Herb & supplement monograph

Black Seed Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Black Seed interacts with medications. The heart of this page is the interaction list — every drug Black Seed is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Black Seed is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Black Seed against your medication

Add one medication
Black Seed
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
On this page

Black Seed Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Black Seed drug interaction appears low for most people. None of the listed interactions are rated major, and nearly all rest on animal or lab findings rather than confirmed effects in people.

Interactions deserving the most attention

The best-documented concerns involve diabetes medications and blood pressure medications, since human studies show black seed can modestly lower blood sugar and blood pressure, which could add to these drugs' effects. People taking blood thinners such as warfarin or clopidogrel should also be aware, because animal and lab research suggests black seed may slow clotting and raise bleeding risk, even though this has not been confirmed in humans. There is also a single case report linking black seed to serotonin syndrome after surgery, so those on serotonergic drugs may want extra awareness.

What the rest of the list means

Black seed appears alongside a large number of medications, but that does not mean every combination is harmful. Most of these entries are theoretical, based on possible effects on an enzyme the body uses to clear certain medications or on findings from animal and lab studies. Many of these predicted effects have never been shown to cause meaningful changes in people.

Check your medications against Black Seed

Based on HelloPharmacist’s Black Seed interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Black Seed

912 medications have a known interaction with Black Seed, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
6-mercaptopurinePurinethol
Moderate Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.

Read the full Black Seed + 6-mercaptopurine interaction 6-mercaptopurine drug page: uses, dosage & side effects
AbciximabReoPro
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Black Seed + Abciximab interaction
AbrocitinibCibinqo
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Black Seed + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Black Seed + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcebutololRhotral, Sectral
Moderate Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Read the full Black Seed + Acebutolol interaction Acebutolol drug page: uses, dosage & side effects
AcenocoumarolSintrom
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Black Seed + Acenocoumarol interaction
AcepromazineAtravet
Moderate Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full Black Seed + Acepromazine interaction
Acetaminophen, AspirinGemnisyn
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Black Seed + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Anticoagulant/antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full Black Seed + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full Black Seed + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Moderate Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full Black Seed + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Moderate Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full Black Seed + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full Black Seed + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full Black Seed + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full Black Seed + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Read the full Black Seed + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.

Read the full Black Seed + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
Moderate Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Read the full Black Seed + Acetaminophen, Chlorpheniramine, Pseudoephedrine interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Black Seed combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Black Seed affects

Every type of medication (drug category) Black Seed is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 14 drug categories Black Seed interacts with
Anticoagulant/antiplatelet DrugsAntidiabetes DrugsAntihypertensive DrugsClopidogrel (plavix)Cns DepressantsCyclosporine (neoral, Sandimmune)Cytochrome P450 2c9 (cyp2c9) SubstratesDiuretic DrugsImmunosuppressantsPhenytoin (dilantin)Serotonergic DrugsSildenafil (viagra)Warfarin (coumadin)Prednisolone
Anticoagulant/Antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Prednisolone

Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.

Likelihood Possible Evidence D
Monograph

Black Seed: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no firmly proven benefits. It is generally well tolerated in food amounts, but supplement-strength doses are less studied, so talk to your pharmacist or doctor before using it—especially if you are pregnant, breastfeeding, or take other medicines.

Black Seed
Scientific name
Nigella sativa
Family
Ranunculaceae
Part used
Seeds and the oil pressed from the seeds
Common forms
Whole seeds, ground powder, capsules, softgels, and cold-pressed oil
People commonly use it for
  • Respiratory support (asthma, allergies, cough)
  • Digestive upset
  • Immune support
  • Blood sugar and cholesterol support
  • General inflammation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Likely safe in food amounts, but higher supplement doses are less studied long-term.

PregnancyLikely Unsafe

When used orally in amounts exceeding those found in food. Black seed may decrease or inhibit uterine contractions and may have contraceptive activity...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Black seed comes from the plant Nigella sativa, a small flowering plant in the buttercup family. It grows in parts of Eastern Europe, the Middle East, North Africa, and South and Western Asia. The tiny black seeds have been used as a spice and a traditional home remedy for hundreds of years.

People take black seed as whole seeds, as a ground powder, in capsules, or as a cold-pressed oil. Whole seeds also contain fiber and protein, while the oil is a more concentrated source of the plant's active compounds. It is popularly marketed for the respiratory system, digestion, and immune health.

How it works

The main active compound in black seed is thought to be thymoquinone, found in the seed oil. Black seed also contains other plant compounds, fatty acids, and antioxidants.

In laboratory and animal studies, these compounds appear to have antioxidant, anti-inflammatory, and antimicrobial effects, and may affect blood sugar, blood pressure, and the immune system. It is important to remember that effects seen in a test tube or in animals do not always carry over to people taking a supplement.

Effectiveness

Does Black Seed work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 54 uses evaluated
9 Possibly effective 45 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Acne
Rating & evidence shown verbatim from Natural Medicines

Topical black seed extract hydrogel seems to improve acne.

Possibly Effective Allergic rhinitis (hay fever)
Rating & evidence shown verbatim from Natural Medicines

Oral black seed oil seems to reduce symptoms of allergic rhinitis over 4-8 weeks. It is unclear if black seed is beneficial long-term.

Possibly Effective Asthma
Rating & evidence shown verbatim from Natural Medicines

Oral black seed seems to be beneficial for symptoms like wheezing and coughing and might improve lung function measures in patients with poor pulmonary function.

Possibly Effective Chronic obstructive pulmonary disease (COPD)
Rating & evidence shown verbatim from Natural Medicines

Oral black seed seems to improve lung function measures in patients with COPD using inhaled corticosteroids.

Possibly Effective Diabetes
Rating & evidence shown verbatim from Natural Medicines

Oral black seed powder in doses of at least 2 grams daily or black seed oil 1 gram daily seem to improve glucose control in patients with type 2 diabetes.

Possibly Effective Helicobacter pylori
Rating & evidence shown verbatim from Natural Medicines

Oral black seed 2 grams daily seems to improve H. pylori eradication when used in combination with standard therapies.

Possibly Effective Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Oral black seed seems to modestly improve serum lipids in patients with or without hyperlipidemia.

Possibly Effective Hypertension
Rating & evidence shown verbatim from Natural Medicines

Oral black seed powder and black seed oil seem to reduce blood pressure by a small amount. However, if it is unclear if taking black seed is beneficial in patients with hypertension.

Possibly Effective Mastalgia
Rating & evidence shown verbatim from Natural Medicines

Topical black seed oil seems to reduce breast pain.

Also studied for 45 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Anthracycline cardiotoxicity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed oil reduces cardiac toxicity associated with doxorubicin treatment.

Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral or topical black seed oil is beneficial for reducing symptoms of atopic dermatitis.

Insufficient Reliable Evidence To Rate Autoimmune thyroiditis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with autoimmune thyroiditis.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black seed for cancer, there is insufficient reliable information about the clinical effects of black seed for this condition.

Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with coronary artery disease.

Insufficient Reliable Evidence To Rate Chemotherapy-induced lymphocytopenia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for preventing febrile neutropenia.

Insufficient Reliable Evidence To Rate Chemotherapy-induced phlebitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for reducing the severity of phlebitis in patients receiving intravenous chemotherapy.

Insufficient Reliable Evidence To Rate Chronic kidney disease (CKD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed oil is beneficial for patients with CKD.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

Oral black seed might improve some measures of memory or cognitive function.

Insufficient Reliable Evidence To Rate Constipation
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black seed for constipation, there is insufficient reliable information about the clinical effects of black seed for this condition.

Insufficient Reliable Evidence To Rate Contraception
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black seed for contraception, there is insufficient reliable information about the clinical effects of black seed for this purpose.

Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with COVID-19.

Insufficient Reliable Evidence To Rate Diarrhea
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black seed for diarrhea, there is insufficient reliable information about the clinical effects of black seed for this condition.

Insufficient Reliable Evidence To Rate Dysmenorrhea
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed oil reduces menstrual pain.

Insufficient Reliable Evidence To Rate Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Oral black seed oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Epilepsy
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with epilepsy.

Insufficient Reliable Evidence To Rate Gingivitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed is beneficial for patients with gingivitis.

Insufficient Reliable Evidence To Rate Hemorrhoids
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black seed for hemorrhoids, there is insufficient reliable information about the clinical effects of black seed for this condition.

Insufficient Reliable Evidence To Rate Hepatitis C
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with hepatitis C.

Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black seed for HIV/AIDS, there is insufficient reliable information about the clinical effects of black seed for this condition.

Insufficient Reliable Evidence To Rate Impaired glucose tolerance (prediabetes)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed oil is beneficial for patients with prediabetes.

Insufficient Reliable Evidence To Rate Influenza
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral black seed for influenza, there is insufficient reliable information about the clinical effects of black seed for this condition.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed oil is beneficial for patients with insomnia.

Insufficient Reliable Evidence To Rate Lichen planus
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed oil is beneficial for patients with oral lichen planus.

Insufficient Reliable Evidence To Rate Male infertility
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed oil is beneficial for male infertility.

Insufficient Reliable Evidence To Rate Meniere disease
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with Meniere disease.

Insufficient Reliable Evidence To Rate Menopausal symptoms
Rating & evidence shown verbatim from Natural Medicines

Oral black seed has only been evaluated in combination with other ingredients; its effect when used alone is unclear. It is unclear if topical black seed oil is beneficial for menopausal symptoms.

Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with metabolic syndrome.

Insufficient Reliable Evidence To Rate Methotrexate toxicity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed oil is beneficial for reducing toxicity associated with methotrexate treatment.

Insufficient Reliable Evidence To Rate Nonalcoholic fatty liver disease (NAFLD)
Rating & evidence shown verbatim from Natural Medicines

Research suggests that oral black seed or black seed oil modestly improves some metabolic and liver health parameters in patients with NAFLD. However, some studies are small, and research related to measures of steatosis, including liver biopsy and magnetic resonance imaging (MRI), is needed.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for increasing weight loss.

Insufficient Reliable Evidence To Rate Opioid withdrawal
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for reducing symptoms of opioid withdrawal.

Insufficient Reliable Evidence To Rate Oral submucous fibrosis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for oral submucous fibrosis.

Insufficient Reliable Evidence To Rate Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed oil is beneficial for knee osteoarthritis.

Insufficient Reliable Evidence To Rate Polycystic ovary syndrome (PCOS)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for PCOS.

Insufficient Reliable Evidence To Rate Psoriasis
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical black seed for psoriasis, there is insufficient reliable information about the clinical effects of black seed for this condition.

Insufficient Reliable Evidence To Rate Radiation dermatitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed is beneficial for preventing dermatitis caused by radiotherapy.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed is beneficial for RA.

Insufficient Reliable Evidence To Rate Senile rhinitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed is beneficial for patients with senile rhinitis.

Insufficient Reliable Evidence To Rate Stress
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with stress.

Insufficient Reliable Evidence To Rate Tonsillopharyngitis
Rating & evidence shown verbatim from Natural Medicines

Oral black seed has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Ulcerative colitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral black seed is beneficial for patients with ulcerative colitis.

Insufficient Reliable Evidence To Rate Urinary incontinence
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed oil is beneficial for patients with urinary incontinence.

Insufficient Reliable Evidence To Rate Vaginal candidiasis
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using intravaginal black seed for vaginal fungal infections, there is insufficient reliable information about the clinical effects of black seed for this condition.

Insufficient Reliable Evidence To Rate Vitiligo
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical black seed oil is beneficial for patients with vitiligo.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Black seed used as a spice in food is generally considered safe for most people. Larger amounts taken as a supplement are less well studied, especially over long periods.

People with low blood pressure, low blood sugar, diabetes, or bleeding disorders should be cautious, since black seed may lower blood sugar and blood pressure or affect bleeding. If you are scheduled for surgery, it is reasonable to stop using it ahead of time and tell your care team.

Pregnancy: Avoid supplement-strength black seed during pregnancy, as larger amounts have traditionally been linked to concerns about the uterus and pregnancy. Breastfeeding: There is not enough reliable safety information, so it is best to avoid supplement doses. Always check with your pharmacist or doctor first.

Side effects

Black seed is usually well tolerated in small amounts. Possible side effects can include stomach upset, nausea, bloating, or constipation, especially at higher doses.

Applied to the skin, the oil may sometimes cause an allergic skin reaction (contact dermatitis). Rarely, allergic reactions can occur. Stop using it and seek medical care if you have swelling, trouble breathing, or a severe rash. Because it may lower blood sugar and blood pressure, watch for symptoms like dizziness or feeling faint.

Black Seed: Reported Adverse Effects

Documented safety reports on Black Seed from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally and topically, black seed seems to be well tolerated.

Most Common Adverse Effects:

Orally: Constipation, gastric burning or discomfort, nausea, and vomiting.

Reports by condition
Bleeding Genitourinary

Orally, relatively severe menstrual bleeding has occurred in one clinical trial.

  1. Safi S, Razmpoosh E, Fallahzadeh H, et al. The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial. Complement Ther Me
Constipation Gastrointestinal

In a clinical trial, unspecified gastrointestinal complaints occurred in 20% of patients taking black seed oil orally. Gastrointestinal complaints occurred rarely in another clinical trial; however, one patient in this study was hospitalized for nausea and vomiting thought to be associated with black seed oil. Gastrointestinal adverse effects to black seed have included constipation, burning sensation, epigastric discomfort, vomiting, or mild nausea. Gastrointestinal adverse effects to a specific black seed oil formulation containing 5% thymoquinone (BlaQmax) have included mild cases of bloating, burping and mild diarrhea.

  1. Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother.Res. 2003;17(10):1209-1214.
  2. Koshak AE, Koshak EA, Mobeireek AF, et al. Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial. Complement Ther Med 2021;61:102769.
  3. Akhondian, J., Parsa, A., and Rakhshande, H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13(12):CR555-CR559.
  4. Mohtashami R, Huseini HF, Heydari M, et al. Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol 2015;175:147-52.
  5. Bamosa AO, Kaatabi H, Lebdaa FM, et al. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 2010;54:344-54.
  6. Shawki M, El Wakeel L, Shatla R, et al. The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study. Epileptic Disord 2013;15:295-301.
  7. Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled
  8. Sahebkar A, Soranna D, Liu X, et al. A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens 2016;34:2127-35.
  9. Mahdavi R, Namazi N, Alizadeh M, Farajnia S. Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial. Food Funct. 2015;6(6):2041-8.
  10. Fallah Huseini H, Amini M, Mohtashami R, et al. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2013;27(12):1849-53.
  11. Thomas JV, Mohan ME, Prabhakaran P, Das S S, Maliakel B, I M K. A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study. Toxicol
Dermatitis Dermatologic

Orally, black seed can cause itching, but this adverse effect is rare. It has also been reported to cause bullous drug eruption and maculopapular eruption. Topically, black seed and its oil have been reported to cause allergic contact dermatitis. Rarely, topical use of the oil has been reported to cause a rash related to drug reaction with eosinophilia and systemic symptoms (DRESS).

  1. Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled
  2. Bonhomme A, Poreaux C, Jouen F, et al. Bullous drug eruption to Nigella sativa oil: Consideration of the use of a herbal medicine - clinical report and review of the literature. J Eur Acad Dermatol Venereol 2017;31:e217-e219.
  3. Dehavay F, Kolivras A, Scheers C. Local and systemic adverse skin reactions following the use of herbal products believed to contain Nigella sativa seeds and oil. Contact Dermatitis. 2019 Mar;80(3):176-177.
  4. Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
  5. al Sheikh, O. A. and Gad el-Rab, M. O. Allergic contact dermatitis: clinical features and profile of sensitizing allergens in Riyadh, Saudi Arabia. Int J Dermatol. 1996;35(7):493-497.
  6. Steinmann, A., Schatzle, M., Agathos, M., and Breit, R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis 1997;36(5):268-269.
  7. Fargeas M, Calugareanu A, Ben-Said B. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after topical use of Nigella sativa (black cumin) oil. Contact Dermatitis 2022;87(2):203-204.
Dermatitis Immunologic

Orally, black seed has been reported to cause bullous drug eruption and maculopapular eruption. Topically, black seed and its oil can cause allergic contact dermatitis. One case of bullous drug eruption with skin detachment has been reported for a 54-year-old woman who used black seed oil orally. The eruptions resolved following treatment with clobetasol propionate 0.05%. Although this patient showed a positive skin prick test for undiluted black seed oil, the tests were negative when the oil was diluted to 10% and 1%. A 28-year-old woman developed a rash following topical use of black seed oil. She was diagnosed with drug reaction with eosinophilia and systemic symptoms (DRESS), including enlarged lymph nodes, and required systemic corticosteroid treatment. This diagnosis was confirmed six months later following confirmation with a patch test. In another case report, a 58-year-old woman developed eczematous lesions on the lower and upper eyelids after topical application of an oil containing black seed. This reaction was followed by the development of a diffuse maculopapular eruption after taking two oral capsules containing black seed oil. It is theorized that the topical application of black seed oil led to systemic sensitization prior to the use of oral black seed in this patient.

  1. Bonhomme A, Poreaux C, Jouen F, et al. Bullous drug eruption to Nigella sativa oil: Consideration of the use of a herbal medicine - clinical report and review of the literature. J Eur Acad Dermatol Venereol 2017;31:e217-e219.
  2. Dehavay F, Kolivras A, Scheers C. Local and systemic adverse skin reactions following the use of herbal products believed to contain Nigella sativa seeds and oil. Contact Dermatitis. 2019 Mar;80(3):176-177.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
  5. al Sheikh, O. A. and Gad el-Rab, M. O. Allergic contact dermatitis: clinical features and profile of sensitizing allergens in Riyadh, Saudi Arabia. Int J Dermatol. 1996;35(7):493-497.
  6. Steinmann, A., Schatzle, M., Agathos, M., and Breit, R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis 1997;36(5):268-269.
  7. Assier H, Kouby F, Ingen-Housz-Oro S, Roux C. Severe allergic contact connubial dermatitis to Nigella Sativa Seed Oil due to repeated contacts to beard cosmetics. Contact Dermatitis 2022.
  8. Fargeas M, Calugareanu A, Ben-Said B. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after topical use of Nigella sativa (black cumin) oil. Contact Dermatitis 2022;87(2):203-204.
Diabetes Renal

Orally, black seed might cause renal dysfunction. A case of acute renal failure thought to be related to use of black seed tablets 2-2.5 grams daily has been reported for a 62 year-old patient with diabetes. Additionally, a case of acute kidney injury, rhabdomyolysis, and hepatotoxicity has been reported in an otherwise healthy 26-year-old male after taking black seed oil 1000 mg twice daily for 1 month. The patient was hospitalized for critical care management, including hemodialysis. . After 52 days in the hospital, the patient had recovered and was discharged.

  1. Arslan E, Sayin S, Demirbas S, et al. A case study report of acute renal failure associated with Nigella sativa in a diabetic patient. J Integr Med 2013;11:64-6.
  2. Sener K, Cakir A, Yesiloglu O, Altug E, Guven R, Korkut S. Rhabdomyolysis and acute kidney injury after consumption of black seed oil. Toxicon 2024;245:107787.
Muscle breakdown Hepatic

While intake of black seed has been associated with hepatotoxicity in some animal research, other animal research has not confirmed this finding. One case report describes hepatotoxicity, kidney injury, and rhabdomyolysis occurring in an otherwise healthy 26-year-old male after taking black seed oil 1000 mg twice daily for 1 month. The patient was hospitalized for critical care management, including hemodialysis. After 52 days in the hospital, the patient had recovered and was discharged.

  1. Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31:283-9.
  2. Muneera KE, Majeed A, Naveed AK. Comparative evaluation of nigella sativa (Kalonji) and simvastatin for the treatment of hyperlipidemia and in the induction of hepatotoxicity. Pak J Pharm Sci. 2015 Mar;28(2):493-8.
  3. Sener K, Cakir A, Yesiloglu O, Altug E, Guven R, Korkut S. Rhabdomyolysis and acute kidney injury after consumption of black seed oil. Toxicon 2024;245:107787.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official, standardized dose for black seed. Studies have used a wide range of amounts of seed powder or oil, and products vary a lot in strength.

The safest approach is to follow the directions on the product label and start with the lowest suggested amount. Because doses and product quality differ, check with your pharmacist or doctor before starting, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Black Seed & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 60 references that drive our Black Seed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52:23-6.
  3. Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39:59-62.
  4. Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31:283-9. PubMed
  5. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 2008;22:447-52.
  6. Zaoui, A., Cherrah, Y., Lacaille-Dubois, M. A., Settaf, A., Amarouch, H., and Hassar, M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000;55(3):379-382.
  7. Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., and Okuyama, T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol.Pharm.Bull 2001;24(3):307-310. PubMed
  8. Meral, I., Yener, Z., Kahraman, T., and Mert, N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet.Med A Physiol Pathol.Clin Med 2001;48(1
  9. Al Jishi, S. A. and Abuo, Hozaifa B. Effect of Nigella sativa on blood hemostatic function in rats. J Ethnopharmacol. 2003;85(1):7-14. PubMed
  10. Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
  11. Al Naggar, T. B., Gomez-Serranillos, M. P., Carretero, M. E., and Villar, A. M. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88(1):63-68. PubMed
  12. Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother.Res. 2003;17(10):1209-1214.
  13. Islam, S. N., Begum, P., Ahsan, T., Huque, S., and Ahsan, M. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother.Res. 2004;18(5):395-398.
  14. Fararh, K. M., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H., and Takewaki, T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet.Sci 2004;77(2):123-129. PubMed
  15. Awad, E. M. and Binder, B. R. In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa. Phytomedicine 2005;12(3):194-202. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Black Seed

136 brands in our database make a supplement containing Black Seed.

Product directory

Supplement products with Black Seed

432 products in our database contain Black Seed. Open any to see its full ingredient list and every drug interaction we check.

All-Omega by North American Herb & Spice Kid-e-Kare Liquid 2 Fluid Ounce(s) · 60 Milliliter(s) View ingredients & interactions Aller-Response by Source Naturals Tablet Or Pill 180 Tablet(s) View ingredients & interactions Ashwagandha 3600 mg by Garden of Herbz Capsule 60 Capsule(s) View ingredients & interactions Biodynamic Organic Hemp Oil Concentrate with Black Seed Oil by Dr. Mercola Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Biofilm Phase-2 Advanced by Priority One Nutritional Supplements Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Black Cumin by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Black Cumin by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Black Cumin by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Black Cumin by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Black Cumin by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Black Cumin by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Black Cumin Alcohol Free by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Black Cumin Alcohol Free by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Black Cumin Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Black Cumin Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Black Cumin SAP by NFH Softgel Capsule 60 Softgel(s) View ingredients & interactions Black Cumin Seed by NusaPure Capsule 180 Veg Cap(s) View ingredients & interactions Black Cumin Seed by Maxi Health Capsule 90 Liquid Capsule(s) View ingredients & interactions Black Cumin Seed 400 mg Full Spectrum by Swanson Capsule 60 Capsule(s) View ingredients & interactions Black Cumin Seed Oil by Health Ranger's Liquid 4 Ounce(s) · 118 mL View ingredients & interactions Black Cumin Seed Oil by Life Extension Softgel Capsule 60 Softgel(s) View ingredients & interactions Black Cumin Seed Oil by Life Extension Softgel Capsule 60 Softgel(s) View ingredients & interactions Black Cumin Seed Oil 1000 mg by Herbadiet Capsule 50 V-Cap(s) View ingredients & interactions Black Cumin Seed Oil 1000 mg by NOW Softgel Capsule 60 Softgel(s) View ingredients & interactions
Pharmacist Counseling Corner

Black Seed: Common Questions

What is Black Seed used for, and does it work?
People use Black Seed for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Black Seed for Acne, Allergic rhinitis (hay fever), Asthma and Chronic obstructive pulmonary disease (COPD). For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Black Seed interact with prescription medications?
Yes. We list 912 medications with a known interaction with Black Seed. Use the checker above to see how Black Seed interacts with a specific drug.
How are Black Seed interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Black Seed with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Black Seed interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Black Seed used for?
People use it for breathing problems like asthma and allergies, for digestion, for immune support, and to help with blood sugar, blood pressure, and cholesterol. Evidence is limited or mixed, so it is not a proven treatment for any of these.
Is Black Seed oil the same as the whole seeds?
The oil is a concentrated source of the seed's active compounds, while whole seeds also provide fiber and protein. Both are used as supplements, but the oil delivers more of compounds like thymoquinone.
Is Black Seed safe to take every day?
Using it as a food spice is generally safe, but daily use of supplement-strength doses has not been well studied long-term. Talk to your pharmacist or doctor before taking it regularly.
Can I take Black Seed while pregnant or breastfeeding?
It is best to avoid supplement amounts during pregnancy and breastfeeding because there is not enough safety information, and larger amounts have raised concerns in pregnancy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Black Seed

A rotating sample of real supplements in our database that list Black Seed — open any to see its full ingredients and every drug interaction we check.

See all 432 products with Black Seed →
Where next
Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about Black Seed?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist