppermint is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Peppermint Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Peppermint drug interaction appears low for most people. None of the listed interactions are rated major, and nearly all rest on lab or animal findings rather than confirmed effects in people.

Interactions deserving the most attention

The best-documented concern involves medications the body clears through a specific liver enzyme that peppermint oil can slow. In a human study, a single dose of peppermint oil raised blood levels of felodipine, a blood pressure medication processed this way. Animal research also suggests peppermint oil could raise levels of cyclosporine, a transplant medication where even small level changes matter, though this has not been reported in people. These deserve the closest attention.

What the rest of the list means

Peppermint's long list of interacting medications looks daunting, but most entries are theoretical, based on lab studies showing peppermint may affect enzymes the body uses to clear many drugs. In several cases the predicted effect has not appeared in humans; for example, peppermint tea did not meaningfully change how people processed caffeine. A long list here mostly reflects possibilities, not proven problems.

Check your medications against Peppermint

Based on HelloPharmacist’s Peppermint interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Peppermint

796 medications have a known interaction with Peppermint, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Ado-trastuzumab Emtansine interaction Ado-trastuzumab Emtansine drug page: uses, dosage & side effects
AbemaciclibVerzenio
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Abemaciclib interaction Abemaciclib drug page: uses, dosage & side effects
Abiraterone
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Abiraterone interaction Abiraterone drug page: uses, dosage & side effects
Abiraterone AcetateYonsa, Zytiga
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Abiraterone Acetate interaction Abiraterone Acetate drug page: uses, dosage & side effects
AbrocitinibCibinqo
Moderate Cytochrome P450 2c9 (cyp2c9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.

Read the full Peppermint + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcalabrutinibCalquence
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Chlorpheniramine, Pseudoephedrine interaction
Acetaminophen, DextromethorphanTylenol Cough Ex Strength
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Dextromethorphan interaction
Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Read the full Peppermint + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Peppermint combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Peppermint affects

Every type of medication (drug category) Peppermint is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Peppermint interacts with
Cyclosporine (neoral, Sandimmune)Cytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesCytochrome P450 1a2 (cyp1a2) Substrates
Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Monograph

Peppermint: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartburn and is not recommended in concentrated oil form for infants and young children. Check with your pharmacist or doctor before using it regularly, especially during pregnancy or breastfeeding.

Peppermint
Scientific name
Mentha x piperita
Family
Lamiaceae
Part used
Leaves and essential oil
Common forms
Tea, capsules (including enteric-coated peppermint oil), essential oil, tincture, topical creams
People commonly use it for
  • Irritable bowel syndrome (IBS)
  • Indigestion and gas
  • Nausea
  • Tension headache (topical oil)
  • Colds and congestion
  • Freshening breath

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Peppermint tea and culinary use are generally safe, but concentrated oil should be used carefully.

PregnancyLikely Safe

When used orally in amounts commonly found in foods. There is insufficient information available about the safety of using peppermint in medicinal amo...

Read the full pregnancy detail
BreastfeedingLikely Safe

When used orally in amounts commonly found in foods. There is insufficient information available about the safety of using peppermint in medicinal amo...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Peppermint is a fragrant perennial herb from the mint family (Lamiaceae). It is actually a natural cross between watermint and spearmint, and it is now grown around the world. It is native to Europe and Asia and is easily recognized by its cool, minty smell and spear-shaped leaves.

People use peppermint in many ways. The leaves are brewed into tea, used in cooking, and added to candies and personal care products. The essential oil, which is pressed or distilled from the plant, is used in capsules, topical products, and aromatherapy. In supplements aimed at digestion, peppermint oil is often placed in an enteric-coated capsule so it travels further down the gut before being released.

How it works

The main active ingredient in peppermint oil is menthol. Menthol can relax the smooth muscle of the gut wall, which may explain why peppermint oil can ease cramping and pain in IBS. This muscle-relaxing effect is also thought to help with gas and bloating.

Menthol creates a cooling sensation by acting on temperature-sensing nerve receptors in the skin and mucous membranes, which is why peppermint feels refreshing and may give a mild numbing or soothing feeling. Laboratory studies also suggest peppermint compounds may have antioxidant and germ-fighting properties.

It is important to remember that many of these mechanisms come from test-tube and animal research. These findings help explain how peppermint might work, but they do not prove it will treat a specific condition in people.

Effectiveness

Does Peppermint work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 37 uses evaluated
1 Likely effective 6 Possibly effective 30 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Likely Effective Irritable bowel syndrome (IBS)
Rating & evidence shown verbatim from Natural Medicines

Oral enteric-coated peppermint oil is conditionally recommended by the American College of Gastroenterology (ACG) for the relief of global IBS symptoms, such as abdominal pain.

Possibly Effective Barium enema-related colonic spasm
Rating & evidence shown verbatim from Natural Medicines

Rectal peppermint, as part of barium enema preparations, seems to reduce colonic spasms during examination. Oral peppermint also seems to be beneficial.

Possibly Effective Chemotherapy-induced nausea and vomiting (CINV)
Rating & evidence shown verbatim from Natural Medicines

Oral and inhaled peppermint seem to reduce nausea and vomiting in patients with CINV.

Possibly Effective Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Oral peppermint, in combination with caraway and possibly other ingredients, seems to reduce symptoms of dyspepsia. It is unclear if oral peppermint alone is beneficial.

Possibly Effective Endoscopy-associated adverse effects
Rating & evidence shown verbatim from Natural Medicines

Intraluminal peppermint seems to reduce spasticity during an endoscopy. It is unclear if oral peppermint is beneficial for reducing adverse effects related to endoscopy.

Possibly Effective Nipple fissures
Rating & evidence shown verbatim from Natural Medicines

Topical peppermint seems to reduce cracked skin and pain in the nipples due to breastfeeding.

Possibly Effective Pressure ulcers
Rating & evidence shown verbatim from Natural Medicines

Topical peppermint seems to reduce the risk of pressure ulcers.

Also studied for 30 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Abdominal pain
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral peppermint for abdominal pain, there is insufficient reliable information about the clinical effects of peppermint for this condition.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral peppermint oil is beneficial for athletic performance.

Insufficient Reliable Evidence To Rate Breast cancer-related hot flashes
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical peppermint is beneficial for reducing hot flashes in patients with breast cancer.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaled peppermint oil is beneficial for improving cognitive function.

Insufficient Reliable Evidence To Rate Common cold
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral, topical, or inhaled peppermint for the common cold, there is insufficient reliable information about the clinical effects of peppermint for this condition.

Insufficient Reliable Evidence To Rate Dental plaque
Rating & evidence shown verbatim from Natural Medicines

Topical peppermint has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Diffuse esophageal spasm
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral peppermint oil is beneficial for diffuse esophageal spasm.

Insufficient Reliable Evidence To Rate Dysmenorrhea
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral peppermint oil is beneficial for reducing menstrual pain.

Insufficient Reliable Evidence To Rate Fatigue
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaled peppermint oil improves fatigue in patients with cardiac disease.

Insufficient Reliable Evidence To Rate Halitosis
Rating & evidence shown verbatim from Natural Medicines

Peppermint has only been evaluated in combination with other ingredients as a mouthwash; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaled peppermint oil is beneficial for insomnia.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaled peppermint oil is beneficial for menopausal symptoms.

Insufficient Reliable Evidence To Rate Migraine headache
Rating & evidence shown verbatim from Natural Medicines

It is unclear if intranasal or inhaled peppermint oil is beneficial for migraine headache.

Insufficient Reliable Evidence To Rate Mosquito repellent
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical peppermint oil as a mosquito repellent, there is insufficient reliable information about the clinical effects of peppermint for this purpose.

Insufficient Reliable Evidence To Rate Myalgia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical peppermint oil for myalgia, there is insufficient reliable information about the clinical effects of peppermint for this condition.

Insufficient Reliable Evidence To Rate Oral mucositis
Rating & evidence shown verbatim from Natural Medicines

Topical peppermint has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical peppermint oil for osteoarthritis, there is insufficient reliable information about the clinical effects of peppermint for this condition.

Insufficient Reliable Evidence To Rate Postherpetic neuralgia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical peppermint oil for postherpetic neuralgia, there is insufficient reliable information about the clinical effects of peppermint for this condition.

Insufficient Reliable Evidence To Rate Postoperative ileus
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral peppermint oil is beneficial for the prevention of postoperative ileus.

Insufficient Reliable Evidence To Rate Postoperative nausea and vomiting (PONV)
Rating & evidence shown verbatim from Natural Medicines

Some preliminary clinical studies suggest that inhaled peppermint may be beneficial for PONV. However, it is unclear if the benefit is due to aromatherapy or improved breathing patterns.

Insufficient Reliable Evidence To Rate Postoperative pain
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaled peppermint oil is beneficial for postoperative pain.

Insufficient Reliable Evidence To Rate Postoperative recovery
Rating & evidence shown verbatim from Natural Medicines

Inhaled peppermint has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Postoperative sleep disturbance
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaled peppermint oil is beneficial for postoperative sleep disturbance.

Insufficient Reliable Evidence To Rate Pre-procedural anxiety
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaled peppermint oil is beneficial for reducing anxiety prior to a medical procedure.

Insufficient Reliable Evidence To Rate Pregnancy-induced nausea and vomiting
Rating & evidence shown verbatim from Natural Medicines

Inhaled peppermint oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Pruritus
Rating & evidence shown verbatim from Natural Medicines

Some preliminary clinical studies suggest that topical peppermint oil improves itching of various etiologies.

Insufficient Reliable Evidence To Rate Small intestinal bacterial overgrowth (SIBO)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral peppermint for SIBO, there is insufficient reliable information about the clinical effects of peppermint for this condition.

Insufficient Reliable Evidence To Rate Stress
Rating & evidence shown verbatim from Natural Medicines

It is unclear if inhaled peppermint oil is beneficial for stress.

Insufficient Reliable Evidence To Rate Toothache
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical peppermint oil for toothache, there is insufficient reliable information about the clinical effects of peppermint for this condition.

Insufficient Reliable Evidence To Rate Urticaria
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical peppermint oil for urticaria, there is insufficient reliable information about the clinical effects of peppermint for this condition.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Peppermint tea and the amounts used in food are generally considered safe for most adults. Concentrated peppermint oil is stronger and should be used with more care. People with gastroesophageal reflux disease (GERD) or frequent heartburn may find that peppermint makes their symptoms worse, because it can relax the muscle between the stomach and esophagus.

People with hiatal hernia or known gallstones should talk to a healthcare provider before using peppermint supplements. Never put peppermint oil directly under the nose or on the face of infants and young children, as menthol can cause serious breathing problems.

For pregnancy, peppermint tea in normal food amounts is likely fine, but concentrated oil and supplements have not been well studied, so it is safest to avoid them unless your provider approves. For breastfeeding, information is limited, so avoid concentrated peppermint supplements and check with your doctor or pharmacist first.

Side effects

Peppermint is usually well tolerated. The most common side effect of peppermint oil capsules is heartburn or a burning feeling. Enteric-coated capsules are designed to reduce this. Some people may also notice burping with a minty taste, nausea, or a burning sensation when going to the bathroom.

Applied to the skin, peppermint oil can cause irritation, redness, or allergic rash in some people, especially if it is not diluted. Rarely, people may have an allergic reaction. Swallowing large amounts of concentrated peppermint oil can be dangerous, so always follow product directions and keep essential oils out of reach of children.

Peppermint: Reported Adverse Effects

Documented safety reports on Peppermint from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, topically, or rectally, peppermint oil is generally well tolerated. Inhaled,

peppermint oil seems to be well tolerated. Intranasally, no adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted. Orally, peppermint leaf seems to be well tolerated.

Most Common Adverse Effects:

Orally: Abdominal pain, anal burning, belching, diarrhea, dry mouth, heartburn, nausea, and vomiting.

Topically: Burning, dermatitis, irritation, and redness.

Reports by condition
Asthma Immunologic

One case of IgE-mediated anaphylaxis, characterized by sudden onset of lip and tongue swelling, tightness of throat, and shortness of breath, has been reported in a 69-year-old male who consumed peppermint candy. An allergic reaction after use of peppermint oil in combination with caraway oil has been reported in a patient with a history of bronchial asthma. It is not clear if this reaction occurred in response to the peppermint or caraway components.

  1. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. Allergy Asthma Clin Immunol. 2014;10(1):6.
  2. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2
Burns Dermatologic

Topically, peppermint oil can cause skin irritation, burning, erythema, and contact dermatitis. Also, a case of severe mucosal injury has been reported for a patient who misused an undiluted over the counter mouthwash that contained peppermint and arnica oil in 70% alcohol.

In large amounts, peppermint oil may cause chemical burns when used topically or orally. A case of multiple burns in the oral cavity and pharynx, along with edema of the lips, tongue, uvula, and soft palate, has been reported for a 49-year-old female who ingested 40 drops of pure peppermint oil. Following treatment with intravenous steroids and antibiotics, the patient's symptoms resolved over the course of 2 weeks. Also, a case of chemical burns on the skin and skin necrosis has been reported for a 35-year-old male who spilled undiluted peppermint oil on a previous skin graft. Oral peppermint oil has also been associated with burning mouth syndrome and chronic mouth ulceration in people with contact sensitivity to peppermint. Also, excessive consumption of mint candies containing peppermint oil has been linked to cases of stomatitis.

  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8.
  2. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2.
  3. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198.
  4. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629.
  5. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365.
  6. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58.
  7. Tran, A., Pratt, M., and DeKoven, J. Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. Dermatitis 2010;21(2):111-115.
  8. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clin Cosmet Investig Dermatol 2016;9:333-8.
  9. Wu J, Xu R, Zhan R, et al. Effective symptomatic treatment for severe and intractable pruritus associated with severe burn-induced hypertrophic scars: A prospective, multicenter, controlled trial. Burns 2016;42(5):1059-66.
  10. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  11. Tamir, S., Davidovich, Z., Attal, P., and Eliashar, R. Peppermint oil chemical burn. Otolaryngol.Head Neck Surg. 2005;133(5):801-802.
  12. Parys, B. T. Chemical burns resulting from contact with peppermint oil mar: a case report. Burns Incl.Therm.Inj. 1983;9(5):374-375.
  13. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4.
  14. Rogers SN, Pahor AL. A form of stomatitis induced by excessive peppermint consumption. Dent Update 1995;22:36-7.
Cluster headache Neurologic/CNS

Orally, headache has been reported rarely.

  1. Weerts ZZRM, Masclee AAM, Witteman BJM, et al. Efficacy and safety of peppermint oil in a randomized, double-blind trial of patients with irritable bowel syndrome. Gastroenterology. 2020;158(1):123-136.
Diarrhea Gastrointestinal

Orally, peppermint oil can cause heartburn, nausea and vomiting, anal or perianal burning, abdominal pain, belching, dry mouth, diarrhea, and increased appetite. Enteric-coated capsules might help to reduce the incidence of heartburn. However, in one clinical study, a specific enteric-coated formulation of peppermint oil (Pepogest; Nature's Way) taken as 180 mg three times daily was associated with a higher rate of adverse effects when compared with placebo (48% versus 31%, respectively). Specifically, of the patients consuming this product, 11% experienced belching and 26% experienced heartburn, compared to 2% and 12%, respectively, in the placebo group. A meta-analysis of eight small clinical studies in patients with irritable bowel syndrome shows that taking enteric-coated formulations of peppermint oil increases the risk of gastroesophageal reflux symptoms by 67% when compared with a control group. Enteric-coated capsules can also cause anal burning in people with reduced bowel transit time.

  1. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5.
  2. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  3. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  4. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3.
  5. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7.
  6. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6.
  7. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8.
  8. Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6.
  9. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig.Dis.Sci. 2010;55(5):1385-1390.
  10. Hitz, Lindenmuller, I and Lambrecht, J. T. Oral care. Curr Probl.Dermatol 2011;40:107-115.
  11. Shavakhi, A., Ardestani, S. K., Taki, M., Goli, M., and Keshteli, A. H. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. Acta Gastroenterol Belg 2012;75(3):349-353.
  12. Lech, Y., Olesen, K. M., Hey, H., Rask-Pedersen, E., Vilien, M., and Ostergaard, O. [Treatment of irritable bowel syndrome with peppermint oil. A double- blind study with a placebo]. Ugeskr.Laeger 10-3-1988;150(40):2388-2389.
  13. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2
  14. Cash BD, Epstein MS, Shah SM. A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms. Dig Dis Sci 2016;61(2):560-71.
  15. Weerts ZZRM, Masclee AAM, Witteman BJM, et al. Efficacy and safety of peppermint oil in a randomized, double-blind trial of patients with irritable bowel syndrome. Gastroenterology. 2020;158(1):123-136.
  16. Nee J, Ballou S, Kelley JM, et al. Peppermint Oil Treatment for Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial. Am J Gastroenterol 2021;116(11):2279-2285.
  17. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8.
  18. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8.
  19. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3.
  20. Ingrosso MR, Ianiro G, Nee J, et al. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. Aliment Pharmacol Ther 2022;56(6):932-41.
  21. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717.
Fatigue Hepatic

One case of hepatocellular liver injury has been reported following the oral use of peppermint. Symptoms included elevated liver enzymes, fatigue, jaundice, dark urine, and signs of hypersensitivity. Details on the dosage and type of peppermint consumed were unavailable.

  1. Douros A, Bronder E, Andersohn F, et al. Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study. Int J Mol Sci 2016;17(1).
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single official dose for peppermint, and the right amount depends on the form and the reason you are using it. For IBS, products usually come as standardized enteric-coated peppermint oil capsules with directions on the label. Teas are made by steeping the dried leaves in hot water.

Because product strength varies widely, the best approach is to follow the directions on your specific product and not to exceed the recommended amount. Concentrated essential oil should never be swallowed unless it is in a product made for that purpose. Always check with your pharmacist or doctor before starting peppermint supplements, especially if you have a health condition or take other medicines.

Pregnancy & Breastfeeding

Peppermint & Pregnancy

Likely Safe

When used orally in amounts commonly found in foods. There is insufficient information available about the safety of using peppermint in medicinal amounts during pregnancy or lactation; avoid using.

  1. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clin Cosmet Investig Dermatol 2016;9:333-8.

Peppermint & Breastfeeding

Likely Safe

When used orally in amounts commonly found in foods. There is insufficient information available about the safety of using peppermint in medicinal amounts during pregnancy or lactation; avoid using.

  1. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clin Cosmet Investig Dermatol 2016;9:333-8.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 41 references that drive our Peppermint monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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Super Colon Cleanse Powder by Health Plus Powder 12 oz. · 340 g · 34 Serving(s) Off market View ingredients & interactions Super Colon Cleanse Powder by Health Plus Powder 12 oz. · 340 Gram(s) Off market View ingredients & interactions Super Colon Cleanse Powder by Health Plus Powder 12 oz. · 340 Gram(s) Off market View ingredients & interactions Super EPA Complex by Thorne FX Softgel Capsule 120 Gelcap(s) Off market View ingredients & interactions Super Mushroom by Natural Factors Whole Earth & Sea Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions Super Mushroom by Natural Factors Whole Earth & Sea Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions Supercritical Antioxidants by New Chapter Softgel Capsule 60 Hexane-Free Softgel Capsule(s) Off market View ingredients & interactions Supercritical Antioxidants by New Chapter Softgel Capsule 60 Softgel(s) Off market View ingredients & interactions Supercritical Diet & Energy by New Chapter Tablet Or Pill 60 Vegetarian Tablet(s) Off market View ingredients & interactions SuperFoods Supreme Mixed Berry by GNC Earth Genius Powder 22.22 Oz(s) · 630 Gram(s) Off market View ingredients & interactions SuperFoods Supreme Mixed Berry by GNC Earth Genius Powder 22.22 Oz(s) · 630 Gram(s) Off market View ingredients & interactions SuperFoods Supreme Vanilla Chai by GNC Earth Genius Powder 23.28 Oz(s) · 660 Gram(s) Off market View ingredients & interactions SuperFoods Supreme Vanilla Chai by GNC Earth Genius Powder 23.28 Oz(s) · 660 Gram(s) Off market View ingredients & interactions Superzymes by Vitamin Discount Center Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Superzymes by Vitamin Discount Center Tablet Or Pill 180 Tablet(s) Off market View ingredients & interactions SvG by Loomis Enzymes Capsule 180 Capsule(s) Off market View ingredients & interactions Tablet by The Pathway To Healing Tablet Or Pill Off market View ingredients & interactions Termo Burn with Erythopure by Hamilton Healthcare Platinum Series Capsule 90 Capsule(s) Off market View ingredients & interactions TerraZyme by doTERRA DigestZen Capsule 90 Vegetable Capsule(s) Off market View ingredients & interactions TerraZyme by doTERRA DigestZen Capsule 90 Vegetable Capsule(s) Off market View ingredients & interactions The Brain Ultimate Focus by The Brain Capsule 30 Vegetarian Capsule(s) Off market View ingredients & interactions The Essential Prenatal Ultra Softgels by OLLY Softgel Capsule 60 Softgel(s) Off market View ingredients & interactions Thera Zinc Spray Peppermint Clove Flavor by Quantum Health Liquid 2 fl. Oz. · 60 mL Off market View ingredients & interactions Thera-Colon Cleanse by Body Dynamics MaXzorb Nutrition Capsule 90 Vegetable Capsule(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Peppermint: Common Questions

What is Peppermint used for, and does it work?
People use Peppermint for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Peppermint for Irritable bowel syndrome (IBS), Barium enema-related colonic spasm, Chemotherapy-induced nausea and vomiting (CINV) and Dyspepsia. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Peppermint interact with prescription medications?
Yes. We list 796 medications with a known interaction with Peppermint. Use the checker above to see how Peppermint interacts with a specific drug.
How are Peppermint interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Peppermint with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Peppermint interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Does Peppermint really help with IBS?
Enteric-coated Peppermint oil capsules have some of the strongest herbal evidence for easing IBS symptoms like belly pain and bloating in certain people. It does not work for everyone, so talk to your provider about whether it is right for you.
Can Peppermint cause heartburn?
Yes. Peppermint can relax the muscle between the stomach and esophagus, which may worsen heartburn or reflux in some people. Enteric-coated capsules are designed to lower this risk.
Is Peppermint tea safe to drink every day?
For most healthy adults, Peppermint tea in normal amounts is generally considered safe to enjoy regularly. If you have reflux, gallbladder problems, or are pregnant, check with your pharmacist or doctor first.
Is Peppermint oil safe for children?
Peppermint essential oil should never be applied near the face or nose of infants and young children because menthol can cause serious breathing problems. Ask a pediatrician before giving any Peppermint product to a child.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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