Herb & supplement monograph

Beet Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Beet interacts with medications. The heart of this page is the interaction list — every drug Beet is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Beet is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Beet Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Beet drug interaction appears low for most people. None of beet's interactions are rated major, and the moderate ratings rest on lab research rather than effects proven in people.

Interactions deserving the most attention

The biggest group is CYP3A4 substrates, medications cleared by a particular liver enzyme; a beet pigment blocked this enzyme in lab tests, so beet could in theory raise levels of these drugs, but this has not been shown in humans. With blood pressure medications, beet's natural nitrates can relax blood vessels, though human studies are mixed and one found concentrated beetroot juice did not meaningfully change blood pressure or heart rate. People whose blood pressure medicine is closely adjusted are the ones for whom even a small added effect could matter.

What the rest of the list means

Beet's long list of interacting medications reflects a few shared mechanisms applied across many drugs, not hundreds of separate proven problems. Most entries are theoretical, based on possible effects on enzymes the body uses to process medications, and the best human data so far has not shown clinically meaningful changes.

Check your medications against Beet

Based on HelloPharmacist’s Beet interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Beet

861 medications have a known interaction with Beet, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Ado-trastuzumab Emtansine interaction Ado-trastuzumab Emtansine drug page: uses, dosage & side effects
AbemaciclibVerzenio
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Abemaciclib interaction Abemaciclib drug page: uses, dosage & side effects
Abiraterone
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Abiraterone interaction Abiraterone drug page: uses, dosage & side effects
Abiraterone AcetateYonsa, Zytiga
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Abiraterone Acetate interaction Abiraterone Acetate drug page: uses, dosage & side effects
AcalabrutinibCalquence
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acalabrutinib interaction Acalabrutinib drug page: uses, dosage & side effects
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Chlorpheniramine, Pseudoephedrine interaction
Acetaminophen, DextromethorphanTylenol Cough Ex Strength
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Dextromethorphan interaction
Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
Moderate Cytochrome P450 3a4 (cyp3a4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full Beet + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Beet combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Beet affects

Every type of medication (drug category) Beet is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories Beet interacts with
Cytochrome P450 3a4 (cyp3a4) SubstratesAntihypertensive DrugsCytochrome P450 1a2 (cyp1a2) Substrates
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Monograph

Beet: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but supplement effects are modest and not a substitute for prescribed treatment, so talk with your pharmacist or doctor before relying on it.

Beet
Scientific name
Beta vulgaris
Family
Amaranthaceae
Part used
Root and leaves (greens)
Common forms
Juice, powder, capsules, tablets, whole food, concentrated shots, gels
People commonly use it for
  • High blood pressure
  • Exercise and athletic performance
  • Heart and circulation support
  • General antioxidant/anti-inflammatory support
  • Liver and digestive support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

Beet is widely eaten as a food and is generally well tolerated for most adults.

PregnancyUse caution

Beet as a food is fine, but concentrated supplements lack safety data, so use caution.

BreastfeedingInsufficient reliable information

There is insufficient reliable information available about the safety of beets used medicinally during pregnancy and breast-feeding.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Beet (Beta vulgaris) is a root vegetable that has been eaten for centuries and is grown in many parts of the world. The deep-red beetroot is the most familiar form, but the leafy green tops are also edible and nutritious. Beets are related to chard and spinach.

As a supplement, beet is most often sold as beetroot juice or beetroot powder, sometimes standardized by its nitrate content. People take it hoping to support healthy blood pressure, improve exercise performance, and provide antioxidants. It is also a popular natural food coloring.

How it works

Beets are rich in dietary nitrate. In the body, nitrate can be converted into nitric oxide, a molecule that helps relax and widen blood vessels. This may improve blood flow and slightly lower blood pressure, and it may help muscles use oxygen more efficiently during exercise.

Beets also contain betalains (the pigments that give them their red or yellow color), along with vitamins, minerals, and other plant compounds that have antioxidant properties in laboratory studies. Much of the detail about how these compounds work in people is still being studied.

Effectiveness

Does Beet work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 15 uses evaluated
2 Possibly effective 1 Leans ineffective 12 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Oral beet may improve athletic performance associated with aerobic activities. However, it is not clear who is most likely to benefit, for which type of competition it is most useful, or what dose or duration of use is most appropriate.

Possibly Effective Exercise-induced muscle soreness
Rating & evidence shown verbatim from Natural Medicines

Drinking beetroot juice 7-8 times over 48 hours after strenuous exercise may reduce exercise-induced muscle soreness, but evidence is conflicting. <b>Details</b>: Some clinical research shows drinking beetroot juice (Love Beets Beetroot Juice, Gs Fresh Ltd.) 125 mL or 250 mL seven times over 48 hours after strenuous box jumps improves muscle soreness when compared with placebo and sodium nitrite. Other small clinical studies show that drinking beetroot juice 50-250 mL as eight separate doses over 48 hours after strenuous exerciseimproves muscle soreness and reduces tissue edema when compared with placebo.

Sources Ref 96964 Ref 97722 Ref 94461 Ref 113424
Possibly Ineffective Chronic obstructive pulmonary disease (COPD)
Rating & evidence shown verbatim from Natural Medicines

Drinking beetroot juice for up to 14 days may not improve exercise capacity in patients with COPD.

Also studied for 12 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if drinking beetroot juice is beneficial for cognitive function.

Insufficient Reliable Evidence To Rate Coronary heart disease (CHD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beetroot extract is beneficial in patients with CHD.

Insufficient Reliable Evidence To Rate Dyslipidemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beetroot is beneficial in patients with dyslipidemia.

Insufficient Reliable Evidence To Rate Exercise-induced muscle damage
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beetroot juice improves recovery from muscle damage after exercise.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Oral beet may slightly reduce blood pressure in healthy individuals, but it is unclear if it is beneficial in patients with hypertension.

Insufficient Reliable Evidence To Rate Hypertriglyceridemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beet is beneficial in patients with hypertriglyceridemia.

Insufficient Reliable Evidence To Rate Liver disease
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral beet for liver disease, there is insufficient reliable information about the clinical effects of beet for this purpose.

Insufficient Reliable Evidence To Rate Muscle strength
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beetroot juice is beneficial for muscle strength.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beet leaf or beetroot juice is beneficial for weight loss.

Insufficient Reliable Evidence To Rate Pregnancy-induced hypertension
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beetroot juice is beneficial in patients with pregnancy-induced hypertension.

Insufficient Reliable Evidence To Rate Pulmonary hypertension
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beetroot juice is beneficial in patients with pulmonary hypertension.

Insufficient Reliable Evidence To Rate Raynaud syndrome
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral beetroot juice is beneficial in patients with Raynaud syndrome.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Beet is a common food and is generally considered safe for most people when eaten or taken in normal amounts. Concentrated supplements have less long-term safety data.

People with a history of kidney stones may want to be careful, because beets contain oxalates, which can contribute to certain types of stones. People with low blood pressure should be aware that beets may lower it further.

For pregnancy and breastfeeding, beet eaten as a normal food is generally fine. However, there is not enough information on the safety of concentrated beet supplements during these times, so it is best to use caution and check with your doctor or pharmacist first.

Side effects

Beet is usually well tolerated. The most common harmless effect is beeturia — red or pink urine and sometimes red stools after eating beets. This is not dangerous, though it can be alarming if you are not expecting it.

Some people notice mild stomach upset or gas. Because beets can lower blood pressure, large amounts may cause lightheadedness in some people. People prone to kidney stones may want to limit high-oxalate foods like beets.

Beet: Reported Adverse Effects

Documented safety reports on Beet from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, beet seems to be well tolerated when used for medicinal purposes, short term.

Most Common Adverse Effects:

Orally: Red stools and red urine.

Serious Adverse Effects (Rare):

Orally: Hypocalcemia and kidney damage when ingested in large amounts.

Reports by condition
Anemia Gastrointestinal

Orally, beet juice may cause red stools. This red coloring of the stools is not harmful. Additionally, beet supplementation has been reported to cause black stools. In one case, a 79-year-old male on apixaban and clopidogrel presented with black stools, nausea, and vomiting after taking beet pills 2-3 days prior. The likelihood of upper gastrointestinal bleed was determined to be low based on factors such as normal vital signs and lack of severe anemia. The patient was diagnosed with beet-induced pseudo-hematochezia which was successfully treated with fluids and discontinuation of the beet supplement.

Other less common gastrointestinal side effects include loose stools, constipation, and nausea.

  1. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26.
  2. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36.
  3. Garnacho-Casta&ntilde;o MV, Palau-Salv&agrave; G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49.
  4. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460.
  5. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094.
  6. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178.
  7. Henrohn D, Bj&ouml;rkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
Hypocalcemia Endocrine

Theoretically, ingestion of large quantities of beets could lead to hypocalcemia because of the oxaluric acid content.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized dose of beet for supplement use. Studies have used a range of amounts of beetroot juice or powder, often based on nitrate content, but the best dose is not firmly established.

If you choose a beet supplement, follow the directions on the product label and do not exceed the recommended amount. Because product strength and nitrate content vary widely between brands, it is a good idea to check with your pharmacist or doctor, especially if you take blood pressure medicine.

Pregnancy & Breastfeeding

Beet & Breastfeeding

Insufficient reliable information

There is insufficient reliable information available about the safety of beets used medicinally during pregnancy and breast-feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 14 references that drive our Beet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Casta&ntilde;o MV, Palau-Salv&agrave; G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Bj&ouml;rkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Beet

1,177 brands in our database make a supplement containing Beet.

Product directory

Supplement products with Beet

7,974 products in our database contain Beet. Open any to see its full ingredient list and every drug interaction we check.

"10" Vegetable Multi-Plex by Puritan's Pride Capsule 90 Vegecap(s) View ingredients & interactions #3 - GB-LIV by Nutri-West Herbals Tablet Or Pill 100 Tablet(s) View ingredients & interactions #Shatter SX-7 Icy Pink Lemonade by MuscleTech Powder 10.27 oz. · 291 Gram(s) View ingredients & interactions #Shatter SX-7 Icy Pink Lemonade by MuscleTech Powder 6.12 oz. · 174 Gram(s) View ingredients & interactions +E Boost Vita-E 268 mg by Shaklee Tablet Or Pill 90 Tablet(s) View ingredients & interactions +Heart Blood Pressure by Shaklee Tablet Or Pill 60 Tablet(s) View ingredients & interactions +I Boost Iron plus C Complex by Shaklee Tablet Or Pill 90 Tablet(s) View ingredients & interactions +PlusShake Raw Chocolate by Greens+ Powder 1.5 lb · 677 Gram(s) View ingredients & interactions +PlusShake Raw Vanilla by Greens+ Powder 1.5 lb · 661 Gram(s) View ingredients & interactions 100% Casein Protein Peach-Mascarpone Cream by Body Attack Sports Nutrition Powder 1800 Gram(s) View ingredients & interactions 100% Casein Protein Peach-Mascarpone Cream by Body Attack Sports Nutrition Powder 900 Gram(s) View ingredients & interactions 100% Casein Protein Strawberry Banana Cream by Body Attack Sports Nutrition Powder 900 Gram(s) View ingredients & interactions 100% Casein Protein Strawberry Cream by Body Attack Sports Nutrition Powder 900 Gram(s) View ingredients & interactions 100% Fermented Organic Greens Organic Chocolate by Natural Factors Whole Earth & Sea Powder 7.7 Ounce(s) · 219 Gram(s) View ingredients & interactions 100% Fermented Organic Greens Unflavored by Natural Factors Whole Earth & Sea Powder 6.9 Ounce(s) · 195 Gram(s) View ingredients & interactions 100% Micellar Casein Wild Strawberry by NutraBio Powder 5 lbs · 2268 Gram(s) View ingredients & interactions 100% Micellar Casein Wild Strawberry by NutraBio Powder 2 lbs · 907 Gram(s) View ingredients & interactions 100% Natural Whey Protein Isolate Natural Mixed Berry by Bluebonnet Powder 1.1 oz. · 33 Gram(s) View ingredients & interactions 100% Natural Whey Protein Isolate Natural Mixed Berry by Bluebonnet Powder 1 lb · 462 Gram(s) View ingredients & interactions 100% Natural Whey Protein Isolate Natural Mixed Berry by Bluebonnet Powder 2 lb · 924 Gram(s) View ingredients & interactions 100% Natural Whey Protein Isolate Natural Strawberry by Bluebonnet Powder 1 lb · 462 Gram(s) View ingredients & interactions 100% Natural Whey Protein Isolate Natural Strawberry by Bluebonnet Powder 2 lb · 924 Gram(s) View ingredients & interactions 100% Natural Whey Protein Isolate Natural Strawberry by Bluebonnet Powder 1.1 oz. · 33 Gram(s) View ingredients & interactions 100% Plant-Based Protein Nutritional Shake Very Berry by Purely Inspired Powder 1.5 lbs · 680 Gram(s) View ingredients & interactions
Pharmacist Counseling Corner

Beet: Common Questions

What is Beet used for, and does it work?
People use Beet for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Beet for Athletic performance and Exercise-induced muscle soreness. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Beet interact with prescription medications?
Yes. We list 861 medications with a known interaction with Beet. Use the checker above to see how Beet interacts with a specific drug.
How are Beet interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Beet with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Beet interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Does Beetroot juice really lower blood pressure?
Some studies show Beetroot juice can cause a small, short-term drop in blood pressure thanks to its nitrate content. The effect is usually modest and varies from person to person, so it should not replace prescribed medication.
Why is my urine pink or red after eating Beets?
This is a harmless and fairly common effect called Beeturia, caused by the natural pigments in Beets. It is not dangerous and usually goes away within a day or two.
Can Beet improve my workouts?
Beetroot juice may slightly improve endurance or stamina in some people, especially recreational exercisers. The benefit is small and may be less noticeable in well-trained athletes.
Is it safe to take Beet supplements during pregnancy?
Eating Beets as a normal food is generally considered fine, but there is not enough safety information on concentrated Beet supplements during pregnancy. It is best to use caution and check with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Beet

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